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ENZYME entry: EC 6.3.2.38
Accepted Name |
N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase.
|
Alternative Name(s) |
N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine synthase. |
Reaction catalysed |
ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine |
Comment(s) |
- Requires Mg(2+).
- The enzyme is involved in the biosynthesis of aerobactin,
a dihydroxamate siderophore.
- It belongs to a class of siderophore synthases known as type A
nonribosomal peptide synthase-independent synthases (NIS).
- Type A enzymes are responsible for the formation of amide or ester
bonds between polyamines or amino alcohols and a prochiral carboxyl
group of citrate.
- The enzyme is believed to form an adenylate intermediate prior to
ligation.
- Formerly EC 6.3.2.27.
|
Cross-references |
BRENDA | 6.3.2.38 |
EC2PDB | 6.3.2.38 |
ExplorEnz | 6.3.2.38 |
PRIAM enzyme-specific profiles | 6.3.2.38 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.38 |
IUBMB Enzyme Nomenclature | 6.3.2.38 |
IntEnz | 6.3.2.38 |
MEDLINE | Find literature relating to 6.3.2.38 |
MetaCyc | 6.3.2.38 |
Rhea expert-curated reactions | 6.3.2.38 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-