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ENZYME entry: EC

Accepted Name
tenuazonic acid synthetase
Reaction catalysed
acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid
  • This fungal enzyme, isolated from Magnaporthe oryzae, is an non- ribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) hybrid protein that consists of condensation (C), adenylation (A) and peptidyl-carrier protein (PCP) domains in the NRPS portion and a ketosynthase (KS) domain in the PKS portion.
  • ATP is required for activation of isoleucine, which is then condensed with acetoacetyl-CoA.
  • Cyclization and release from the enzyme are catalyzed by the KS domain.
PRIAM enzyme-specific profiles6.3.2.50
KEGG Ligand Database for Enzyme Nomenclature6.3.2.50
IUBMB Enzyme Nomenclature6.3.2.50
MEDLINEFind literature relating to
Rhea expert-curated reactions6.3.2.50
G4N137, TAS1_PYRO7

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