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ENZYME entry: EC 6.4.1.7

Accepted Name
2-oxoglutarate carboxylase.
Alternative Name(s)
Carboxylating factor for ICDH.
CFI.
OGC.
Oxalosuccinate synthetase.
Reaction catalysed
ATP + 2-oxoglutarate + HCO(3)(-) <=> ADP + phosphate + oxalosuccinate
Cofactor(s)
Biotin; Mg(2+).
Comment(s)
  • It was originally thought that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC 1.1.1.41, but this has since been disproved.
  • The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41.
Cross-references
PROSITEPDOC00676 ; PDOC50975
BRENDA6.4.1.7
EC2PDB6.4.1.7
ExplorEnz6.4.1.7
PRIAM enzyme-specific profiles6.4.1.7
KEGG Ligand Database for Enzyme Nomenclature6.4.1.7
IUBMB Enzyme Nomenclature6.4.1.7
IntEnz6.4.1.7
MEDLINEFind literature relating to 6.4.1.7
MetaCyc6.4.1.7
Rhea expert-curated reactions6.4.1.7
UniProtKB/Swiss-Prot
D3DJ41, 2OCL_HYDTT;  D3DJ42, 2OCS_HYDTT;  

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