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ENZYME entry: EC 6.3.2.45

Accepted Name
UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate ligase.
Alternative Name(s)
murein peptide ligase.
Reaction catalysed
ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
Comment(s)
  • The enzyme catalyzes the reincorporation into peptidoglycan of the tripeptide L-alanyl-gamma-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division.
  • The enzyme can also use the tetrapeptide L-alanyl-gamma-D-glutamyl- meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine in vivo and in vitro.
Cross-references
BRENDA6.3.2.45
EC2PDB6.3.2.45
ExplorEnz6.3.2.45
PRIAM enzyme-specific profiles6.3.2.45
KEGG Ligand Database for Enzyme Nomenclature6.3.2.45
IUBMB Enzyme Nomenclature6.3.2.45
IntEnz6.3.2.45
MEDLINEFind literature relating to 6.3.2.45
MetaCyc6.3.2.45
Rhea expert-curated reactions6.3.2.45
UniProtKB/Swiss-Prot
P37773, MPL_ECOLI;  P43948, MPL_HAEIN;  

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