ENZYME entry: EC 6.3.5.10

Accepted Name
adenosylcobyric acid synthase (glutamine-hydrolyzing)
Alternative Name(s)
5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase
Ado-cobyric acid synthase [glutamine hydrolyzing]
cobyric acid synthase
Reaction catalysed
adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine <=> adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate
Comment(s)
NH3 can act instead of glutamine. This enzyme catalyzes the four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of cobyrinic acid triamide, tetraamide and pentaamide intermediates.
Cross-references
BRENDA	6.3.5.10
EC2PDB	6.3.5.10
ExplorEnz	6.3.5.10
PRIAM enzyme-specific profiles	6.3.5.10
KEGG Ligand Database for Enzyme Nomenclature	6.3.5.10
IUBMB Enzyme Nomenclature	6.3.5.10
IntEnz	6.3.5.10
MEDLINE	Find literature relating to 6.3.5.10
MetaCyc	6.3.5.10
Rhea expert-curated reactions	6.3.5.10

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