Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...] View this page in https
ENZYME entry: EC 188.8.131.52
View entry in original ENZYME format
View entry in raw text format (no links)
in this entry
|AdoCbi kinase/AdoCbi-phosphate guanylyltransferase.|
|ATP or GTP + adenosylcobinamide <=> adenosylcobinamide phosphate + ADP or GDP|
- In Salmonella typhimurium LT2, under anaerobic conditions, CobU
(EC 184.108.40.206 and EC 220.127.116.11), CobT (EC 18.104.22.168),
CobC (EC 22.214.171.124) and CobS (EC 126.96.36.199) catalyze reactions in the
nucleotide loop assembly pathway, which convert adenosylcobinamide
(AdoCbi) into adenosylcobalamin (AdoCbl).
- CobT and CobC are involved in 5,6-dimethylbenzimidazole activation
whereby 5,6-dimethylbenzimidazole is converted to its riboside,
- The second branch of the nucleotide loop assembly pathway is the
cobinamide (Cbi) activation branch where AdoCbi or
adenosylcobinamide-phosphate is converted to the activated
intermediate AdoCbi-GDP by CobU.
- The final step in adenosylcobalamin biosynthesis is the condensation
of AdoCbi-GDP with alpha-ribazole, which is catalyzed by CobS
(EC 188.8.131.52), to yield adenosylcobalamin.
- CobU is a bifunctional enzyme that has both kinase (EC 184.108.40.206) and
guanylyltransferase (EC 220.127.116.11) activities.
- However, both activities are not required at all times.
- The kinase activity has been proposed to function only when
S.typhimurium is assimilating cobinamide whereas the
guanylyltransferase activity is required for both assimilation of
exogenous cobinamide and for de novo synthesis of adenosylcobalamin.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
, with possibility to download in different formats, align etc.
entries corresponding to 2.7.1.-
entries corresponding to 2.7.-.-
entries corresponding to 2.-.-.-