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ENZYME entry: EC 2.7.1.156

Accepted Name
Adenosylcobinamide kinase.
Alternative Name(s)
Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase.
AdoCbi kinase/AdoCbi-phosphate guanylyltransferase.
Reaction catalysed
ATP or GTP + adenosylcobinamide <=> adenosylcobinamide phosphate + ADP or GDP
Comment(s)
  • In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyze reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl).
  • CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole.
  • The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by CobU.
  • The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalyzed by CobS (EC 2.7.8.26), to yield adenosylcobalamin.
  • CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62) activities.
  • However, both activities are not required at all times.
  • The kinase activity has been proposed to function only when S.typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin.
Cross-references
BRENDA2.7.1.156
EC2PDB2.7.1.156
ExplorEnz2.7.1.156
PRIAM enzyme-specific profiles2.7.1.156
KEGG Ligand Database for Enzyme Nomenclature2.7.1.156
IUBMB Enzyme Nomenclature2.7.1.156
IntEnz2.7.1.156
MEDLINEFind literature relating to 2.7.1.156
MetaCyc2.7.1.156
UniProtKB/Swiss-Prot
Q9I466, COBP_PSEAE;  P29931, COBP_PSEDE;  P0AE77, COBU_ECO57;  
P0AE76, COBU_ECOLI;  Q05599, COBU_SALTY;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-