ENZYME entry: EC 1.1.1.300

Accepted Name
NADP-retinol dehydrogenase.
Alternative Name(s)
All-trans retinal reductase.
All-trans-retinol dehydrogenase.
NADP(H)-dependent retinol dehydrogenase/reductase.
Retinol dehydrogenase (NADP(+)).
Reaction catalysed
All-trans-retinol + NADP(+) <=> all-trans-retinal + NADPH
Comment(s)
  • Greater catalytic efficiency in the reductive direction.
  • This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.14.99.36.
  • Km-values for NADP(+) and NADPH are at least 800-fold lower than those for NAD(+) and NADH.
  • This enzyme differs from EC 1.1.1.105 which prefers NAD(+) and NADH.
  • Formerly EC 1.1.1.n2.
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.300
EC2PDB1.1.1.300
ExplorEnz1.1.1.300
PRIAM enzyme-specific profiles1.1.1.300
KEGG Ligand Database for Enzyme Nomenclature1.1.1.300
IUBMB Enzyme Nomenclature1.1.1.300
IntEnz1.1.1.300
MEDLINEFind literature relating to 1.1.1.300
MetaCyc1.1.1.300
UniProtKB/Swiss-Prot
O77769, DHRS3_BOVIN;  O75911, DHRS3_HUMAN;  O88876, DHRS3_MOUSE;  
A1L1W4, RD10A_DANRE;  Q6DCT3, RD10A_XENLA;  Q7T2D1, RD10B_DANRE;  
Q6NRV4, RD10B_XENLA;  Q8HZT6, RDH10_BOVIN;  Q8IZV5, RDH10_HUMAN;  
Q8VCH7, RDH10_MOUSE;  Q80ZF7, RDH10_RAT;  Q5XGF7, RDH10_XENTR;  
Q8TC12, RDH11_HUMAN;  Q9QYF1, RDH11_MOUSE;  Q9N126, RDH8_BOVIN;  
Q9NYR8, RDH8_HUMAN;  

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