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ENZYME entry: EC 6.3.1.20

Accepted Name
lipoate--protein ligase.
Alternative Name(s)
lipoate protein ligase.
lipoate-protein ligase A.
LPL.
Reaction catalysed
(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)
Comment(s)
  • This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid.
  • The enzyme attaches lipoic acid to the lipoyl domains of certain key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein).
  • Lipoylation is essential for the function of these enzymes.
  • The enzyme can also use octanoate instead of lipoate.
  • Formerly EC 2.7.7.63.
Cross-references
BRENDA6.3.1.20
EC2PDB6.3.1.20
ExplorEnz6.3.1.20
PRIAM enzyme-specific profiles6.3.1.20
KEGG Ligand Database for Enzyme Nomenclature6.3.1.20
IUBMB Enzyme Nomenclature6.3.1.20
IntEnz6.3.1.20
MEDLINEFind literature relating to 6.3.1.20
MetaCyc6.3.1.20
Rhea expert-curated reactions6.3.1.20
UniProtKB/Swiss-Prot
Q8IEG9, LIPLA_PLAF7;  A0A0H3JR16, LPLA1_STAAM;  A0A0H3JX98, LPLA2_STAAM;  
P0DN72, LPLA2_STRPG;  Q9HKT2, LPLAC_THEAC;  Q9HKT1, LPLAN_THEAC;  
A0KMH0, LPLA_AERHH;  Q9Y9E6, LPLA_AERPE;  A4SQ09, LPLA_AERS4;  
P60809, LPLA_BDEBA;  Q7VR65, LPLA_BLOFL;  Q492U9, LPLA_BLOPB;  
A8ALX2, LPLA_CITK8;  A7MIG6, LPLA_CROS8;  A7ZVS8, LPLA_ECO24;  
B7UR14, LPLA_ECO27;  B7MNJ3, LPLA_ECO45;  B7LEN2, LPLA_ECO55;  
P60776, LPLA_ECO57;  B7NW66, LPLA_ECO7I;  B7MTD2, LPLA_ECO81;  
B7LXU8, LPLA_ECO8A;  C4ZT68, LPLA_ECOBW;  B1XFJ6, LPLA_ECODH;  
A8A8B4, LPLA_ECOHS;  A1AJV3, LPLA_ECOK1;  Q0T8S7, LPLA_ECOL5;  
Q8FA49, LPLA_ECOL6;  B1IS33, LPLA_ECOLC;  P32099, LPLA_ECOLI;  
B7NH54, LPLA_ECOLU;  B6I6N3, LPLA_ECOSE;  B1LEJ1, LPLA_ECOSM;  
Q1R257, LPLA_ECOUT;  A4W6A2, LPLA_ENT38;  B7LNS6, LPLA_ESCF3;  
B5Y273, LPLA_KLEP3;  A6TI00, LPLA_KLEP7;  P47512, LPLA_MYCGE;  
P75394, LPLA_MYCPN;  C6DKP5, LPLA_PECCP;  Q1QEC2, LPLA_PSYCK;  
B5F534, LPLA_SALA4;  A9MRA3, LPLA_SALAR;  Q57G36, LPLA_SALCH;  
B5FTD0, LPLA_SALDC;  B5R2K1, LPLA_SALEP;  B5R9V4, LPLA_SALG2;  
B4TH09, LPLA_SALHS;  B4T4I0, LPLA_SALNS;  Q5PK29, LPLA_SALPA;  
A9N7E6, LPLA_SALPB;  C0Q7M8, LPLA_SALPC;  B5BAK2, LPLA_SALPK;  
B4TU46, LPLA_SALSV;  Q8Z0U0, LPLA_SALTI;  Q8ZJV1, LPLA_SALTY;  
O13629, LPLA_SCHPO;  A8GDS3, LPLA_SERP5;  B2TZR8, LPLA_SHIB3;  
Q31SV2, LPLA_SHIBS;  Q327K9, LPLA_SHIDS;  Q3YU08, LPLA_SHISS;  
A5F8E4, LPLA_VIBC3;  Q9KS71, LPLA_VIBCH;  C3LM83, LPLA_VIBCM;  
B3LQ66, LPLA_YEAS1;  B5VLD2, LPLA_YEAS6;  A6ZPT1, LPLA_YEAS7;  
P47051, LPLA_YEAST;  A1JPK8, LPLA_YERE8;  A7FHI0, LPLA_YERP3;  
Q1C748, LPLA_YERPA;  B2K5K7, LPLA_YERPB;  Q8ZDY2, LPLA_YERPE;  
A9R087, LPLA_YERPG;  Q1CII3, LPLA_YERPN;  A4TIN0, LPLA_YERPP;  
Q66A10, LPLA_YERPS;  B1JJ36, LPLA_YERPY;  O07608, LPLJ_BACSU;  

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