ENZYME entry: EC 6.3.2.45

Accepted Name

UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate ligase.

Alternative Name(s)

Murein peptide ligase.

Reaction catalysed

ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate <=> ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate

Cofactor(s)

Mg(2+).

Comment(s)

The enzyme catalyzes the reincorporation into peptidoglycan of the tripeptide L-alanyl-gamma-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division.
The enzyme can also use the tetrapeptide L-alanyl-gamma-D-glutamyl- meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine in vivo and in vitro.

Cross-references

BRENDA

6.3.2.45

EC2PDB

6.3.2.45

ExplorEnz

6.3.2.45

PRIAM enzyme-specific profiles

6.3.2.45

KEGG Ligand Database for Enzyme Nomenclature

6.3.2.45

IUBMB Enzyme Nomenclature

6.3.2.45

IntEnz

6.3.2.45

MEDLINE

Find literature relating to 6.3.2.45

MetaCyc

6.3.2.45

UniProtKB/Swiss-Prot

P37773, MPL_ECOLI;

P43948, MPL_HAEIN;

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-