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ENZYME entry: EC 6.3.5.10

Accepted Name
Adenosylcobyric acid synthase (glutamine-hydrolyzing).
Alternative Name(s)
5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase.
Ado-cobyric acid synthase (glutamine hydrolyzing).
Cobyric acid synthase.
Reaction catalysed
4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H(2)O <=> 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate
Cofactor(s)
Mg(2+).
Comment(s)
  • NH(3) can act instead of glutamine.
  • This enzyme catalyzes the four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of cobyrinic acid triamide, tetraamide and pentaamide intermediates.
Cross-references
BRENDA6.3.5.10
EC2PDB6.3.5.10
ExplorEnz6.3.5.10
PRIAM enzyme-specific profiles6.3.5.10
KEGG Ligand Database for Enzyme Nomenclature6.3.5.10
IUBMB Enzyme Nomenclature6.3.5.10
IntEnz6.3.5.10
MEDLINEFind literature relating to 6.3.5.10
MetaCyc6.3.5.10
Rhea expert-curated reactions6.3.5.10

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-