ENZYME entry: EC 6.3.2.55
Accepted Name |
2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-
hydroxypropanoate synthase.
|
Reaction catalysed |
(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate |
Comment(s) |
- Requires Mg(2+).
- The enzyme, characterized from the bacterium Staphylococcus aureus,
is involved in the biosynthesis of the siderophore staphyloferrin B.
- It belongs to a class of siderophore synthases known as type
C nonribosomal peptide synthase-independent synthases (NIS).
- Type B NIS enzymes recognize esterified or amidated derivatives of
carboxylic acids.
- The enzyme likely forms a 2-[(2-aminoethylcarbamoyl)methyl]-2-
hydroxybutanedioate adenylate intermediate prior to ligation.
|
Cross-references |
BRENDA | 6.3.2.55 |
EC2PDB | 6.3.2.55 |
ExplorEnz | 6.3.2.55 |
PRIAM enzyme-specific profiles | 6.3.2.55 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.55 |
IUBMB Enzyme Nomenclature | 6.3.2.55 |
IntEnz | 6.3.2.55 |
MEDLINE | Find literature relating to 6.3.2.55 |
MetaCyc | 6.3.2.55 |
Rhea expert-curated reactions | 6.3.2.55 |
UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-