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ENZYME

ENZYME entry: EC 6.3.4.22

PURL: https://purl.expasy.org/enzyme/EC/6.3.4.22
Accepted Name
tRNA(Ile)(2)-agmatinylcytidine synthase
Alternative Name(s)
tRNA(Ile)-2-agmatinylcytidine synthetase
tRNA(Ile)-agm(2)C synthetase
tRNA(Ile)-agmatidine synthetase
Reaction catalysed
cytidine(34) in tRNA(Ile2) + agmatine + ATP + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 phosphate + 2 H(+)
Comment(s)
  • The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNA(Ile)(2) at the oxo group in position 2 of cytidine(34).
  • This modification is crucial for accurate decoding of the genetic code.
  • In bacteria EC 6.3.4.19, catalyzes the modification of [tRNA(Ile)(2)]-cytidine(34) to [tRNA(Ile)(2)]-lysidine(34).
Cross-references
BRENDA6.3.4.22
EC2PDB6.3.4.22
ExplorEnz6.3.4.22
KEGG Ligand Database for Enzyme Nomenclature6.3.4.22
IUBMB Enzyme Nomenclature6.3.4.22
MEDLINEFind literature relating to 6.3.4.22
MetaCyc6.3.4.22
Rhea expert-curated reactions6.3.4.22
UniProtKB/Swiss-Prot
D9Q2C4, TIAS_ACIS3O28025, TIAS_ARCFUA8MA77, TIAS_CALMQ
A0RZ60, TIAS_CENSYQ18FU7, TIAS_HALWDA2BIT1, TIAS_HYPBU
E0SPG5, TIAS_IGNAAA8A990, TIAS_IGNH4Q8TK89, TIAS_METAC
Q58495, TIAS_METJAQ8TWM9, TIAS_METKAA2SPT0, TIAS_METLZ
Q8PZP7, TIAS_METMAD7DRZ8, TIAS_METV3O59476, TIAS_PYRHO
B1YAA9, TIAS_PYRNVC3MRH3, TIAS_SACI2A3DP93, TIAS_STAMF
C5A5L9, TIAS_THEGJA1RXS9, TIAS_THEPDC6A3Q6, TIAS_THESM
Q97B59, TIAS_THEVO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-