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ENZYME entry: EC 6.3.2.55

Accepted Name
2-((L-alanin-3-ylcarbamoyl)methyl)-3-(2-aminoethylcarbamoyl)-2- hydroxypropanoate synthase.
Reaction catalysed
ATP + 2-((2-aminoethylcarbamoyl)methyl)-2-hydroxybutanedioate + L-2,3-diaminopropanoate <=> AMP + diphosphate + 2-((L-alanin-3-ylcarbamoyl)methyl)-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate
Comment(s)
  • Requires Mg(2+).
  • The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B.
  • It belongs to a class of siderophore synthases known as type C nonribosomal peptide synthase-independent synthases (NIS).
  • Type B NIS enzymes recognize esterified or amidated derivatives of carboxylic acids.
  • The enzyme likely forms a 2-((2-aminoethylcarbamoyl)methyl)-2- hydroxybutanedioate adenylate intermediate prior to ligation.
Cross-references
BRENDA6.3.2.55
EC2PDB6.3.2.55
ExplorEnz6.3.2.55
PRIAM enzyme-specific profiles6.3.2.55
KEGG Ligand Database for Enzyme Nomenclature6.3.2.55
IUBMB Enzyme Nomenclature6.3.2.55
IntEnz6.3.2.55
MEDLINEFind literature relating to 6.3.2.55
MetaCyc6.3.2.55
Rhea expert-curated reactions6.3.2.55
UniProtKB/Swiss-Prot
Q2G1M8, SBNF_STAA8

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