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ENZYME

ENZYME entry: EC 6.3.2.35

PURL: https://purl.expasy.org/enzyme/EC/6.3.2.35
Accepted Name
D-alanine--D-serine ligase
Reaction catalysed
D-serine + D-alanine + ATP = D-alanyl-D-serine + ADP + phosphate + H(+)
Comment(s)
  • The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D- alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine--D- alanine ligase.
  • The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
Cross-references
BRENDA6.3.2.35
EC2PDB6.3.2.35
ExplorEnz6.3.2.35
KEGG Ligand Database for Enzyme Nomenclature6.3.2.35
IUBMB Enzyme Nomenclature6.3.2.35
MEDLINEFind literature relating to 6.3.2.35
MetaCyc6.3.2.35
Rhea expert-curated reactions6.3.2.35
UniProtKB/Swiss-Prot
P29753, VANC1_ENTGAQ47720, VANC2_ENTCA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-