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ENZYME entry: EC 6.3.2.57

Accepted Name
Staphyloferrin A synthase.
Reaction catalysed
ATP + 3-((2-aminopentan-5-oylcarbamoyl)methyl)-3-hydroxybutanoate + citrate <=> AMP + diphosphate + staphyloferrin A
Comment(s)
  • Requires Mg(2+).
  • The enzyme, characterized from the bacterium Staphylococcus aureus, catalyzes the last step in the biosynthesis of the siderophore staphyloferrin A.
  • It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS).
  • Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate.
  • The enzyme forms a citrate adenylate intermediate prior to ligation.
Cross-references
BRENDA6.3.2.57
EC2PDB6.3.2.57
ExplorEnz6.3.2.57
PRIAM enzyme-specific profiles6.3.2.57
KEGG Ligand Database for Enzyme Nomenclature6.3.2.57
IUBMB Enzyme Nomenclature6.3.2.57
IntEnz6.3.2.57
MEDLINEFind literature relating to 6.3.2.57
MetaCyc6.3.2.57
Rhea expert-curated reactions6.3.2.57

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
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