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ENZYME entry: EC 6.3.2.11

Accepted Name
carnosine synthase.
Alternative Name(s)
carnosine synthetase.
Reaction catalysed
ATP + beta-alanine + L-histidine <=> ADP + carnosine + H(+) + phosphate
Comment(s)
  • This enzyme was thought to form AMP, but studies with highly purified enzyme proved that it forms ADP.
  • Carnosine is a dipeptide that is present at high concentrations in skeletal muscle and the olfactory bulb of vertebrates.
  • It is also found in the skeletal muscle of some invertebrates.
  • The enzyme can also catalyze the formation of homocarnosine from 4-aminobutyrate and L-histidine, with much lower activity.
Cross-references
BRENDA6.3.2.11
EC2PDB6.3.2.11
ExplorEnz6.3.2.11
PRIAM enzyme-specific profiles6.3.2.11
KEGG Ligand Database for Enzyme Nomenclature6.3.2.11
IUBMB Enzyme Nomenclature6.3.2.11
IntEnz6.3.2.11
MEDLINEFind literature relating to 6.3.2.11
MetaCyc6.3.2.11
Rhea expert-curated reactions6.3.2.11
UniProtKB/Swiss-Prot
D3KCC4, CRNS1_CHICK;  A5YM72, CRNS1_HUMAN;  Q6ZPS2, CRNS1_MOUSE;  

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