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ENZYME

ENZYME entry: EC 6.3.2.2

Accepted Name
glutamate--cysteine ligase
Alternative Name(s)
gamma-glutamylcysteine synthetase
gamma-glutamyl-L-cysteine synthetase
Reaction catalysed
ATP + L-cysteine + L-glutamate <=> ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate
Comment(s)
Can use L-aminohexanoate in place of glutamate.
Cross-references
BRENDA6.3.2.2
EC2PDB6.3.2.2
ExplorEnz6.3.2.2
PRIAM enzyme-specific profiles6.3.2.2
KEGG Ligand Database for Enzyme Nomenclature6.3.2.2
IUBMB Enzyme Nomenclature6.3.2.2
IntEnz6.3.2.2
MEDLINEFind literature relating to 6.3.2.2
MetaCyc6.3.2.2
Rhea expert-curated reactions6.3.2.2
UniProtKB/Swiss-Prot
A0R5N1, EGTA_MYCS2P9WPK6, EGTA_MYCTOP9WPK7, EGTA_MYCTU
A0JZ00, GCS21_ARTS2Q8FMD3, GCS21_COREFQ0RRF4, GCS21_FRAAA
Q2JF65, GCS21_FRACCQ5X7D7, GCS21_LEGPAA5IAK4, GCS21_LEGPC
Q5WYT4, GCS21_LEGPLA0QQQ2, GCS21_MYCS2A3PTZ8, GCS21_MYCSJ
A1UAE3, GCS21_MYCSKA1T324, GCS21_MYCVPQ5YW64, GCS21_NOCFA
A1SKY7, GCS21_NOCSJA1R1K8, GCS21_PAEATQ0SH75, GCS21_RHOJR
Q1B017, GCS21_RUBXDA4FDR2, GCS21_SACENQ82PX1, GCS21_STRAW
A0K1R7, GCS22_ARTS2Q8FT06, GCS22_COREFQ0RKL9, GCS22_FRAAA
Q2J8X3, GCS22_FRACCQ5X1G7, GCS22_LEGPAA5IGU3, GCS22_LEGPC
Q5WT78, GCS22_LEGPLA0QXJ6, GCS22_MYCS2A3Q5U2, GCS22_MYCSJ
A1ULE3, GCS22_MYCSKA1TEV2, GCS22_MYCVPQ5YNU2, GCS22_NOCFA
A1SLX8, GCS22_NOCSJA1R8M8, GCS22_PAEATQ0SEQ7, GCS22_RHOJR
Q1AWY5, GCS22_RUBXDA4FHB5, GCS22_SACENQ82PC4, GCS22_STRAW
Q0RHA0, GCS23_FRAAAA0R3T8, GCS23_MYCS2A1SN17, GCS23_NOCSJ
A1RAU1, GCS23_PAEATQ0S8V5, GCS23_RHOJRQ1AWB5, GCS23_RUBXD
Q0RZ64, GCS24_RHOJRB9MBR0, GCS2_ACIETA1W2Y5, GCS2_ACISJ
A8I5N7, GCS2_AZOC5A1K7T8, GCS2_AZOSBQ6MKW4, GCS2_BDEBA
Q2L0C4, GCS2_BORA1Q7WQP1, GCS2_BORBRQ7W1R5, GCS2_BORPA
A9IFL0, GCS2_BORPDQ7VS51, GCS2_BORPEQ89NS0, GCS2_BRADU
A5ESE1, GCS2_BRASBA4YLK4, GCS2_BRASOB1YQ56, GCS2_BURA4
A0K2U6, GCS2_BURCHB4E558, GCS2_BURCJQ0BJQ3, GCS2_BURCM
Q39L14, GCS2_BURL3A9AJC7, GCS2_BURM1A3MQF9, GCS2_BURM7
A2S6N7, GCS2_BURM9Q62FV3, GCS2_BURMAA1V8X0, GCS2_BURMS
B1K1H9, GCS2_BURO0Q1BZN8, GCS2_BURO1A3NPL5, GCS2_BURP0
Q3JXS3, GCS2_BURP1A3N3Y5, GCS2_BURP6Q63Z36, GCS2_BURPS
Q2T2K3, GCS2_BURTAA4J9Z8, GCS2_BURVGA9WAH5, GCS2_CHLAA
B8GCV1, GCS2_CHLADB9LEN6, GCS2_CHLSYQ7NTZ9, GCS2_CHRVO
A8AJN1, GCS2_CITK8A5CQQ7, GCS2_CLAM3B0REM7, GCS2_CLASE
Q6NF59, GCS2_CORDIA4QHD8, GCS2_CORGBQ8NM44, GCS2_CORGL
Q4JXP1, GCS2_CORJKB1VHM9, GCS2_CORU7A7MNP0, GCS2_CROS8
Q1LHL9, GCS2_CUPMCQ0K5N7, GCS2_CUPNHQ46VZ0, GCS2_CUPPJ
B3R7K5, GCS2_CUPTRQ47E74, GCS2_DECARA8LME6, GCS2_DINSH
A7ZIW5, GCS2_ECO24B7UKM3, GCS2_ECO27B7MEZ2, GCS2_ECO45
B7L8G3, GCS2_ECO55Q8XBX1, GCS2_ECO57B5YPS4, GCS2_ECO5E
B7NLU0, GCS2_ECO7IB7MRL6, GCS2_ECO81B7M4R1, GCS2_ECO8A
C4ZV25, GCS2_ECOBWA7ZXK4, GCS2_ECOHSA1A8L2, GCS2_ECOK1
Q0TK91, GCS2_ECOL5Q8FK30, GCS2_ECOL6B1IYM7, GCS2_ECOLC
P77213, GCS2_ECOLIB7N9I5, GCS2_ECOLUB6I0N0, GCS2_ECOSE
B1LKH2, GCS2_ECOSMQ1REY3, GCS2_ECOUTA4W7T6, GCS2_ENT38
B7LLN2, GCS2_ESCF3Q7NI89, GCS2_GLOVIB9LMG2, GCS2_HALLT
Q5V3Q5, GCS2_HALMAB0R5I4, GCS2_HALS3Q9HPZ9, GCS2_HALSA
D4GZN2, GCS2_HALVDQ18H65, GCS2_HALWDA9B2Z8, GCS2_HERA2
A4G807, GCS2_HERARA6T1A0, GCS2_JANMAQ28R34, GCS2_JANSC
B5Y035, GCS2_KLEP3A6T5Z2, GCS2_KLEP7C1DD64, GCS2_LARHH
Q5ZS01, GCS2_LEGPHQ6AE97, GCS2_LEIXXB1Y1M1, GCS2_LEPCP
A2SKM7, GCS2_METPPC5CC09, GCS2_MICLCA0QLR0, GCS2_MYCA1
P64694, GCS2_MYCBOA1KFQ5, GCS2_MYCBPC1AKA9, GCS2_MYCBT
Q73T00, GCS2_MYCPAQ1BEJ0, GCS2_MYCSSA5TZF9, GCS2_MYCTA
P9WPK8, GCS2_MYCTOP9WPK9, GCS2_MYCTUA0PNK6, GCS2_MYCUA
Q3IQ21, GCS2_NATPDQ2Y8S0, GCS2_NITMUA1TJA3, GCS2_PARC0
A1B2I7, GCS2_PARDPB2T7N6, GCS2_PARPJQ13SL4, GCS2_PARXL
A1VTI2, GCS2_POLNAQ123D5, GCS2_POLSJA6V5Z4, GCS2_PSEA7
B7V9S6, GCS2_PSEA8Q02LX5, GCS2_PSEABQ9I1T4, GCS2_PSEAE
Q1I926, GCS2_PSEE4Q4K7H5, GCS2_PSEF5A4XUP3, GCS2_PSEMY
Q88HV0, GCS2_PSEPKQ8XU95, GCS2_RALN1B2UG86, GCS2_RALPJ
Q7USI0, GCS2_RHOBAQ2RRI3, GCS2_RHORTA7NK74, GCS2_ROSCS
A5UWI8, GCS2_ROSS1Q5LRC0, GCS2_RUEPOB5EYH4, GCS2_SALA4
A8M5J6, GCS2_SALAIA9ML47, GCS2_SALARQ57RZ1, GCS2_SALCH
B5FMI4, GCS2_SALDCB5QUY5, GCS2_SALEPB5R705, GCS2_SALG2
B4TAD4, GCS2_SALHSB4SXT5, GCS2_SALNSQ5PMF1, GCS2_SALPA
A9MVD3, GCS2_SALPBC0PVN0, GCS2_SALPCB5BCW8, GCS2_SALPK
B4TP54, GCS2_SALSVQ8Z8M0, GCS2_SALTIA4X7Y6, GCS2_SALTO
Q8ZR41, GCS2_SALTYQ324W2, GCS2_SHIBSQ32J06, GCS2_SHIDS
Q0T746, GCS2_SHIF8Q83M14, GCS2_SHIFLQ3Z4L2, GCS2_SHISS
Q01ZM2, GCS2_SOLUEA9GS95, GCS2_SORC5Q9KY07, GCS2_STRCO
Q47LS4, GCS2_THEFYQ3M5M3, GCS2_TRIV2A1WFG0, GCS2_VEREI
Q8GU95, GSH1A_ORYSIQ688Q9, GSH1A_ORYSJA2YL07, GSH1B_ORYSI
Q6Z3A3, GSH1B_ORYSJQ0VSY7, GSH1_ALCBSQ5E7F8, GSH1_ALIF1
B5FAD9, GSH1_ALIFMB6EGB3, GSH1_ALISLP46309, GSH1_ARATH
C1DJH1, GSH1_AZOVDQ1LTQ6, GSH1_BAUCHQ7WES2, GSH1_BORBR
Q7W3F2, GSH1_BORPAA9HYE0, GSH1_BORPDO23736, GSH1_BRAJU
B8D9I8, GSH1_BUCA5P57485, GSH1_BUCAIP58994, GSH1_BUCAP
B8D7U0, GSH1_BUCATQ89AD8, GSH1_BUCBPQ20117, GSH1_CAEEL
Q9HF78, GSH1_CANAXA8ANP6, GSH1_CITK8Q97IV1, GSH1_CLOAB
A7MJ27, GSH1_CROS8Q54PC2, GSH1_DICDIQ9W3K5, GSH1_DROME
A7ZQC1, GSH1_ECO24B7UHB1, GSH1_ECO27B7MKG2, GSH1_ECO45
B7LEA4, GSH1_ECO55Q8X900, GSH1_ECO57B5Z2A3, GSH1_ECO5E
B7NSH3, GSH1_ECO7IB7MYJ3, GSH1_ECO81B7M9D0, GSH1_ECO8A
C4ZYT8, GSH1_ECOBWB1XCM1, GSH1_ECODHA8A3H0, GSH1_ECOHS
Q0TEI7, GSH1_ECOL5P0A6X0, GSH1_ECOL6B1IUY6, GSH1_ECOLC
P0A6W9, GSH1_ECOLIB7N6S3, GSH1_ECOLUB6I679, GSH1_ECOSE
B1LPG3, GSH1_ECOSMQ1R808, GSH1_ECOUTC5BGG7, GSH1_EDWI9
A4WDQ2, GSH1_ENT38B2VHD0, GSH1_ERWT9B7LVZ1, GSH1_ESCF3
Q2S8F7, GSH1_HAHCHP48506, GSH1_HUMANA6SX59, GSH1_JANMA
B5XVC3, GSH1_KLEP3A6TCV4, GSH1_KLEP7Q72RD4, GSH1_LEPIC
Q8F4D5, GSH1_LEPINQ9ZNX6, GSH1_MEDTRP97494, GSH1_MOUSE
Q8X0X0, GSH1_NEUCRQ9NFN6, GSH1_ONCVOQ6D1T4, GSH1_PECAS
C6DCQ5, GSH1_PECCPQ7N7A4, GSH1_PHOLLQ6LMV1, GSH1_PHOPR
B4EUV9, GSH1_PROMHQ48PX1, GSH1_PSE14A6VDX9, GSH1_PSEA7
B7V3V0, GSH1_PSEA8Q02EG1, GSH1_PSEABQ9HTY6, GSH1_PSEAE
Q1IGL1, GSH1_PSEE4Q4KK14, GSH1_PSEF5A4XP63, GSH1_PSEMY
Q3KJQ5, GSH1_PSEPFQ88R90, GSH1_PSEPKB1JET4, GSH1_PSEPW
Q88AR1, GSH1_PSESMP61379, GSH1_PSESYQ3IEB7, GSH1_PSET1
Q4ZZU4, GSH1_PSEU2P19468, GSH1_RATQ21EP1, GSH1_SACD2
B5F346, GSH1_SALA4A9MFZ5, GSH1_SALARQ57KV3, GSH1_SALCH
B5FSX4, GSH1_SALDCB5QV72, GSH1_SALEPB5RDE8, GSH1_SALG2
B4TF06, GSH1_SALHSB4T394, GSH1_SALNSQ5PF10, GSH1_SALPA
A9N0B5, GSH1_SALPBC0PWL7, GSH1_SALPCB5BEN1, GSH1_SALPK
B4TT00, GSH1_SALSVQ8Z4D6, GSH1_SALTIO68838, GSH1_SALTY
Q09768, GSH1_SCHPOA8GA13, GSH1_SERP5A1S4F9, GSH1_SHEAM
B0TK23, GSH1_SHEHHQ8EBF9, GSH1_SHEONA8H1U8, GSH1_SHEPA
B2U053, GSH1_SHIB3Q31X58, GSH1_SHIBSQ32CN5, GSH1_SHIDS
Q0T1B9, GSH1_SHIF8Q3YYH0, GSH1_SHISSQ2NVK9, GSH1_SODGM
O22493, GSH1_SOLLCA4VG81, GSH1_STUS1Q1W2L8, GSH1_TOBAC
A7MZY1, GSH1_VIBC1Q9KUG5, GSH1_VIBCHQ87LS2, GSH1_VIBPA
Q8DC38, GSH1_VIBVUQ7MHS5, GSH1_VIBVYQ8D2V5, GSH1_WIGBR
P32477, GSH1_YEASTA1JK14, GSH1_YERE8Q8ZBU2, GSH1_YERPE
Q66E64, GSH1_YERPSQ8XK30, GSHAB_CLOPEQ6ANW2, GSHAB_DESPS
Q82ZG8, GSHAB_ENTFAQ88UW5, GSHAB_LACPLQ926X7, GSHAB_LISIN
Q71VZ1, GSHAB_LISMFQ8Y3R3, GSHAB_LISMOA0AMA3, GSHAB_LISW6
Q65RX0, GSHAB_MANSMQ9CM00, GSHAB_PASMUQ8E399, GSHAB_STRA3
Q8DXM9, GSHAB_STRA5Q8DW15, GSHAB_STRMUQ5LYY5, GSHAB_STRT1
Q5M3J8, GSHAB_STRT2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
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