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ENZYME

ENZYME entry: EC 6.4.1.11

PURL: https://purl.expasy.org/enzyme/EC/6.4.1.11
Accepted Name
polyporic acid synthase
Reaction catalysed
2 3-phenylpyruvate + 2 ATP = polyporic acid + 2 AMP + 2 diphosphate + H(+)
Comment(s)
  • Requires Mg(2+).
  • The enzyme, found in mushrooms of the Basidiomycota and Ascomycota phyla, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain.
  • The enzyme activates 3-phenyl-2-oxopropanoate by adenylation and catalyzes the dimerization/cyclization of two such molecules to form polyporic acid.
  • Polyporic acid is a precursor for assorted metabolites produced by the fungi, such as the corticins.
Cross-references
BRENDA6.4.1.11
EC2PDB6.4.1.11
ExplorEnz6.4.1.11
KEGG Ligand Database for Enzyme Nomenclature6.4.1.11
IUBMB Enzyme Nomenclature6.4.1.11
MEDLINEFind literature relating to 6.4.1.11
MetaCyc6.4.1.11
Rhea expert-curated reactions6.4.1.11

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-