ENZYME

ENZYME entry: EC 6.3.2.38

Accepted Name

N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase.

Alternative Name(s)

N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine synthase.

Reaction catalysed

2 ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine + H(2)O <=> 2 ADP + 2 phosphate + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine

Cofactor(s)

Mg(2+).

Comment(s)

Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation.
It is a dihydroxamate comprising two molecules of N(6)-acetyl-N(6)- hydroxy-L-lysine and one molecule of citrate.
This enzyme catalyzes the first of two synthase reactions to link N(6)-acetyl-N(6)-hydroxy-L-lysine and citrate.
Formerly EC 6.3.2.27.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature