ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 6.3.5.10

Accepted Name
Adenosylcobyric acid synthase (glutamine-hydrolyzing).
Alternative Name(s)
5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase.
Ado-cobyric acid synthase (glutamine hydrolyzing).
Cobyric acid synthase.
Reaction catalysed
4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H(2)O <=> 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate
Cofactor(s)
Mg(2+).
Comment(s)
NH(3) can act instead of glutamine. This enzyme catalyzes the four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of cobyrinic acid triamide, tetraamide and pentaamide intermediates.
Cross-references
BRENDA	6.3.5.10
EC2PDB	6.3.5.10
ExplorEnz	6.3.5.10
PRIAM enzyme-specific profiles	6.3.5.10
KEGG Ligand Database for Enzyme Nomenclature	6.3.5.10
IUBMB Enzyme Nomenclature	6.3.5.10
IntEnz	6.3.5.10
MEDLINE	Find literature relating to 6.3.5.10
MetaCyc	6.3.5.10

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