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ENZYME entry: EC 6.3.1.19

Accepted Name
prokaryotic ubiquitin-like protein ligase.
Alternative Name(s)
proteasome accessory factor A.
Pup-conjugating enzyme.
Pup ligase.
Pup--protein ligase.
Reaction catalysed
ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine <=> ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine
Comment(s)
  • The enzyme has been characterized from the bacteria Mycobacterium tuberculosis and Corynebacterium glutamicum.
  • It catalyzes the ligation of the prokaryotic ubiquitin-like protein (Pup) to a target protein by forming a bond between an epsilon-amino group of a lysine residue of the target protein and the gamma- carboxylate of the C-terminal glutamate of the ubiquitin-like protein (Pup).
  • The attachment of Pup, also known as Pupylation, marks proteins for proteasomal degradation.
  • Formerly EC 6.3.2.n2.
Cross-references
BRENDA6.3.1.19
EC2PDB6.3.1.19
ExplorEnz6.3.1.19
PRIAM enzyme-specific profiles6.3.1.19
KEGG Ligand Database for Enzyme Nomenclature6.3.1.19
IUBMB Enzyme Nomenclature6.3.1.19
IntEnz6.3.1.19
MEDLINEFind literature relating to 6.3.1.19
MetaCyc6.3.1.19
Rhea expert-curated reactions6.3.1.19
UniProtKB/Swiss-Prot
P72263, PAFA1_RHOER;  P72270, PAFA2_RHOER;  A0LU53, PAFA_ACIC1;  
C7LYP9, PAFA_ACIFD;  C6WIE4, PAFA_ACTMD;  A0JWY8, PAFA_ARTS2;  
B8DTX8, PAFA_BIFA0;  A1A0U7, PAFA_BIFAA;  C6AHX4, PAFA_BIFAS;  
D2Q9D0, PAFA_BIFDB;  C6A7B6, PAFA_BIFLB;  B3DRN8, PAFA_BIFLD;  
Q8G3G3, PAFA_BIFLO;  B7GUN9, PAFA_BIFLS;  C7MCY7, PAFA_BRAFD;  
C7PVV4, PAFA_CATAD;  C3PGA3, PAFA_CORA7;  Q6NH95, PAFA_CORDI;  
Q8FTE6, PAFA_COREF;  A4QE80, PAFA_CORGB;  Q8NQE1, PAFA_CORGL;  
Q4JVP8, PAFA_CORJK;  C4LIK9, PAFA_CORK4;  B1VDV5, PAFA_CORU7;  
Q0RLT2, PAFA_FRAAA;  Q2J9R8, PAFA_FRACC;  A8LH49, PAFA_FRASN;  
D2S6E4, PAFA_GEOOG;  D0LDT3, PAFA_GORB4;  C7R405, PAFA_JONDD;  
A6W972, PAFA_KINRD;  B2GIN9, PAFA_KOCRD;  D2Q3K3, PAFA_KRIFD;  
C5CBV0, PAFA_MICLC;  A0QFB7, PAFA_MYCA1;  B1MAJ3, PAFA_MYCA9;  
P64944, PAFA_MYCBO;  A1KKE3, PAFA_MYCBP;  C1AQ16, PAFA_MYCBT;  
A4TB47, PAFA_MYCGI;  B8ZRF5, PAFA_MYCLB;  P54077, PAFA_MYCLE;  
B2HFV4, PAFA_MYCMM;  Q73YX0, PAFA_MYCPA;  A0QZ42, PAFA_MYCS2;  
A3PZG1, PAFA_MYCSJ;  A1UFV1, PAFA_MYCSK;  Q1B959, PAFA_MYCSS;  
A5U4C3, PAFA_MYCTA;  A5WP74, PAFA_MYCTF;  C6DPW7, PAFA_MYCTK;  
P9WNU6, PAFA_MYCTO;  P9WNU7, PAFA_MYCTU;  A0PQT1, PAFA_MYCUA;  
A1TAP0, PAFA_MYCVP;  C8XAP5, PAFA_NAKMY;  Q5YUX4, PAFA_NOCFA;  
A1SK16, PAFA_NOCSJ;  A1R6Q9, PAFA_PAEAT;  B8H8L8, PAFA_PSECP;  
A9WSH9, PAFA_RENSM;  C0ZZU4, PAFA_RHOE4;  Q0SIG2, PAFA_RHOJR;  
C1ASP4, PAFA_RHOOB;  D2NT93, PAFA_ROTMD;  A4FBY4, PAFA_SACEN;  
C7MWV3, PAFA_SACVD;  A8M2A6, PAFA_SALAI;  A4X747, PAFA_SALTO;  
D1BHT7, PAFA_SANKS;  Q828I4, PAFA_STRAW;  Q9RJ61, PAFA_STRCO;  
B1W310, PAFA_STRGG;  D2ATU8, PAFA_STRRD;  C9Z4D4, PAFA_STRSW;  
D1A2T1, PAFA_THECD;  Q47NZ6, PAFA_THEFY;  D1BS28, PAFA_XYLCX;  

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