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ENZYME entry: EC 6.3.2.50
Accepted Name |
tenuazonic acid synthetase.
|
Reaction catalysed |
acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid |
Comment(s) |
- This fungal enzyme, isolated from Magnaporthe oryzae, is an non-
ribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) hybrid
protein that consists of condensation (C), adenylation (A) and
peptidyl-carrier protein (PCP) domains in the NRPS portion and a
ketosynthase (KS) domain in the PKS portion.
- ATP is required for activation of isoleucine, which is then condensed
with acetoacetyl-CoA.
- Cyclization and release from the enzyme are catalyzed by the KS
domain.
|
Cross-references |
BRENDA | 6.3.2.50 |
EC2PDB | 6.3.2.50 |
ExplorEnz | 6.3.2.50 |
PRIAM enzyme-specific profiles | 6.3.2.50 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.50 |
IUBMB Enzyme Nomenclature | 6.3.2.50 |
IntEnz | 6.3.2.50 |
MEDLINE | Find literature relating to 6.3.2.50 |
MetaCyc | 6.3.2.50 |
Rhea expert-curated reactions | 6.3.2.50 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-