ENZYME entry: EC 6.3.2.7

Accepted Name

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase

Alternative Name(s)

L-lysine-adding enzyme

MurE synthetase

UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase

UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase

uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase

Reaction catalysed

ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine

Comment(s)

Involved in the synthesis of a cell-wall peptide.
This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 adds 2,6-diaminopimelate instead.

Cross-references

BRENDA

6.3.2.7

EC2PDB

6.3.2.7

ExplorEnz

6.3.2.7

PRIAM enzyme-specific profiles

6.3.2.7

KEGG Ligand Database for Enzyme Nomenclature

6.3.2.7

IUBMB Enzyme Nomenclature

6.3.2.7

IntEnz

6.3.2.7

MEDLINE

Find literature relating to 6.3.2.7

MetaCyc

6.3.2.7

Rhea expert-curated reactions

6.3.2.7

UniProtKB/Swiss-Prot

Q838A4, MURE_ENTFA	A7X0P6, MURE_STAA1	Q2FI59, MURE_STAA3
Q2FZP6, MURE_STAA8	Q2YWY9, MURE_STAAB	O86491, MURE_STAAC
P65479, MURE_STAAM	P65480, MURE_STAAN	Q6GI66, MURE_STAAR
Q6GAQ9, MURE_STAAS	Q8NXC2, MURE_STAAW	Q5HQE6, MURE_STAEQ
Q8CPR2, MURE_STAES	Q4L525, MURE_STAHJ	Q3K0C1, MURE_STRA1
Q8E4E0, MURE_STRA3	Q8DYT2, MURE_STRA5	Q8DST2, MURE_STRMU
Q9A196, MURE_STRP1	Q04JL8, MURE_STRP2	P0DC54, MURE_STRP3
Q5XDM7, MURE_STRP6	Q8P2B4, MURE_STRP8	Q1JN87, MURE_STRPC
Q1JID8, MURE_STRPD	Q1J890, MURE_STRPF	A2RG75, MURE_STRPG
Q48V28, MURE_STRPM	Q97PS1, MURE_STRPN	P0DC55, MURE_STRPQ
Q8CWQ5, MURE_STRR6	A4W0C1, MURE_STRS2	A3CPL6, MURE_STRSV
A4VU28, MURE_STRSY	Q5M1B4, MURE_STRT1	Q5M5V0, MURE_STRT2
Q03M85, MURE_STRTD	Q9WY79, MURE_THEMA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
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