ENZYME entry: EC 7.2.2.19
Accepted Name |
H(+)/K(+)-exchanging ATPase.
|
Alternative Name(s) |
Gastric H(+)/K(+) ATPase. |
H(+)/K(+)-ATPase. |
Potassium-transporting ATPase. |
Proton pump. |
Reaction catalysed |
ATP + H(2)O + H(+)(Side 1) + K(+)(Side 2) <=> ADP + phosphate + H(+)(Side 2) + K(+)(Side 1) |
Cofactor(s) |
Mg(2+).
|
Comment(s) |
- A P-type ATPase that undergoes covalent phosphorylation during the
transport cycle.
- A gastric mucosal enzyme that catalyzes the efflux of one H(+) and
the influx of one K(+) per ATP hydrolyzed.
- Formerly EC 3.6.1.36 and EC 3.6.3.10.
|
Cross-references |
PROSITE | PDOC00139 |
BRENDA | 7.2.2.19 |
EC2PDB | 7.2.2.19 |
ExplorEnz | 7.2.2.19 |
PRIAM enzyme-specific profiles | 7.2.2.19 |
KEGG Ligand Database for Enzyme Nomenclature | 7.2.2.19 |
IUBMB Enzyme Nomenclature | 7.2.2.19 |
IntEnz | 7.2.2.19 |
MEDLINE | Find literature relating to 7.2.2.19 |
MetaCyc | 7.2.2.19 |
Rhea expert-curated reactions | 7.2.2.19 |
UniProtKB/Swiss-Prot |
Q64392, AT12A_CAVPO; | P54707, AT12A_HUMAN; | Q9Z1W8, AT12A_MOUSE; |
Q9TV52, AT12A_RABIT; | P54708, AT12A_RAT; | Q92036, AT12A_RHIMB; |
P50996, ATP4A_CANLF; | P20648, ATP4A_HUMAN; | Q64436, ATP4A_MOUSE; |
P19156, ATP4A_PIG; | P27112, ATP4A_RABIT; | P09626, ATP4A_RAT; |
Q92126, ATP4A_XENLA; |
|
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