ENZYME entry: EC 6.3.2.35
| Accepted Name |
|---|
| D-alanine--D-serine ligase.
|
| Reaction catalysed |
|---|
| ATP + D-alanine + D-serine <=> ADP + D-alanyl-D-serine + H(+) + phosphate |
| Comment(s) |
|---|
- The product of this enzyme, D-alanyl-D-serine, can be incorporated
into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-
alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine--D-
alanine ligase.
- The resulting peptidoglycan does not bind the glycopeptide
antibiotics vancomycin and teicoplanin, conferring resistance on the
bacteria.
|
| Cross-references |
|---|
| BRENDA | 6.3.2.35 |
| EC2PDB | 6.3.2.35 |
| ExplorEnz | 6.3.2.35 |
| PRIAM enzyme-specific profiles | 6.3.2.35 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.35 |
| IUBMB Enzyme Nomenclature | 6.3.2.35 |
| IntEnz | 6.3.2.35 |
| MEDLINE | Find literature relating to 6.3.2.35 |
| MetaCyc | 6.3.2.35 |
| Rhea expert-curated reactions | 6.3.2.35 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-