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ENZYME

ENZYME entry: EC 6.3.5.2

Accepted Name
GMP synthase (glutamine-hydrolyzing)
Alternative Name(s)
GMP synthetase (glutamine-hydrolyzing)
Reaction catalysed
ATP + H2O + L-glutamine + XMP <=> AMP + diphosphate + GMP + 2 H(+) + L-glutamate
Comment(s)
  • Involved in the de novo biosynthesis of guanosine nucleotides.
  • An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain.
  • The enzyme can catalyze the second reaction alone in the presence of ammonia.
  • Formerly EC 6.3.4.1.
Cross-references
BRENDA6.3.5.2
EC2PDB6.3.5.2
ExplorEnz6.3.5.2
PRIAM enzyme-specific profiles6.3.5.2
KEGG Ligand Database for Enzyme Nomenclature6.3.5.2
IUBMB Enzyme Nomenclature6.3.5.2
IntEnz6.3.5.2
MEDLINEFind literature relating to 6.3.5.2
MetaCyc6.3.5.2
Rhea expert-curated reactions6.3.5.2
UniProtKB/Swiss-Prot
Q89ZV6, GUAA1_BACTNQ8A525, GUAA2_BACTNO28949, GUAAA_ARCFU
Q5V1K0, GUAAA_HALMAQ9HSH4, GUAAA_HALSAQ18KM8, GUAAA_HALWD
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Q12UJ5, GUAAA_METBUQ2FL30, GUAAA_METHJQ58970, GUAAA_METJA
Q8TXV8, GUAAA_METKAA4FW79, GUAAA_METM5A9A9L8, GUAAA_METM6
A6VH31, GUAAA_METM7Q8PXF0, GUAAA_METMAA3CTG9, GUAAA_METMJ
Q6LXA7, GUAAA_METMPA5UK20, GUAAA_METS3Q2NER5, GUAAA_METST
O26805, GUAAA_METTHA0B5J1, GUAAA_METTPA6UQ90, GUAAA_METVS
Q3ITY2, GUAAA_NATPDQ6KZC5, GUAAA_PICTOQ9V0I6, GUAAA_PYRAB
Q8U0R9, GUAAA_PYRFUO59071, GUAAA_PYRHOQ97VZ9, GUAAA_SACS2
Q8X239, GUAAA_SULACQ974T4, GUAAA_SULTOQ9HJM3, GUAAA_THEAC
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Q8PXK0, GUAAB_METMAA3CWS6, GUAAB_METMJQ6LYU3, GUAAB_METMP
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O66601, GUAA_AQUAEQ5NYE5, GUAA_AROAEQ4WFT3, GUAA_ASPFU
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P60499, GUAA_CORDIQ8FRZ3, GUAA_COREFA4QBV0, GUAA_CORGB
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Q2GHY2, GUAA_EHRCRQ5FF75, GUAA_EHRRGQ5HCA2, GUAA_EHRRW
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Q839J8, GUAA_ENTFAQ756B7, GUAA_EREGSB7LKD4, GUAA_ESCF3
B1YIZ1, GUAA_EXIS2B0S0S7, GUAA_FINM2A5FHB4, GUAA_FLAJ1
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Q5NG38, GUAA_FRATTA4IXW6, GUAA_FRATWP83540, GUAA_FRUSA
Q8RDR4, GUAA_FUSNNC1A3W7, GUAA_GEMATB9M9G4, GUAA_GEODF
Q5L3E1, GUAA_GEOKAQ39TA7, GUAA_GEOMGP60500, GUAA_GEOSL
Q4HXF0, GUAA_GIBZEB8F3T2, GUAA_GLAP5B7K8T7, GUAA_GLOC7
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B5XNM4, GUAA_KLEP3A6TCC2, GUAA_KLEP7Q6CU71, GUAA_KLULA
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Q04CA4, GUAA_LACDBC4Z3X1, GUAA_LACE2Q046I2, GUAA_LACGA
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