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ENZYME

ENZYME entry: EC 6.3.2.11

Accepted Name
carnosine synthase
Alternative Name(s)
carnosine synthetase
Reaction catalysed
beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)
Comment(s)
  • This enzyme was thought to form AMP, but studies with highly purified enzyme proved that it forms ADP.
  • Carnosine is a dipeptide that is present at high concentrations in skeletal muscle and the olfactory bulb of vertebrates.
  • It is also found in the skeletal muscle of some invertebrates.
  • The enzyme can also catalyze the formation of homocarnosine from 4-aminobutyrate and L-histidine, with much lower activity.
Cross-references
BRENDA6.3.2.11
EC2PDB6.3.2.11
ExplorEnz6.3.2.11
KEGG Ligand Database for Enzyme Nomenclature6.3.2.11
IUBMB Enzyme Nomenclature6.3.2.11
MEDLINEFind literature relating to 6.3.2.11
MetaCyc6.3.2.11
Rhea expert-curated reactions6.3.2.11
UniProtKB/Swiss-Prot
D3KCC4, CRNS1_CHICKA5YM72, CRNS1_HUMANQ6ZPS2, CRNS1_MOUSE

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