ENZYME entry: EC 6.3.2.50
| Accepted Name |
|---|
| Tenuazonic acid synthetase.
|
| Reaction catalysed |
|---|
| ATP + L-isoleucine + acetoacetyl-CoA <=> AMP + diphosphate + tenuazonic acid + CoA |
| Comment(s) |
|---|
- This fungal enzyme, isolated from Magnaporthe oryzae, is an non-
ribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) hybrid
protein that consists of condensation (C), adenylation (A) and
peptidyl-carrier protein (PCP) domains in the NRPS portion and a
ketosynthase (KS) domain in the PKS portion.
- ATP is required for activation of isoleucine, which is then condensed
with acetoacetyl-CoA.
- Cyclization and release from the enzyme are catalyzed by the KS
domain.
|
| Cross-references |
|---|
| BRENDA | 6.3.2.50 |
| EC2PDB | 6.3.2.50 |
| ExplorEnz | 6.3.2.50 |
| PRIAM enzyme-specific profiles | 6.3.2.50 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.50 |
| IUBMB Enzyme Nomenclature | 6.3.2.50 |
| IntEnz | 6.3.2.50 |
| MEDLINE | Find literature relating to 6.3.2.50 |
| MetaCyc | 6.3.2.50 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-