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ENZYME entry: EC 6.3.2.61

Accepted Name
tubulin-glutamate ligase.
Alternative Name(s)
alpha-tubulin-glutamate ligase.
tubulin polyglutamylase.
Reaction catalysed
n ATP + [tubulin]-L-glutamate + n L-glutamate <=> [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
Comment(s)
  • The eukaryotic tubulin proteins, which polymerize into microtubules, are highly modified by the addition of side-chains.
  • The polyglutamylation reaction catalyzed by this group of enzymes consists of two biochemically distinct steps: initiation and elongation.
  • Initiation comprises the formation of an isopeptide bond with the gamma-carboxyl group of the glutamate acceptor site in a glutamate- rich C-terminal region of tubulin, whereas elongation consists of the addition of glutamate residues linked by regular peptide bonds to the gamma-linked residue.
  • This entry describes enzymes that act on both alpha- and beta- tubulins.
Cross-references
BRENDA6.3.2.61
EC2PDB6.3.2.61
ExplorEnz6.3.2.61
PRIAM enzyme-specific profiles6.3.2.61
KEGG Ligand Database for Enzyme Nomenclature6.3.2.61
IUBMB Enzyme Nomenclature6.3.2.61
IntEnz6.3.2.61
MEDLINEFind literature relating to 6.3.2.61
MetaCyc6.3.2.61
Rhea expert-curated reactions6.3.2.61

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
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