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ENZYME entry: EC 7.2.2.19

Accepted Name
H(+)/K(+)-exchanging ATPase.
Alternative Name(s)
Gastric H(+)/K(+) ATPase.
H(+)/K(+)-ATPase.
Potassium-transporting ATPase.
Proton pump.
Reaction catalysed
ATP + H(2)O + H(+)(Side 1) + K(+)(Side 2) <=> ADP + phosphate + H(+)(Side 2) + K(+)(Side 1)
Cofactor(s)
Mg(2+).
Comment(s)
  • A P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • A gastric mucosal enzyme that catalyzes the efflux of one H(+) and the influx of one K(+) per ATP hydrolyzed.
  • Formerly EC 3.6.1.36 and EC 3.6.3.10.
Cross-references
PROSITEPDOC00139
BRENDA7.2.2.19
EC2PDB7.2.2.19
ExplorEnz7.2.2.19
PRIAM enzyme-specific profiles7.2.2.19
KEGG Ligand Database for Enzyme Nomenclature7.2.2.19
IUBMB Enzyme Nomenclature7.2.2.19
IntEnz7.2.2.19
MEDLINEFind literature relating to 7.2.2.19
MetaCyc7.2.2.19
Rhea expert-curated reactions7.2.2.19
UniProtKB/Swiss-Prot
Q64392, AT12A_CAVPO;  P54707, AT12A_HUMAN;  Q9Z1W8, AT12A_MOUSE;  
Q9TV52, AT12A_RABIT;  P54708, AT12A_RAT;  Q92036, AT12A_RHIMB;  
P50996, ATP4A_CANLF;  P20648, ATP4A_HUMAN;  Q64436, ATP4A_MOUSE;  
P19156, ATP4A_PIG;  P27112, ATP4A_RABIT;  P09626, ATP4A_RAT;  
Q92126, ATP4A_XENLA;  

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