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ENZYME entry: EC 6.3.2.58

Accepted Name
D-ornithine--citrate ligase.
Reaction catalysed
ATP + D-ornithine + citrate <=> AMP + diphosphate + N(5)-((S)-citryl)-D-ornithine
Comment(s)
  • Requires Mg(2+).
  • The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin A.
  • It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS).
  • Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate.
  • The enzyme forms a citrate adenylate intermediate prior to ligation.
Cross-references
BRENDA6.3.2.58
EC2PDB6.3.2.58
ExplorEnz6.3.2.58
PRIAM enzyme-specific profiles6.3.2.58
KEGG Ligand Database for Enzyme Nomenclature6.3.2.58
IUBMB Enzyme Nomenclature6.3.2.58
IntEnz6.3.2.58
MEDLINEFind literature relating to 6.3.2.58
MetaCyc6.3.2.58
Rhea expert-curated reactions6.3.2.58
UniProtKB/Swiss-Prot
Q2FW70, SFNAD_STAA8

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