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ENZYME entry: EC 6.3.1.20

Accepted Name
lipoate--protein ligase.
Alternative Name(s)
lipoate protein ligase.
lipoate-protein ligase A.
LPL.
Reaction catalysed
(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)
Comment(s)
  • This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid.
  • The enzyme attaches lipoic acid to the lipoyl domains of certain key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein).
  • Lipoylation is essential for the function of these enzymes.
  • The enzyme can also use octanoate instead of lipoate.
  • Formerly EC 2.7.7.63.
Cross-references
BRENDA6.3.1.20
EC2PDB6.3.1.20
ExplorEnz6.3.1.20
PRIAM enzyme-specific profiles6.3.1.20
KEGG Ligand Database for Enzyme Nomenclature6.3.1.20
IUBMB Enzyme Nomenclature6.3.1.20
IntEnz6.3.1.20
MEDLINEFind literature relating to 6.3.1.20
MetaCyc6.3.1.20
Rhea expert-curated reactions6.3.1.20
UniProtKB/Swiss-Prot
A0A0H3JR16, LPLA1_STAAM;  A0A0H3JX98, LPLA2_STAAM;  P0DN72, LPLA2_STRPG;  
Q9HKT2, LPLAC_THEAC;  Q9HKT1, LPLAN_THEAC;  A0KMH0, LPLA_AERHH;  
Q9Y9E6, LPLA_AERPE;  A4SQ09, LPLA_AERS4;  P60809, LPLA_BDEBA;  
Q7VR65, LPLA_BLOFL;  Q492U9, LPLA_BLOPB;  A8ALX2, LPLA_CITK8;  
A7MIG6, LPLA_CROS8;  A7ZVS8, LPLA_ECO24;  B7UR14, LPLA_ECO27;  
B7MNJ3, LPLA_ECO45;  B7LEN2, LPLA_ECO55;  P60776, LPLA_ECO57;  
B7NW66, LPLA_ECO7I;  B7MTD2, LPLA_ECO81;  B7LXU8, LPLA_ECO8A;  
C4ZT68, LPLA_ECOBW;  B1XFJ6, LPLA_ECODH;  A8A8B4, LPLA_ECOHS;  
A1AJV3, LPLA_ECOK1;  Q0T8S7, LPLA_ECOL5;  Q8FA49, LPLA_ECOL6;  
B1IS33, LPLA_ECOLC;  P32099, LPLA_ECOLI;  B7NH54, LPLA_ECOLU;  
B6I6N3, LPLA_ECOSE;  B1LEJ1, LPLA_ECOSM;  Q1R257, LPLA_ECOUT;  
A4W6A2, LPLA_ENT38;  B7LNS6, LPLA_ESCF3;  B5Y273, LPLA_KLEP3;  
A6TI00, LPLA_KLEP7;  P47512, LPLA_MYCGE;  P75394, LPLA_MYCPN;  
C6DKP5, LPLA_PECCP;  Q1QEC2, LPLA_PSYCK;  B5F534, LPLA_SALA4;  
A9MRA3, LPLA_SALAR;  Q57G36, LPLA_SALCH;  B5FTD0, LPLA_SALDC;  
B5R2K1, LPLA_SALEP;  B5R9V4, LPLA_SALG2;  B4TH09, LPLA_SALHS;  
B4T4I0, LPLA_SALNS;  Q5PK29, LPLA_SALPA;  A9N7E6, LPLA_SALPB;  
C0Q7M8, LPLA_SALPC;  B5BAK2, LPLA_SALPK;  B4TU46, LPLA_SALSV;  
Q8Z0U0, LPLA_SALTI;  Q8ZJV1, LPLA_SALTY;  O13629, LPLA_SCHPO;  
A8GDS3, LPLA_SERP5;  B2TZR8, LPLA_SHIB3;  Q31SV2, LPLA_SHIBS;  
Q327K9, LPLA_SHIDS;  Q3YU08, LPLA_SHISS;  A5F8E4, LPLA_VIBC3;  
Q9KS71, LPLA_VIBCH;  C3LM83, LPLA_VIBCM;  B3LQ66, LPLA_YEAS1;  
B5VLD2, LPLA_YEAS6;  A6ZPT1, LPLA_YEAS7;  P47051, LPLA_YEAST;  
A1JPK8, LPLA_YERE8;  A7FHI0, LPLA_YERP3;  Q1C748, LPLA_YERPA;  
B2K5K7, LPLA_YERPB;  Q8ZDY2, LPLA_YERPE;  A9R087, LPLA_YERPG;  
Q1CII3, LPLA_YERPN;  A4TIN0, LPLA_YERPP;  Q66A10, LPLA_YERPS;  
B1JJ36, LPLA_YERPY;  O07608, LPLJ_BACSU;  

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