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ENZYME

ENZYME entry: EC 6.3.2.7

Accepted Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
Alternative Name(s)
L-lysine-adding enzyme
MurE synthetase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase
UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase
uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase
Reaction catalysed
ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
Comment(s)
  • Involved in the synthesis of a cell-wall peptide.
  • This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 adds 2,6-diaminopimelate instead.
Cross-references
BRENDA6.3.2.7
EC2PDB6.3.2.7
ExplorEnz6.3.2.7
PRIAM enzyme-specific profiles6.3.2.7
KEGG Ligand Database for Enzyme Nomenclature6.3.2.7
IUBMB Enzyme Nomenclature6.3.2.7
IntEnz6.3.2.7
MEDLINEFind literature relating to 6.3.2.7
MetaCyc6.3.2.7
Rhea expert-curated reactions6.3.2.7
UniProtKB/Swiss-Prot
Q838A4, MURE_ENTFAA7X0P6, MURE_STAA1Q2FI59, MURE_STAA3
Q2FZP6, MURE_STAA8Q2YWY9, MURE_STAABO86491, MURE_STAAC
P65479, MURE_STAAMP65480, MURE_STAANQ6GI66, MURE_STAAR
Q6GAQ9, MURE_STAASQ8NXC2, MURE_STAAWQ5HQE6, MURE_STAEQ
Q8CPR2, MURE_STAESQ4L525, MURE_STAHJQ3K0C1, MURE_STRA1
Q8E4E0, MURE_STRA3Q8DYT2, MURE_STRA5Q8DST2, MURE_STRMU
Q9A196, MURE_STRP1Q04JL8, MURE_STRP2P0DC54, MURE_STRP3
Q5XDM7, MURE_STRP6Q8P2B4, MURE_STRP8Q1JN87, MURE_STRPC
Q1JID8, MURE_STRPDQ1J890, MURE_STRPFA2RG75, MURE_STRPG
Q48V28, MURE_STRPMQ97PS1, MURE_STRPNP0DC55, MURE_STRPQ
Q8CWQ5, MURE_STRR6A4W0C1, MURE_STRS2A3CPL6, MURE_STRSV
A4VU28, MURE_STRSYQ5M1B4, MURE_STRT1Q5M5V0, MURE_STRT2
Q03M85, MURE_STRTDQ9WY79, MURE_THEMA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
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