ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 6.3.2.35

Accepted Name
D-alanine--D-serine ligase.
Reaction catalysed
D-alanine + D-serine + ATP <=> D-alanyl-D-serine + ADP + phosphate
Comment(s)
The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D- alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine--D- alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
Cross-references
BRENDA	6.3.2.35
EC2PDB	6.3.2.35
ExplorEnz	6.3.2.35
PRIAM enzyme-specific profiles	6.3.2.35
KEGG Ligand Database for Enzyme Nomenclature	6.3.2.35
IUBMB Enzyme Nomenclature	6.3.2.35
IntEnz	6.3.2.35
MEDLINE	Find literature relating to 6.3.2.35
MetaCyc	6.3.2.35

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