ENZYME entry: EC 1.8.1.5

Accepted Name
2-oxopropyl-CoM reductase (carboxylating).
Alternative Name(s)
2-KPCC.
NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase.
NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase.
Reaction catalysed
2-mercaptoethanesulfonate + acetoacetate + NADP(+) <=> 2-(2-oxopropylthio)ethanesulfonate + CO(2) + NADPH
Comment(s)
  • Also acts on thioethers longer in chain length on the oxo side, e.g. 2-oxobutyl-CoM, but this portion must be attached to CoM (2-mercaptoethanesulfonate); no CoM analogs will substitute.
  • Forms component II of a four-component enzyme system (comprising EC 4.4.1.23 (component I), EC 1.8.1.5 (component II), EC 1.1.1.268 (component III) and EC 1.1.1.269 (component IV)) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
Cross-references
BRENDA1.8.1.5
EC2PDB1.8.1.5
ExplorEnz1.8.1.5
PRIAM enzyme-specific profiles1.8.1.5
KEGG Ligand Database for Enzyme Nomenclature1.8.1.5
IUBMB Enzyme Nomenclature1.8.1.5
IntEnz1.8.1.5
MEDLINEFind literature relating to 1.8.1.5
MetaCyc1.8.1.5
UniProtKB/Swiss-Prot
Q56839, XECC_XANP2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.1.-
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