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ENZYME entry: EC 6.3.2.38

Accepted Name
N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase.
Alternative Name(s)
N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine synthase.
Reaction catalysed
ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine
Comment(s)
  • Requires Mg(2+).
  • The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore.
  • It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS).
  • Type A enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate.
  • The enzyme is believed to form an adenylate intermediate prior to ligation.
  • Formerly EC 6.3.2.27.
Cross-references
BRENDA6.3.2.38
EC2PDB6.3.2.38
ExplorEnz6.3.2.38
PRIAM enzyme-specific profiles6.3.2.38
KEGG Ligand Database for Enzyme Nomenclature6.3.2.38
IUBMB Enzyme Nomenclature6.3.2.38
IntEnz6.3.2.38
MEDLINEFind literature relating to 6.3.2.38
MetaCyc6.3.2.38
Rhea expert-curated reactions6.3.2.38
UniProtKB/Swiss-Prot
Q47316, IUCA_ECOLX;  Q76BS7, IUCA_VIBMI;  

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