A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 6.3.2.50

Accepted Name
Tenuazonic acid synthetase.
Reaction catalysed
ATP + L-isoleucine + acetoacetyl-CoA <=> AMP + diphosphate + tenuazonic acid + CoA
Comment(s)
  • This fungal enzyme, isolated from Magnaporthe oryzae, is an non- ribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) hybrid protein that consists of condensation (C), adenylation (A) and peptidyl-carrier protein (PCP) domains in the NRPS portion and a ketosynthase (KS) domain in the PKS portion.
  • ATP is required for activation of isoleucine, which is then condensed with acetoacetyl-CoA.
  • Cyclization and release from the enzyme are catalyzed by the KS domain.
Cross-references
BRENDA6.3.2.50
EC2PDB6.3.2.50
ExplorEnz6.3.2.50
PRIAM enzyme-specific profiles6.3.2.50
KEGG Ligand Database for Enzyme Nomenclature6.3.2.50
IUBMB Enzyme Nomenclature6.3.2.50
IntEnz6.3.2.50
MEDLINEFind literature relating to 6.3.2.50
MetaCyc6.3.2.50

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-