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ENZYME

ENZYME entry: EC 6.3.1.20

Accepted Name
lipoate--protein ligase
Alternative Name(s)
lipoate protein ligase
lipoate-protein ligase A
LPL
Reaction catalysed
(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)
Comment(s)
  • This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid.
  • The enzyme attaches lipoic acid to the lipoyl domains of certain key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein).
  • Lipoylation is essential for the function of these enzymes.
  • The enzyme can also use octanoate instead of lipoate.
  • Formerly EC 2.7.7.63.
Cross-references
BRENDA6.3.1.20
EC2PDB6.3.1.20
ExplorEnz6.3.1.20
PRIAM enzyme-specific profiles6.3.1.20
KEGG Ligand Database for Enzyme Nomenclature6.3.1.20
IUBMB Enzyme Nomenclature6.3.1.20
IntEnz6.3.1.20
MEDLINEFind literature relating to 6.3.1.20
MetaCyc6.3.1.20
Rhea expert-curated reactions6.3.1.20
UniProtKB/Swiss-Prot
Q8IEG9, LIPLA_PLAF7A0A0H3JR16, LPLA1_STAAMA0A0H3JX98, LPLA2_STAAM
P0DN72, LPLA2_STRPGQ9HKT2, LPLAC_THEACQ9HKT1, LPLAN_THEAC
A0KMH0, LPLA_AERHHQ9Y9E6, LPLA_AERPEA4SQ09, LPLA_AERS4
P60809, LPLA_BDEBAQ7VR65, LPLA_BLOFLQ492U9, LPLA_BLOPB
A8ALX2, LPLA_CITK8A7MIG6, LPLA_CROS8A7ZVS8, LPLA_ECO24
B7UR14, LPLA_ECO27B7MNJ3, LPLA_ECO45B7LEN2, LPLA_ECO55
P60776, LPLA_ECO57B7NW66, LPLA_ECO7IB7MTD2, LPLA_ECO81
B7LXU8, LPLA_ECO8AC4ZT68, LPLA_ECOBWB1XFJ6, LPLA_ECODH
A8A8B4, LPLA_ECOHSA1AJV3, LPLA_ECOK1Q0T8S7, LPLA_ECOL5
Q8FA49, LPLA_ECOL6B1IS33, LPLA_ECOLCP32099, LPLA_ECOLI
B7NH54, LPLA_ECOLUB6I6N3, LPLA_ECOSEB1LEJ1, LPLA_ECOSM
Q1R257, LPLA_ECOUTA4W6A2, LPLA_ENT38B7LNS6, LPLA_ESCF3
B5Y273, LPLA_KLEP3A6TI00, LPLA_KLEP7P47512, LPLA_MYCGE
P75394, LPLA_MYCPNC6DKP5, LPLA_PECCPQ1QEC2, LPLA_PSYCK
B5F534, LPLA_SALA4A9MRA3, LPLA_SALARQ57G36, LPLA_SALCH
B5FTD0, LPLA_SALDCB5R2K1, LPLA_SALEPB5R9V4, LPLA_SALG2
B4TH09, LPLA_SALHSB4T4I0, LPLA_SALNSQ5PK29, LPLA_SALPA
A9N7E6, LPLA_SALPBC0Q7M8, LPLA_SALPCB5BAK2, LPLA_SALPK
B4TU46, LPLA_SALSVQ8Z0U0, LPLA_SALTIQ8ZJV1, LPLA_SALTY
O13629, LPLA_SCHPOA8GDS3, LPLA_SERP5B2TZR8, LPLA_SHIB3
Q31SV2, LPLA_SHIBSQ327K9, LPLA_SHIDSQ3YU08, LPLA_SHISS
A5F8E4, LPLA_VIBC3Q9KS71, LPLA_VIBCHC3LM83, LPLA_VIBCM
B3LQ66, LPLA_YEAS1B5VLD2, LPLA_YEAS6A6ZPT1, LPLA_YEAS7
P47051, LPLA_YEASTA1JPK8, LPLA_YERE8A7FHI0, LPLA_YERP3
Q1C748, LPLA_YERPAB2K5K7, LPLA_YERPBQ8ZDY2, LPLA_YERPE
A9R087, LPLA_YERPGQ1CII3, LPLA_YERPNA4TIN0, LPLA_YERPP
Q66A10, LPLA_YERPSB1JJ36, LPLA_YERPYO07608, LPLJ_BACSU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.1.-
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