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ENZYME entry: EC 6.3.2.59

Accepted Name
3-methyl-D-ornithine--L-lysine ligase.
Alternative Name(s)
3-methylornithine--L-lysine ligase.
N(6)-[(2R,3R)-3-methylornithyl]-L-lysine synthase.
Reaction catalysed
(3R)-3-methyl-D-ornithine + ATP + L-lysine <=> (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate
Comment(s)
  • The enzyme participates in the biosynthesis of L-pyrrolysine, a naturally occurring, genetically coded amino acid found in some methanogenic archaea and a few bacterial species.
  • L-pyrrolysine is present in several methyltransferases that are involved in methyl transfer from methylated amine compounds to coenzyme M.
Cross-references
BRENDA6.3.2.59
EC2PDB6.3.2.59
ExplorEnz6.3.2.59
PRIAM enzyme-specific profiles6.3.2.59
KEGG Ligand Database for Enzyme Nomenclature6.3.2.59
IUBMB Enzyme Nomenclature6.3.2.59
IntEnz6.3.2.59
MEDLINEFind literature relating to 6.3.2.59
MetaCyc6.3.2.59
Rhea expert-curated reactions6.3.2.59
UniProtKB/Swiss-Prot
Q8TUC0, PYLC_METAC;  Q46E79, PYLC_METBF;  Q8PWY3, PYLC_METMA;  

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