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ENZYME

ENZYME entry: EC 6.3.2.57

PURL: https://purl.expasy.org/enzyme/EC/6.3.2.57
Accepted Name
staphyloferrin A synthase
Reaction catalysed
N(5)-[(S)-citryl]-D-ornithine + citrate + ATP = staphyloferrin A + AMP + diphosphate + H(+)
Comment(s)
  • Requires Mg(2+).
  • The enzyme, characterized from the bacterium Staphylococcus aureus, catalyzes the last step in the biosynthesis of the siderophore staphyloferrin A.
  • It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS).
  • Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate.
  • The enzyme forms a citrate adenylate intermediate prior to ligation.
Cross-references
BRENDA6.3.2.57
EC2PDB6.3.2.57
ExplorEnz6.3.2.57
KEGG Ligand Database for Enzyme Nomenclature6.3.2.57
IUBMB Enzyme Nomenclature6.3.2.57
MEDLINEFind literature relating to 6.3.2.57
MetaCyc6.3.2.57
Rhea expert-curated reactions6.3.2.57
UniProtKB/Swiss-Prot
Q2FW72, SFNAB_STAA8

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