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ENZYME entry: EC 6.3.1.8

Accepted Name
Glutathionylspermidine synthase.
Alternative Name(s)
Gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming).
Glutathione:spermidine ligase (ADP-forming).
Glutathionylspermidine synthetase.
GSP synthetase.
Reaction catalysed
Glutathione + spermidine + ATP <=> glutathionylspermidine + ADP + phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • Involved in the synthesis of trypanothione in trypanosomatids.
  • The enzyme from Escherichia coli is bifunctional and also catalyzes the EC 3.5.1.78 reaction, resulting in a net hydrolysis of ATP.
Cross-references
BRENDA6.3.1.8
EC2PDB6.3.1.8
ExplorEnz6.3.1.8
PRIAM enzyme-specific profiles6.3.1.8
KEGG Ligand Database for Enzyme Nomenclature6.3.1.8
IUBMB Enzyme Nomenclature6.3.1.8
IntEnz6.3.1.8
MEDLINEFind literature relating to 6.3.1.8
MetaCyc6.3.1.8
Rhea expert-curated reactions6.3.1.8
UniProtKB/Swiss-Prot
P90518, GSP_CRIFA;  P0AES0, GSP_ECOLI;  P0AES1, GSP_SHIFL;  

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