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ENZYME

ENZYME entry: EC 6.3.2.6

Accepted Name
phosphoribosylaminoimidazolesuccinocarboxamide synthase
Alternative Name(s)
4-(N-succinocarboxamide)-5-aminoimidazole synthetase
4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase
5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase
phosphoribosylaminoimidazole-succinocarboxamide synthase
phosphoribosylaminoimidazolesuccinocarboxamide synthetase
phosphoribosylaminoimidazole-succinocarboxamide synthetase
SAICARs
SAICAR synthase
SAICAR synthetase
Reaction catalysed
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate <=> (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate
Comment(s)
Forms part of the purine biosynthesis pathway.
Cross-references
BRENDA6.3.2.6
EC2PDB6.3.2.6
ExplorEnz6.3.2.6
PRIAM enzyme-specific profiles6.3.2.6
KEGG Ligand Database for Enzyme Nomenclature6.3.2.6
IUBMB Enzyme Nomenclature6.3.2.6
IntEnz6.3.2.6
MEDLINEFind literature relating to 6.3.2.6
MetaCyc6.3.2.6
Rhea expert-curated reactions6.3.2.6
UniProtKB/Swiss-Prot
Q10457, PUR6_CAEELP38024, PUR6_CHICKQ9I7S8, PUR6_DROME
P22234, PUR6_HUMANQ9DCL9, PUR6_MOUSEQ5RB59, PUR6_PONAB
P51583, PUR6_RATQ8UEB7, PUR71_AGRFCQ89IB0, PUR71_BRADU
Q9A5F9, PUR71_CAUVCQ98NM8, PUR71_RHILOQ8UCE7, PUR72_AGRFC
Q89W81, PUR72_BRADUQ9A3G2, PUR72_CAUVCQ98I23, PUR72_RHILO
B0CD47, PUR7_ACAM1Q6F6U0, PUR7_ACIADB7GV30, PUR7_ACIB3
B7I289, PUR7_ACIB5B2I2E3, PUR7_ACIBCB0VPX5, PUR7_ACIBS
A3MA70, PUR7_ACIBTB0VA00, PUR7_ACIBYA5FVI6, PUR7_ACICJ
B7J6C1, PUR7_ACIF2B5ELM2, PUR7_ACIF5A6VN04, PUR7_ACTSZ
A4SR47, PUR7_AERS4B2UP00, PUR7_AKKM8Q222U2, PUR7_ALBFT
Q0VRH1, PUR7_ALCBSQ5E4Q3, PUR7_ALIF1B5FEP5, PUR7_ALIFM
B6EMJ7, PUR7_ALISLQ5WJ89, PUR7_ALKCKB4RZW3, PUR7_ALTMD
B7GFT5, PUR7_ANOFWO67881, PUR7_AQUAEP38025, PUR7_ARATH
O28996, PUR7_ARCFUQ5P7J7, PUR7_AROAEB6YRK7, PUR7_AZOPC
A1K9I4, PUR7_AZOSBC3PBM7, PUR7_BACAAC3L529, PUR7_BACAC
Q81ZH5, PUR7_BACANB7JM82, PUR7_BACC0Q73EN8, PUR7_BACC1
B7IUV0, PUR7_BACC2C1EV60, PUR7_BACC3B7H4T3, PUR7_BACC4
B7HS29, PUR7_BACC7A7GKH5, PUR7_BACCNB9J1K2, PUR7_BACCQ
Q81IQ6, PUR7_BACCRQ63GT6, PUR7_BACCZQ5LH03, PUR7_BACFN
Q64XV7, PUR7_BACFRQ6HPA7, PUR7_BACHKA9VRE8, PUR7_BACMK
P12046, PUR7_BACSUQ8A004, PUR7_BACTNQ6G338, PUR7_BARHE
Q6FZJ2, PUR7_BARQUA9IVH1, PUR7_BART1Q1LU15, PUR7_BAUCH
B8DTV0, PUR7_BIFA0A1A0S2, PUR7_BIFAAB3DT37, PUR7_BIFLD
Q8G5A9, PUR7_BIFLOB7GU64, PUR7_BIFLSQ7WMI1, PUR7_BORBR
Q7WB15, PUR7_BORPAA9HZF7, PUR7_BORPDQ7VY42, PUR7_BORPE
C0ZKC3, PUR7_BREBNB2S578, PUR7_BRUA1Q2YNG1, PUR7_BRUA2
A6X1J2, PUR7_BRUA4Q57DR3, PUR7_BRUABA9MAL9, PUR7_BRUC2
C0RIH6, PUR7_BRUMBQ8YGN6, PUR7_BRUMEA5VQ20, PUR7_BRUO2
B0CLG9, PUR7_BRUSIQ8G178, PUR7_BRUSUA8MCJ8, PUR7_CALMQ
Q8RC58, PUR7_CALS4A7ZD85, PUR7_CAMC1A7GYK7, PUR7_CAMC5
A0RPI2, PUR7_CAMFFA7I1M0, PUR7_CAMHCA8FKT8, PUR7_CAMJ8
A7H4M4, PUR7_CAMJDQ9PHZ9, PUR7_CAMJEA1VYM4, PUR7_CAMJJ
Q5HVQ1, PUR7_CAMJRP43060, PUR7_CANAXP27602, PUR7_CANMA
B3PC16, PUR7_CELJUA0RW02, PUR7_CENSYQ11IU8, PUR7_CHESB
A9WK38, PUR7_CHLAAB8GCM2, PUR7_CHLADQ3AQN3, PUR7_CHLCH
B3ECH5, PUR7_CHLL2Q3B3M5, PUR7_CHLL3B3QP02, PUR7_CHLP8
B3EQL0, PUR7_CHLPBA1BF89, PUR7_CHLPDA4SE69, PUR7_CHLPM
B9LC05, PUR7_CHLSYB3QYX5, PUR7_CHLT3Q8KDT4, PUR7_CHLTE
Q1QTP9, PUR7_CHRSDQ7P1P8, PUR7_CHRVOB5EGN6, PUR7_CITBB
A8ADB1, PUR7_CITK8Q97J95, PUR7_CLOABA7FXD7, PUR7_CLOB1
C3L2V3, PUR7_CLOB6A6LSA9, PUR7_CLOB8B2V3B9, PUR7_CLOBA
B2TN72, PUR7_CLOBBA5I5W3, PUR7_CLOBHC1FV80, PUR7_CLOBJ
B1IL61, PUR7_CLOBKA7GHA0, PUR7_CLOBLB1KZ59, PUR7_CLOBM
B9E4L0, PUR7_CLOK1A5N0Q4, PUR7_CLOK5A0Q1J4, PUR7_CLONN
Q0TTB4, PUR7_CLOP1Q8XMK6, PUR7_CLOPEQ0SV52, PUR7_CLOPS
Q895U7, PUR7_CLOTEQ480B3, PUR7_COLP3B5Y714, PUR7_COPPD
Q9RHX2, PUR7_CORAMQ6NFG4, PUR7_CORDIQ8FML6, PUR7_COREF
A4QGZ4, PUR7_CORGBQ8NMH6, PUR7_CORGLB1VIK2, PUR7_CORU7
Q83CA8, PUR7_COXBUA7ML04, PUR7_CROS8Q1LR36, PUR7_CUPMC
Q0KE53, PUR7_CUPNHQ475J5, PUR7_CUPPJB2AHE3, PUR7_CUPTR
B8HK56, PUR7_CYAP4P50124, PUR7_CYBJAQ11TT6, PUR7_CYTH3
Q479W2, PUR7_DECARC1CYX1, PUR7_DEIDVQ1J2B4, PUR7_DEIGD
Q9RXT0, PUR7_DEIRAC0QH22, PUR7_DESAHB8FI50, PUR7_DESAL
B8FP01, PUR7_DESHDQ24QH2, PUR7_DESHYA8ZVI6, PUR7_DESOH
Q6AK95, PUR7_DESPSA4J726, PUR7_DESRMA5EXP1, PUR7_DICNV
A8LSK4, PUR7_DINSHA7ZPS1, PUR7_ECO24B7UGM6, PUR7_ECO27
B7MHW9, PUR7_ECO45B7LCL4, PUR7_ECO55P0A7D9, PUR7_ECO57
B5Z013, PUR7_ECO5EB7NQL4, PUR7_ECO7IB7MYB5, PUR7_ECO81
B7M7H9, PUR7_ECO8AC4ZX51, PUR7_ECOBWB1XAE8, PUR7_ECODH
A8A2W8, PUR7_ECOHSQ0TF00, PUR7_ECOL5P0A7D8, PUR7_ECOL6
B1IWI3, PUR7_ECOLCP0A7D7, PUR7_ECOLIB7N658, PUR7_ECOLU
B6I546, PUR7_ECOSEB1LNC6, PUR7_ECOSMC5B7A4, PUR7_EDWI9
Q2GHH2, PUR7_EHRCRB2KCE9, PUR7_ELUMPA4WD56, PUR7_ENT38
Q833Y6, PUR7_ENTFAB2VE61, PUR7_ERWT9Q2NCK7, PUR7_ERYLH
B7LKG5, PUR7_ESCF3B1YJ02, PUR7_EXIS2C4L296, PUR7_EXISA
B0S341, PUR7_FINM2A6GYJ4, PUR7_FLAPJQ8REV1, PUR7_FUSNN
B9M5S1, PUR7_GEODFQ39X66, PUR7_GEOMGQ74BF0, PUR7_GEOSL
C6E6C1, PUR7_GEOSMA5G5H3, PUR7_GEOURQ7NJB6, PUR7_GLOVI
A9HJF3, PUR7_GLUDAQ5FNL4, PUR7_GLUOXA5UBF4, PUR7_HAEIE
A5UFF7, PUR7_HAEIGP43851, PUR7_HAEINQ2SCM9, PUR7_HAHCH
Q9KF60, PUR7_HALH5A1WVI0, PUR7_HALHLQ9HNU7, PUR7_HALSA
C4K789, PUR7_HAMD5Q7VFQ6, PUR7_HELHPA9B302, PUR7_HERA2
B0UW56, PUR7_HISS2Q0BYZ9, PUR7_HYPNAQ5QU05, PUR7_IDILO
Q28PA0, PUR7_JANSCB5XVM9, PUR7_KLEP3A6TC99, PUR7_KLEP7
B3WFA0, PUR7_LACCBC4Z3J8, PUR7_LACE2O68830, PUR7_LACLA
Q9R7D5, PUR7_LACLCQ02Y52, PUR7_LACLSQ037U6, PUR7_LACP3
A9KQ90, PUR7_LACP7Q88U22, PUR7_LACPLQ38XX0, PUR7_LATSS
Q5X4M9, PUR7_LEGPAQ5WW20, PUR7_LEGPLQ6ACE5, PUR7_LEIXX
B1XWZ1, PUR7_LEPCPQ72UH8, PUR7_LEPICQ8F0I0, PUR7_LEPIN
B2GF71, PUR7_LIMF3Q92AN6, PUR7_LISINC1KW71, PUR7_LISMC
Q71YP6, PUR7_LISMFB8DDY5, PUR7_LISMHQ8Y6B9, PUR7_LISMO
A0AJM6, PUR7_LISW6B1HTV1, PUR7_LYSSCB9EAY5, PUR7_MACCJ
A0L4X9, PUR7_MAGMMQ65SH2, PUR7_MANSMQ0AQW2, PUR7_MARMM
A6VX88, PUR7_MARMSA1U1A4, PUR7_MARN8C6BVA6, PUR7_MARSD
Q8TIS9, PUR7_METACA7IAF5, PUR7_METB6Q46F30, PUR7_METBF
Q12UF8, PUR7_METBUQ60CQ5, PUR7_METCAQ1GZ28, PUR7_METFK
Q58987, PUR7_METJAQ8TX83, PUR7_METKAQ8PYK6, PUR7_METMA
A3CWL5, PUR7_METMJA2SCG5, PUR7_METPPA5UNH4, PUR7_METS3
O26272, PUR7_METTHB1MHW4, PUR7_MYCA9P0A5T5, PUR7_MYCBO
A1KGR3, PUR7_MYCBPC1ALB6, PUR7_MYCBTA4T7K2, PUR7_MYCGI
B8ZSW0, PUR7_MYCLBO08361, PUR7_MYCLEB2HH58, PUR7_MYCMM
A0R4I0, PUR7_MYCS2A3Q6D1, PUR7_MYCSJA1ULY1, PUR7_MYCSK
Q1B370, PUR7_MYCSSA5U0G8, PUR7_MYCTAP9WHN0, PUR7_MYCTO
P9WHN1, PUR7_MYCTUA0PLI0, PUR7_MYCUAA1TFF9, PUR7_MYCVP
B9L8V5, PUR7_NAUPAA9M3I9, PUR7_NEIM0Q9JV73, PUR7_NEIMA
Q9K063, PUR7_NEIMBQ2GCS7, PUR7_NEOSMQ82W32, PUR7_NITEU
A9A5G9, PUR7_NITMSQ3J871, PUR7_NITOCA6Q3C7, PUR7_NITSB
B2IWK4, PUR7_NOSP7Q8YUR7, PUR7_NOSS1Q2G9I7, PUR7_NOVAD
Q8ES99, PUR7_OCEIHQ04EU0, PUR7_OENOBA7HWB4, PUR7_PARL1
Q7U8Q9, PUR7_PARMWP57878, PUR7_PASMUQ6D7R1, PUR7_PECAS
C6DBS2, PUR7_PECCPQ03E76, PUR7_PEDPAB4SGP8, PUR7_PELPB
A1ATJ1, PUR7_PELPDQ4FLJ7, PUR7_PELUBC0QUE7, PUR7_PERMH
B4RHH0, PUR7_PHEZHQ7N3H3, PUR7_PHOLLQ96VP6, PUR7_PICAN
Q9C1J4, PUR7_PICPAA1VU36, PUR7_POLNAQ122N0, PUR7_POLSJ
Q7MVR8, PUR7_PORGIB4S8K9, PUR7_PROA2A2C4B2, PUR7_PROM1
A2C740, PUR7_PROM3A9BBW2, PUR7_PROM4Q7VAN8, PUR7_PROMA
B4EY76, PUR7_PROMHQ7V5X1, PUR7_PROMMQ7V0C7, PUR7_PROMP
Q46JC7, PUR7_PROMTQ48LD2, PUR7_PSE14Q15SZ6, PUR7_PSEA6
A6V9K1, PUR7_PSEA7B7UXT0, PUR7_PSEA8Q02IH8, PUR7_PSEAB
Q9I4W0, PUR7_PSEAEQ1I6H8, PUR7_PSEE4Q4KGP5, PUR7_PSEF5
C3KED7, PUR7_PSEFSA5VZX1, PUR7_PSEP1Q3KGI9, PUR7_PSEPF
B0KSY0, PUR7_PSEPGQ88NG9, PUR7_PSEPKB1JDB4, PUR7_PSEPW
Q87Y59, PUR7_PSESMQ4ZW72, PUR7_PSEU2Q4FVD4, PUR7_PSYA2
Q1QEF9, PUR7_PSYCKA1SVX4, PUR7_PSYINA5WHC5, PUR7_PSYWF
Q9V254, PUR7_PYRABQ8ZZK5, PUR7_PYRAEA3MXE4, PUR7_PYRCJ
Q8U4D5, PUR7_PYRFUO57978, PUR7_PYRHOQ8Y1W3, PUR7_RALN1
Q92PI3, PUR7_RHIMEA5V2F8, PUR7_RHIWRQ7UJ19, PUR7_RHOBA
B6IWP6, PUR7_RHOCSC0ZRJ1, PUR7_RHOE4Q0S784, PUR7_RHOJR
C1AT85, PUR7_RHOOBC3PMR4, PUR7_RICAEA8GML2, PUR7_RICAH
A8GVV0, PUR7_RICB8Q1RJ49, PUR7_RICBRA8EXW3, PUR7_RICCK
Q92IX6, PUR7_RICCNQ4UML8, PUR7_RICFEA8F0X7, PUR7_RICM5
O05946, PUR7_RICPRC4K0X5, PUR7_RICPUB0BWM7, PUR7_RICRO
A8GR81, PUR7_RICRSQ68XE9, PUR7_RICTYA7NKB4, PUR7_ROSCS
Q167J5, PUR7_ROSDOA5UWC5, PUR7_ROSS1Q5LS81, PUR7_RUEPO
Q21MZ8, PUR7_SACD2A4FQI3, PUR7_SACENQ9UX20, PUR7_SACS2
B5F0L3, PUR7_SALA4A8M3D4, PUR7_SALAIA9MHQ4, PUR7_SALAR
Q57LM4, PUR7_SALCHB5FQH7, PUR7_SALDCB5R4J4, PUR7_SALEP
B5RCV7, PUR7_SALG2B4TD62, PUR7_SALHSB4T0L4, PUR7_SALNS
Q5PLR9, PUR7_SALPAA9N2Z5, PUR7_SALPBC0PYS1, PUR7_SALPC
B5BB18, PUR7_SALPKB4TR59, PUR7_SALSVP65890, PUR7_SALTI
A4XB58, PUR7_SALTOP65889, PUR7_SALTYQ9UUB4, PUR7_SCHPO
A8GHL5, PUR7_SERP5A1S2U5, PUR7_SHEAMB8E8I2, PUR7_SHEB2
A3D944, PUR7_SHEB5A6WIQ6, PUR7_SHEB8A9KZH0, PUR7_SHEB9
Q12JN5, PUR7_SHEDOQ07WS1, PUR7_SHEFNB0TQY6, PUR7_SHEHH
Q8EA43, PUR7_SHEONA8H5E7, PUR7_SHEPAA4Y307, PUR7_SHEPC
B8CR57, PUR7_SHEPWA0L1C5, PUR7_SHESAQ0HEK4, PUR7_SHESM
Q0HZE8, PUR7_SHESRA1RNX8, PUR7_SHESWB2TXQ2, PUR7_SHIB3
Q31Y15, PUR7_SHIBSQ32D90, PUR7_SHIDSQ0T241, PUR7_SHIF8
P0A7E0, PUR7_SHIFLQ3YZ76, PUR7_SHISSC3MD65, PUR7_SINFN
A6U9L2, PUR7_SINMWQ2NS76, PUR7_SODGMQ1GVL7, PUR7_SPHAL
A7X0V7, PUR7_STAA1A6U0N4, PUR7_STAA2Q2FI12, PUR7_STAA3
Q2FZJ3, PUR7_STAA8A5IRV3, PUR7_STAA9Q2YX57, PUR7_STAAB
Q5HH18, PUR7_STAACA6QFS5, PUR7_STAAEP65891, PUR7_STAAM
P99064, PUR7_STAANQ6GI18, PUR7_STAARQ6GAE7, PUR7_STAAS
A8Z1K8, PUR7_STAATP65892, PUR7_STAAWB9DQ35, PUR7_STACT
Q5HQA4, PUR7_STAEQQ8CPP1, PUR7_STAESQ4L575, PUR7_STAHJ
Q49WJ0, PUR7_STAS1Q3K403, PUR7_STRA1Q8E7X2, PUR7_STRA3
Q8E2G4, PUR7_STRA5Q82FV6, PUR7_STRAWQ9RKL1, PUR7_STRCO
C0MAG2, PUR7_STRE4B4U5E5, PUR7_STREMA8AU96, PUR7_STRGC
B1VR40, PUR7_STRGGB4SLF7, PUR7_STRM5B2FKM0, PUR7_STRMK
Q8DWL6, PUR7_STRMUQ9A1Z3, PUR7_STRP1Q04N25, PUR7_STRP2
P0DD56, PUR7_STRP3B5E5J3, PUR7_STRP4Q5XEF7, PUR7_STRP6
C1C9U8, PUR7_STRP7Q8P315, PUR7_STRP8B1I7V1, PUR7_STRPI
B8ZJM7, PUR7_STRPJQ07296, PUR7_STRPNP0DD57, PUR7_STRPQ
Q8DRM7, PUR7_STRR6C0MCA1, PUR7_STRS7A3CJZ1, PUR7_STRSV
Q5M206, PUR7_STRT1Q5M6J8, PUR7_STRT2Q03N01, PUR7_STRTD
B9DSR1, PUR7_STRU0C1CBM0, PUR7_STRZJC1CHV6, PUR7_STRZP
C1CNS2, PUR7_STRZTQ4J8G0, PUR7_SULACQ30TB0, PUR7_SULDN
Q970V9, PUR7_SULTOQ3A5Q6, PUR7_SYNC1A0LHQ3, PUR7_SYNFM
Q2JXL8, PUR7_SYNJAQ2JKP0, PUR7_SYNJBB1XNE9, PUR7_SYNP2
A5GN71, PUR7_SYNPWQ0I808, PUR7_SYNS3Q3AZF6, PUR7_SYNS9
Q3AHS3, PUR7_SYNSCP73471, PUR7_SYNY3Q9HLC0, PUR7_THEAC
Q47KH4, PUR7_THEFYQ5JFN5, PUR7_THEKOQ9X0X0, PUR7_THEMA
A5IMW3, PUR7_THEP1B0KBQ8, PUR7_THEP3B0K3Q1, PUR7_THEPX
C6A0I8, PUR7_THESMB1LCA5, PUR7_THESQQ8DIT5, PUR7_THEVB
Q978V1, PUR7_THEVOB5YFN3, PUR7_THEYDB8GP39, PUR7_THISH
Q10VV0, PUR7_TRIEIB3E940, PUR7_TRIL1Q3MH17, PUR7_TRIV2
Q83IB9, PUR7_TROW8Q83GX1, PUR7_TROWTB7VMT0, PUR7_VIBA3
A7MVN0, PUR7_VIBC1Q9KSR6, PUR7_VIBCHQ87Q87, PUR7_VIBPA
Q8D915, PUR7_VIBVUQ7MLF9, PUR7_VIBVYQ07463, PUR7_VIGAC
Q8D2M4, PUR7_WIGBRQ73GD4, PUR7_WOLPMB3CM64, PUR7_WOLPP
Q7M9X5, PUR7_WOLSUQ5GT56, PUR7_WOLTRC0R444, PUR7_WOLWR
Q8PQ58, PUR7_XANACQ3BYD2, PUR7_XANC5Q4UZH5, PUR7_XANC8
B0RMY6, PUR7_XANCBQ8PD87, PUR7_XANCPQ2NYP3, PUR7_XANOM
B2SM33, PUR7_XANOPQ5GVG5, PUR7_XANORB2I6R9, PUR7_XYLF2
Q9PGU3, PUR7_XYLFAB0U1N3, PUR7_XYLFMQ87EX9, PUR7_XYLFT
P27616, PUR7_YEASTA1JL09, PUR7_YERE8A7FG51, PUR7_YERP3
Q1C5Q7, PUR7_YERPAB2K993, PUR7_YERPBQ8ZCD2, PUR7_YERPE
A9R2H1, PUR7_YERPGQ1CK24, PUR7_YERPNA4TMM9, PUR7_YERPP
Q668F9, PUR7_YERPSB1JSG7, PUR7_YERPYQ5NNN4, PUR7_ZYMMO
Q54QE4, PURCE_DICDI

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-