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ENZYME

ENZYME entry: EC 6.3.1.13

PURL: https://purl.expasy.org/enzyme/EC/6.3.1.13
Accepted Name
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Alternative Name(s)
MshC ligase
mycothiol ligase
Reaction catalysed
1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + L-cysteine + ATP = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)
Comment(s)
  • This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes.
  • Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics.
  • The enzyme may represent a novel target for new classes of antituberculars.
  • Formerly EC 6.1.1.n1.
Cross-references
BRENDA6.3.1.13
EC2PDB6.3.1.13
ExplorEnz6.3.1.13
KEGG Ligand Database for Enzyme Nomenclature6.3.1.13
IUBMB Enzyme Nomenclature6.3.1.13
MEDLINEFind literature relating to 6.3.1.13
MetaCyc6.3.1.13
Rhea expert-curated reactions6.3.1.13
UniProtKB/Swiss-Prot
Q4JXD7, MSHC1_CORJKB1VEQ2, MSHC1_CORU7Q4JVN7, MSHC2_CORJK
B1VDU4, MSHC2_CORU7A0LU34, MSHC_ACIC1C6WIA0, MSHC_ACTMD
A0JWX8, MSHC_ARTS2C5BVB1, MSHC_BEUC1C7MCZ4, MSHC_BRAFD
C7Q9B2, MSHC_CATADD5UFA8, MSHC_CELFNA5CRN7, MSHC_CLAM3
B0RC50, MSHC_CLASEC3PG89, MSHC_CORA7Q6NH81, MSHC_CORDI
Q8FTD0, MSHC_COREFA4QEA0, MSHC_CORGBQ8NQC4, MSHC_CORGL
C4LIL9, MSHC_CORK4Q9FB57, MSHC_CORSTQ0RLV2, MSHC_FRAAA
Q2J9N8, MSHC_FRACCD2S6C9, MSHC_GEOOGD0LDR0, MSHC_GORB4
C7R3Z4, MSHC_JONDDA6W933, MSHC_KINRDB2GIP6, MSHC_KOCRD
D2PPT3, MSHC_KRIFDC7NHQ9, MSHC_KYTSDC5CBT9, MSHC_MICLC
A0QF76, MSHC_MYCA1B1MPE6, MSHC_MYCA9P67018, MSHC_MYCBO
A1KKH3, MSHC_MYCBPC1AQ46, MSHC_MYCBTA4TB85, MSHC_MYCGI
B8ZRD9, MSHC_MYCLBQ49784, MSHC_MYCLEB2HFY1, MSHC_MYCMM
Q73YS9, MSHC_MYCPAA0QZY0, MSHC_MYCS2A3Q1B7, MSHC_MYCSJ
A1UHV1, MSHC_MYCSKQ1B774, MSHC_MYCSSA5U4F6, MSHC_MYCTA
A5WPA3, MSHC_MYCTFC6DPT0, MSHC_MYCTKP9WJM8, MSHC_MYCTO
P9WJM9, MSHC_MYCTUA0PQV5, MSHC_MYCUAA1TAS3, MSHC_MYCVP
C8X8S1, MSHC_NAKMYD7B412, MSHC_NOCDDQ5YVL0, MSHC_NOCFA
A1SJZ6, MSHC_NOCSJA1R6P9, MSHC_PAEATA8LH67, MSHC_PARS2
B8H8K8, MSHC_PSECPA9WSI9, MSHC_RENSMC0ZZW9, MSHC_RHOE4
Q0SIC6, MSHC_RHOJRC1ASS8, MSHC_RHOOBD2NT85, MSHC_ROTMD
A4FBV6, MSHC_SACENC7MWX8, MSHC_SACVDA8M264, MSHC_SALAI
A4X6W9, MSHC_SALTOD1BHU9, MSHC_SANKSD6ZFG9, MSHC_SEGRD
D3Q598, MSHC_STANLQ828M2, MSHC_STRAWD7BSS4, MSHC_STRBB
Q9ADA4, MSHC_STRCOB1W2Y7, MSHC_STRGGD2AU10, MSHC_STRRD
C9Z2Z3, MSHC_STRSWD6Y1N8, MSHC_THEBDD1A2Q5, MSHC_THECD
Q47NV4, MSHC_THEFYD5UPJ5, MSHC_TSUPDD1BS17, MSHC_XYLCX

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-