ENZYME entry: EC 6.3.2.45
| Accepted Name |
|---|
| UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-
diaminoheptanedioate ligase.
|
| Alternative Name(s) |
|---|
| Murein peptide ligase. |
| Reaction catalysed |
|---|
| ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate <=> ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate |
| Cofactor(s) |
|---|
| Mg(2+).
|
| Comment(s) |
|---|
- The enzyme catalyzes the reincorporation into peptidoglycan of the
tripeptide L-alanyl-gamma-D-glutamyl-2,6-meso-diaminoheptanedioate
released during the maturation and constant remodeling of this
bacterial cell wall polymer that occur during cell growth and
division.
- The enzyme can also use the tetrapeptide L-alanyl-gamma-D-glutamyl-
meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl-
gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine in
vivo and in vitro.
|
| Cross-references |
|---|
| BRENDA | 6.3.2.45 |
| EC2PDB | 6.3.2.45 |
| ExplorEnz | 6.3.2.45 |
| PRIAM enzyme-specific profiles | 6.3.2.45 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.45 |
| IUBMB Enzyme Nomenclature | 6.3.2.45 |
| IntEnz | 6.3.2.45 |
| MEDLINE | Find literature relating to 6.3.2.45 |
| MetaCyc | 6.3.2.45 |
| Rhea expert-curated reactions | 6.3.2.45 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-