ENZYME entry: EC 6.3.2.56
Accepted Name |
staphyloferrin B synthase.
|
Reaction catalysed |
2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP <=> AMP + diphosphate + H(+) + staphyloferrin B |
Comment(s) |
- Requires Mg(2+).
- The enzyme, characterized from the bacterium Staphylococcus aureus,
catalyzes the last step in the biosynthesis of the siderophore
staphyloferrin B.
- It belongs to a class of siderophore synthases known as type B
nonribosomal peptide synthase-independent synthases (NIS).
- Type B NIS enzymes recognize the delta-acid group of 2-oxoglutarate.
- The enzyme forms a 2-oxoglutarate adenylate intermediate prior to
ligation.
|
Cross-references |
BRENDA | 6.3.2.56 |
EC2PDB | 6.3.2.56 |
ExplorEnz | 6.3.2.56 |
PRIAM enzyme-specific profiles | 6.3.2.56 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.56 |
IUBMB Enzyme Nomenclature | 6.3.2.56 |
IntEnz | 6.3.2.56 |
MEDLINE | Find literature relating to 6.3.2.56 |
MetaCyc | 6.3.2.56 |
Rhea expert-curated reactions | 6.3.2.56 |
UniProtKB/Swiss-Prot |
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