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ENZYME

ENZYME entry: EC 6.3.4.3

Accepted Name
formate--tetrahydrofolate ligase
Alternative Name(s)
formyltetrahydrofolate synthetase
tetrahydrofolate formylase
tetrahydrofolic formylase
Reaction catalysed
(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-formyltetrahydrofolate + ADP + phosphate
Comment(s)
In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.
Cross-references
BRENDA6.3.4.3
EC2PDB6.3.4.3
ExplorEnz6.3.4.3
PRIAM enzyme-specific profiles6.3.4.3
KEGG Ligand Database for Enzyme Nomenclature6.3.4.3
IUBMB Enzyme Nomenclature6.3.4.3
IntEnz6.3.4.3
MEDLINEFind literature relating to 6.3.4.3
MetaCyc6.3.4.3
Rhea expert-curated reactions6.3.4.3
UniProtKB/Swiss-Prot
O96553, C1TC_DROMEP11586, C1TC_HUMANQ922D8, C1TC_MOUSE
Q5R8P0, C1TC_PONABP27653, C1TC_RATQ8WZJ7, C1TC_SCHPO
Q27772, C1TC_SPOFRP07245, C1TC_YEASTQ0VCR7, C1TM_BOVIN
Q6UB35, C1TM_HUMANQ3V3R1, C1TM_MOUSEO43007, C1TM_SCHPO
P09440, C1TM_YEASTQ251P8, FTHS1_DESHYQ5FJY2, FTHS1_LACAC
Q1AXZ4, FTHS1_RUBXDQ99ZI9, FTHS1_STRP1P0DF90, FTHS1_STRP3
Q5XC12, FTHS1_STRP6Q8P0X5, FTHS1_STRP8Q1JBM0, FTHS1_STRPB
Q1JLK2, FTHS1_STRPCQ1JGN8, FTHS1_STRPDQ1J6F7, FTHS1_STRPF
A2REC4, FTHS1_STRPGQ48TE8, FTHS1_STRPMP0DF91, FTHS1_STRPQ
A3CL27, FTHS1_STRSVQ24ZZ8, FTHS2_DESHYQ5FIU5, FTHS2_LACAC
Q1AVP8, FTHS2_RUBXDQ99XR2, FTHS2_STRP1P0DF92, FTHS2_STRP3
Q5X9K7, FTHS2_STRP6Q8NZ49, FTHS2_STRP8Q1J9F2, FTHS2_STRPB
Q1JJK1, FTHS2_STRPCQ1JEK4, FTHS2_STRPDQ1J4C0, FTHS2_STRPF
A2RGS2, FTHS2_STRPGQ48QZ2, FTHS2_STRPMP0DF93, FTHS2_STRPQ
A3CN49, FTHS2_STRSVQ1AT39, FTHS3_RUBXDA3DI22, FTHS_ACET2
A9NE95, FTHS_ACHLIA5G276, FTHS_ACICJA3MZI4, FTHS_ACTP2
B3GX43, FTHS_ACTP7A0KIN9, FTHS_AERHHA4SPE5, FTHS_AERS4
C4ZBG8, FTHS_AGARVQ5E3V8, FTHS_ALIF1B5FG96, FTHS_ALIFM
B6EIJ9, FTHS_ALISLA8MIN1, FTHS_ALKOOB9JZN5, FTHS_ALLAM
Q9SPK5, FTHS_ARATHA0JZ10, FTHS_ARTS2C3P858, FTHS_BACAA
C3LKJ6, FTHS_BACACA0RD97, FTHS_BACAHQ81RE1, FTHS_BACAN
B7JLG8, FTHS_BACC0Q739F4, FTHS_BACC1B7IUA4, FTHS_BACC2
C1ES77, FTHS_BACC3B7HP29, FTHS_BACC7B9IYP4, FTHS_BACCQ
Q81E87, FTHS_BACCRQ63C61, FTHS_BACCZQ5LD60, FTHS_BACFN
Q64U80, FTHS_BACFRQ6HJK9, FTHS_BACHKQ65IA6, FTHS_BACLD
A8FEC9, FTHS_BACP2Q8A9S8, FTHS_BACTNA9IM41, FTHS_BART1
B2IC30, FTHS_BEII9Q8G700, FTHS_BIFLOC0QX38, FTHS_BRAHW
B9MM59, FTHS_CALBDQ8R7L3, FTHS_CALS4A4XIU2, FTHS_CALS8
A8Z6G1, FTHS_CAMC1A7GZZ0, FTHS_CAMC5Q3A9K2, FTHS_CARHZ
A3PM52, FTHS_CERS1Q3J047, FTHS_CERS4A4WQ11, FTHS_CERS5
B9KLK4, FTHS_CERSKQ11G79, FTHS_CHESBA9WIW3, FTHS_CHLAA
B8GC03, FTHS_CHLADB9LKW0, FTHS_CHLSYQ97EB3, FTHS_CLOAB
P13419, FTHS_CLOACA7FZB0, FTHS_CLOB1C3KVU4, FTHS_CLOB6
A6LPL1, FTHS_CLOB8B2UXU5, FTHS_CLOBAB2TI29, FTHS_CLOBB
A5I7P9, FTHS_CLOBHC1FND0, FTHS_CLOBJB1IGY1, FTHS_CLOBK
A7GJB8, FTHS_CLOBLB1KTC6, FTHS_CLOBMQ07064, FTHS_CLOCY
Q189R2, FTHS_CLOD6B9DYW1, FTHS_CLOK1A5N5B3, FTHS_CLOK5
A0PXN0, FTHS_CLONNQ0TMI3, FTHS_CLOP1Q8XHL4, FTHS_CLOPE
Q0SQ82, FTHS_CLOPSQ891R3, FTHS_CLOTEQ6NH87, FTHS_CORDI
Q4JVW2, FTHS_CORJKQ6ABS5, FTHS_CUTAKQ3Z8K3, FTHS_DEHM1
Q3ZX40, FTHS_DEHMCC0QAX9, FTHS_DESAHB8FGU7, FTHS_DESAL
B8J0C2, FTHS_DESDAA8ZZJ0, FTHS_DESOHQ6AL19, FTHS_DESPS
A4J0S6, FTHS_DESRMA8LIR1, FTHS_DINSHB2KDK9, FTHS_ELUMP
Q834D6, FTHS_ENTFAA7HLZ4, FTHS_FERNBB0S0G1, FTHS_FINM2
Q8RHF4, FTHS_FUSNNQ0BW57, FTHS_GRABCQ7VLW6, FTHS_HAEDU
Q5V5Y2, FTHS_HALMAB8D067, FTHS_HALOHQ18JB5, FTHS_HALWD
B0TBP1, FTHS_HELMIA9B4H8, FTHS_HERA2Q0BX04, FTHS_HYPNA
Q28TR4, FTHS_JANSCC5CI89, FTHS_KOSOTB3WEG3, FTHS_LACCB
Q1GA94, FTHS_LACDAQ04AM0, FTHS_LACDBC4Z1V6, FTHS_LACE2
Q043I0, FTHS_LACGAQ74JC1, FTHS_LACJOQ9CH07, FTHS_LACLA
A2RLK1, FTHS_LACLMQ02ZS7, FTHS_LACLSQ038Y4, FTHS_LACP3
A9KNJ5, FTHS_LACP7Q88W76, FTHS_LACPLQ38X32, FTHS_LATSS
Q1MPZ9, FTHS_LAWIPB1MY45, FTHS_LEUCKQ03YB1, FTHS_LEUMM
Q03S45, FTHS_LEVBAQ1WTW0, FTHS_LIGS1B2GF64, FTHS_LIMF3
A5VHS9, FTHS_LIMRDB2G5A9, FTHS_LIMRJQ92AD2, FTHS_LISIN
C1KWH6, FTHS_LISMCQ71YD9, FTHS_LISMFB8DDM6, FTHS_LISMH
Q8Y624, FTHS_LISMOA0AJY2, FTHS_LISW6Q8EUQ1, FTHS_MALP2
Q0APT3, FTHS_MARMMB7L0A5, FTHS_METC4Q605Q9, FTHS_METCA
Q83WS0, FTHS_METEAA9VZT0, FTHS_METEPQ1GZ16, FTHS_METFK
A2SS72, FTHS_METLZB8IBS4, FTHS_METNOB1ZJ88, FTHS_METPB
A2SKX8, FTHS_METPPB1M0D1, FTHS_METRJB0UQF5, FTHS_METS4
B8EKB9, FTHS_METSBQ2RM91, FTHS_MOOTAP21164, FTHS_MOOTH
Q1DFW5, FTHS_MYXXDB2A3Q6, FTHS_NATTJQ5FAG1, FTHS_NEIG1
B4RP08, FTHS_NEIG2A9M1J1, FTHS_NEIM0Q9JVY8, FTHS_NEIMA
Q9JXY2, FTHS_NEIMBA1KS57, FTHS_NEIMFA1SQH3, FTHS_NOCSJ
Q04FS6, FTHS_OENOBA1R8N9, FTHS_PAEATA6LAR6, FTHS_PARD8
A1B1M8, FTHS_PARDPQ03FM6, FTHS_PEDPAQ4FL49, FTHS_PELUB
Q5XZD9, FTHS_PEPACA9BIV8, FTHS_PETMOQ6LNJ0, FTHS_PHOPR
A6L4P0, FTHS_PHOV8Q6KZM3, FTHS_PICTOQ7MUZ8, FTHS_PORGI
B4ET09, FTHS_PROMHA8F7D5, FTHS_PSELTA5WI04, FTHS_PSYWF
A9WMW3, FTHS_RENSMB3PV59, FTHS_RHIE6Q2K5P2, FTHS_RHIEC
Q1MDG4, FTHS_RHIJ3Q98HQ4, FTHS_RHILOB5ZYA2, FTHS_RHILW
Q92N42, FTHS_RHIMEB9J7E8, FTHS_RHIR8A7NGQ9, FTHS_ROSCS
Q160C2, FTHS_ROSDOA5UPV2, FTHS_ROSS1Q5LNV0, FTHS_RUEPO
Q1GE26, FTHS_RUESTB8I3S9, FTHS_RUMCHA4FL80, FTHS_SACEN
A1SAE2, FTHS_SHEAMB8ECE1, FTHS_SHEB2A3CZY6, FTHS_SHEB5
A6WSY9, FTHS_SHEB8A9L3Z6, FTHS_SHEB9B0TVP3, FTHS_SHEHH
A3QA17, FTHS_SHELPQ8EJA7, FTHS_SHEONA8H8Z4, FTHS_SHEPA
A4YAP3, FTHS_SHEPCB8CI99, FTHS_SHEPWA0KSN0, FTHS_SHESA
A8FQV1, FTHS_SHESHQ0HMS6, FTHS_SHESMQ0HR05, FTHS_SHESR
A1RFN3, FTHS_SHESWB1KJC0, FTHS_SHEWMC3MFQ8, FTHS_SINFN
A6UBV0, FTHS_SINMWO66164, FTHS_SPHSKP28723, FTHS_SPIOL
A7X3G5, FTHS_STAA1A6U2J8, FTHS_STAA2Q2FG06, FTHS_STAA3
Q2G296, FTHS_STAA8A5ITQ4, FTHS_STAA9Q2YTF6, FTHS_STAAB
Q5HF42, FTHS_STAACA6QHR5, FTHS_STAAEQ99TD2, FTHS_STAAM
Q7A535, FTHS_STAANQ6GFX6, FTHS_STAARQ6G8J5, FTHS_STAAS
A8Z2Q0, FTHS_STAATQ8NW37, FTHS_STAAWB9DN77, FTHS_STACT
Q5HNH4, FTHS_STAEQQ8CNV9, FTHS_STAESQ4L776, FTHS_STAHJ
Q3K138, FTHS_STRA1Q8E5E3, FTHS_STRA3Q8DZP5, FTHS_STRA5
C0M9N3, FTHS_STRE4B4U2T6, FTHS_STREMQ59925, FTHS_STRMU
Q04K90, FTHS_STRP2B5E4W4, FTHS_STRP4C1C7J4, FTHS_STRP7
B1IC26, FTHS_STRPIB8ZJQ0, FTHS_STRPJQ97QI2, FTHS_STRPN
B2IPQ3, FTHS_STRPSQ8DPL5, FTHS_STRR6A4W0G0, FTHS_STRS2
C0MFU5, FTHS_STRS7A4VU67, FTHS_STRSYQ5M083, FTHS_STRT1
Q5M4U2, FTHS_STRT2Q03L41, FTHS_STRTDB9DS83, FTHS_STRU0
C1CEI6, FTHS_STRZJC1CKW9, FTHS_STRZPC1CR74, FTHS_STRZT
Q67JH9, FTHS_SYMTHQ2LU82, FTHS_SYNASA0LLR3, FTHS_SYNFM
Q0AX38, FTHS_SYNWWB7IG29, FTHS_THEABQ9HI67, FTHS_THEAC
A6LJS5, FTHS_THEM4Q9X287, FTHS_THEMAA5ILJ8, FTHS_THEP1
B0KC36, FTHS_THEP3B0K5A5, FTHS_THEPXB1LAQ7, FTHS_THESQ
Q72GY9, FTHS_THET2Q97CL3, FTHS_THEVOB5YJE1, FTHS_THEYD
Q73RR6, FTHS_TREDEQ9PQS1, FTHS_UREPAB7VSJ2, FTHS_VIBA3
A7N5E9, FTHS_VIBC1Q9KLX7, FTHS_VIBCHQ87HX2, FTHS_VIBPA
Q8D7D8, FTHS_VIBVUQ7MEE8, FTHS_VIBVYA1JMA3, FTHS_YERE8
Q5NQC7, FTHS_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-