ENZYME entry: EC 6.3.1.8
Accepted Name |
Glutathionylspermidine synthase.
|
Alternative Name(s) |
Gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming). |
Glutathione:spermidine ligase (ADP-forming). |
Glutathionylspermidine synthetase. |
GSP synthetase. |
Reaction catalysed |
Glutathione + spermidine + ATP <=> glutathionylspermidine + ADP + phosphate |
Cofactor(s) |
Mg(2+).
|
Comment(s) |
- Involved in the synthesis of trypanothione in trypanosomatids.
- The enzyme from Escherichia coli is bifunctional and also catalyzes
the EC 3.5.1.78 reaction, resulting in a net hydrolysis of ATP.
|
Cross-references |
BRENDA | 6.3.1.8 |
EC2PDB | 6.3.1.8 |
ExplorEnz | 6.3.1.8 |
PRIAM enzyme-specific profiles | 6.3.1.8 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.1.8 |
IUBMB Enzyme Nomenclature | 6.3.1.8 |
IntEnz | 6.3.1.8 |
MEDLINE | Find literature relating to 6.3.1.8 |
MetaCyc | 6.3.1.8 |
Rhea expert-curated reactions | 6.3.1.8 |
UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 6.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-