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ENZYME entry: EC 6.3.2.56

Accepted Name
staphyloferrin B synthase.
Reaction catalysed
2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP <=> AMP + diphosphate + H(+) + staphyloferrin B
Comment(s)
  • Requires Mg(2+).
  • The enzyme, characterized from the bacterium Staphylococcus aureus, catalyzes the last step in the biosynthesis of the siderophore staphyloferrin B.
  • It belongs to a class of siderophore synthases known as type B nonribosomal peptide synthase-independent synthases (NIS).
  • Type B NIS enzymes recognize the delta-acid group of 2-oxoglutarate.
  • The enzyme forms a 2-oxoglutarate adenylate intermediate prior to ligation.
Cross-references
BRENDA6.3.2.56
EC2PDB6.3.2.56
ExplorEnz6.3.2.56
PRIAM enzyme-specific profiles6.3.2.56
KEGG Ligand Database for Enzyme Nomenclature6.3.2.56
IUBMB Enzyme Nomenclature6.3.2.56
IntEnz6.3.2.56
MEDLINEFind literature relating to 6.3.2.56
MetaCyc6.3.2.56
Rhea expert-curated reactions6.3.2.56
UniProtKB/Swiss-Prot
Q2G1N1, SBNC_STAA8

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