ENZYME entry: EC 6.3.1.13

PURL: https://purl.expasy.org/enzyme/EC/6.3.1.13

Accepted Name

L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

Alternative Name(s)

MshC ligase

mycothiol ligase

Reaction catalysed

1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + L-cysteine + ATP = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)

Comment(s)

This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes.
Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics.
The enzyme may represent a novel target for new classes of antituberculars.
Formerly EC 6.1.1.n1.

Cross-references

BRENDA

6.3.1.13

EC2PDB

6.3.1.13

ExplorEnz

6.3.1.13

KEGG Ligand Database for Enzyme Nomenclature

6.3.1.13

IUBMB Enzyme Nomenclature

6.3.1.13

MEDLINE

Find literature relating to 6.3.1.13

MetaCyc

6.3.1.13

Rhea expert-curated reactions

6.3.1.13

UniProtKB/Swiss-Prot

Q4JXD7, MSHC1_CORJK	B1VEQ2, MSHC1_CORU7	Q4JVN7, MSHC2_CORJK
B1VDU4, MSHC2_CORU7	A0LU34, MSHC_ACIC1	C6WIA0, MSHC_ACTMD
A0JWX8, MSHC_ARTS2	C5BVB1, MSHC_BEUC1	C7MCZ4, MSHC_BRAFD
C7Q9B2, MSHC_CATAD	D5UFA8, MSHC_CELFN	A5CRN7, MSHC_CLAM3
B0RC50, MSHC_CLASE	C3PG89, MSHC_CORA7	Q6NH81, MSHC_CORDI
Q8FTD0, MSHC_COREF	A4QEA0, MSHC_CORGB	Q8NQC4, MSHC_CORGL
C4LIL9, MSHC_CORK4	Q9FB57, MSHC_CORST	Q0RLV2, MSHC_FRAAA
Q2J9N8, MSHC_FRACC	D2S6C9, MSHC_GEOOG	D0LDR0, MSHC_GORB4
C7R3Z4, MSHC_JONDD	A6W933, MSHC_KINRD	B2GIP6, MSHC_KOCRD
D2PPT3, MSHC_KRIFD	C7NHQ9, MSHC_KYTSD	C5CBT9, MSHC_MICLC
A0QF76, MSHC_MYCA1	B1MPE6, MSHC_MYCA9	P67018, MSHC_MYCBO
A1KKH3, MSHC_MYCBP	C1AQ46, MSHC_MYCBT	A4TB85, MSHC_MYCGI
B8ZRD9, MSHC_MYCLB	Q49784, MSHC_MYCLE	B2HFY1, MSHC_MYCMM
Q73YS9, MSHC_MYCPA	A0QZY0, MSHC_MYCS2	A3Q1B7, MSHC_MYCSJ
A1UHV1, MSHC_MYCSK	Q1B774, MSHC_MYCSS	A5U4F6, MSHC_MYCTA
A5WPA3, MSHC_MYCTF	C6DPT0, MSHC_MYCTK	P9WJM8, MSHC_MYCTO
P9WJM9, MSHC_MYCTU	A0PQV5, MSHC_MYCUA	A1TAS3, MSHC_MYCVP
C8X8S1, MSHC_NAKMY	D7B412, MSHC_NOCDD	Q5YVL0, MSHC_NOCFA
A1SJZ6, MSHC_NOCSJ	A1R6P9, MSHC_PAEAT	A8LH67, MSHC_PARS2
B8H8K8, MSHC_PSECP	A9WSI9, MSHC_RENSM	C0ZZW9, MSHC_RHOE4
Q0SIC6, MSHC_RHOJR	C1ASS8, MSHC_RHOOB	D2NT85, MSHC_ROTMD
A4FBV6, MSHC_SACEN	C7MWX8, MSHC_SACVD	A8M264, MSHC_SALAI
A4X6W9, MSHC_SALTO	D1BHU9, MSHC_SANKS	D6ZFG9, MSHC_SEGRD
D3Q598, MSHC_STANL	Q828M2, MSHC_STRAW	D7BSS4, MSHC_STRBB
Q9ADA4, MSHC_STRCO	B1W2Y7, MSHC_STRGG	D2AU10, MSHC_STRRD
C9Z2Z3, MSHC_STRSW	D6Y1N8, MSHC_THEBD	D1A2Q5, MSHC_THECD
Q47NV4, MSHC_THEFY	D5UPJ5, MSHC_TSUPD	D1BS17, MSHC_XYLCX

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