ENZYME entry: EC 2.7.8.26

Accepted Name
Adenosylcobinamide-GDP ribazoletransferase.
Alternative Name(s)
Cobalamin (5'-phosphate) synthase.
Cobalamin synthase.
Cobalamin-5'-phosphate synthase.
Reaction catalysed
  • Adenosylcobinamide-GDP + alpha-ribazole <=> GMP + adenosylcobalamin
  • Adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate <=> GMP + adenosylcobalamin 5'-phosphate
Comment(s)
  • In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyze reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl).
  • CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole.
  • The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme CobU.
  • CobS catalyzes the final step in adenosylcobalamin biosynthesis, which is the condensation of AdoCbi-GDP with alpha-ribazole to yield adenosylcobalamin.
Cross-references
BRENDA2.7.8.26
EC2PDB2.7.8.26
ExplorEnz2.7.8.26
PRIAM enzyme-specific profiles2.7.8.26
KEGG Ligand Database for Enzyme Nomenclature2.7.8.26
IUBMB Enzyme Nomenclature2.7.8.26
IntEnz2.7.8.26
MEDLINEFind literature relating to 2.7.8.26
MetaCyc2.7.8.26
UniProtKB/Swiss-Prot
O30198, COBS1_ARCFU;  O27961, COBS2_ARCFU;  B2HZL6, COBS_ACIBC;  
A3M596, COBS_ACIBT;  B9JG16, COBS_AGRRK;  B9JW08, COBS_AGRVS;  
Q0A4T1, COBS_ALKEH;  A6TU75, COBS_ALKMQ;  A8MIW2, COBS_ALKOO;  
Q3M999, COBS_ANAVT;  Q5P2R7, COBS_AROAE;  A8ID91, COBS_AZOC5;  
Q9KCH9, COBS_BACHD;  Q89Q75, COBS_BRADU;  C0Z7H6, COBS_BREBN;  
B2S5A0, COBS_BRUA1;  Q2YNK8, COBS_BRUA2;  Q57DP0, COBS_BRUAB;  
A9MAN9, COBS_BRUC2;  C0RIJ9, COBS_BRUMB;  Q8YGQ8, COBS_BRUME;  
A5VQ44, COBS_BRUO2;  B0CLJ1, COBS_BRUSI;  Q8G156, COBS_BRUSU;  
Q8RCN8, COBS_CALS4;  Q3AE01, COBS_CARHZ;  Q3ARQ6, COBS_CHLCH;  
B3QNS4, COBS_CHLP8;  B3EJP7, COBS_CHLPB;  A4SEC9, COBS_CHLPM;  
Q8KDU6, COBS_CHLTE;  A8AER0, COBS_CITK8;  Q97JA2, COBS_CLOAB;  
A7FS72, COBS_CLOB1;  C3L2A5, COBS_CLOB6;  A6LSW5, COBS_CLOB8;  
B2UXE0, COBS_CLOBA;  B2TPF2, COBS_CLOBB;  A5I013, COBS_CLOBH;  
C1FUP2, COBS_CLOBJ;  B1IGK6, COBS_CLOBK;  A7GBL1, COBS_CLOBL;  
B1KX15, COBS_CLOBM;  B9E675, COBS_CLOK1;  A5N2J8, COBS_CLOK5;  
A0Q0K0, COBS_CLONN;  Q0TRK3, COBS_CLOP1;  Q8XLK5, COBS_CLOPE;  
A9KMP0, COBS_CLOPH;  Q0STX5, COBS_CLOPS;  Q897L5, COBS_CLOTE;  
A3DK68, COBS_CLOTH;  Q6NG92, COBS_CORDI;  Q8FNQ1, COBS_COREF;  
A4QFR6, COBS_CORGB;  Q8NNJ7, COBS_CORGL;  Q9RYR9, COBS_DEIRA;  
Q24VN7, COBS_DESHY;  A4J804, COBS_DESRM;  Q72DL5, COBS_DESVH;  
B8DRQ3, COBS_DESVM;  A1VF70, COBS_DESVV;  A7ZNF6, COBS_ECO24;  
B7UT21, COBS_ECO27;  B7MDB8, COBS_ECO45;  B7L917, COBS_ECO55;  
Q8X8U9, COBS_ECO57;  B5YSS1, COBS_ECO5E;  B7NR82, COBS_ECO7I;  
B7MWP9, COBS_ECO81;  B7M3C8, COBS_ECO8A;  C4ZQQ5, COBS_ECOBW;  
B1X6T0, COBS_ECODH;  A8A1K6, COBS_ECOHS;  Q0TGE0, COBS_ECOL5;  
Q8FGA4, COBS_ECOL6;  B1IZQ8, COBS_ECOLC;  P36561, COBS_ECOLI;  
B7NC26, COBS_ECOLU;  B6I829, COBS_ECOSE;  B1LPV6, COBS_ECOSM;  
A7HMT2, COBS_FERNB;  Q2J8A4, COBS_FRASC;  Q8R666, COBS_FUSNN;  
B9LZU3, COBS_GEODF;  Q5KXP1, COBS_GEOKA;  C5D3K0, COBS_GEOSW;  
A4IQD8, COBS_GEOTN;  B9LRL5, COBS_HALLT;  Q9HPL2, COBS_HALSA;  
Q18KB3, COBS_HALWD;  A9AYY2, COBS_HERA2;  B5XPI1, COBS_KLEP3;  
A6TBB1, COBS_KLEP7;  C5CE71, COBS_KOSOT;  C1D6F9, COBS_LARHH;  
B0SFE6, COBS_LEPBA;  B0SNZ5, COBS_LEPBP;  B1Y854, COBS_LEPCP;  
Q72M34, COBS_LEPIC;  Q8EYK8, COBS_LEPIN;  Q92CQ9, COBS_LISIN;  
C1L254, COBS_LISMC;  Q720T3, COBS_LISMF;  B8DC84, COBS_LISMH;  
Q8Y7X1, COBS_LISMO;  A0AHP2, COBS_LISW6;  Q8TS66, COBS_METAC;  
Q0W1P5, COBS_METAR;  Q465W3, COBS_METBF;  Q12UB0, COBS_METBU;  
Q58833, COBS_METJA;  Q8TUT2, COBS_METKA;  Q8PVB4, COBS_METMA;  
O27184, COBS_METTH;  A0QEZ8, COBS_MYCA1;  Q7VEN6, COBS_MYCBO;  
A1KKQ0, COBS_MYCBP;  C1AQC3, COBS_MYCBT;  A4TBJ8, COBS_MYCGI;  
B2HGX7, COBS_MYCMM;  Q73YK6, COBS_MYCPA;  A0R065, COBS_MYCS2;  
A3Q1R8, COBS_MYCSJ;  A1UIA4, COBS_MYCSK;  Q1B6S1, COBS_MYCSS;  
A5U4N6, COBS_MYCTA;  P9WP90, COBS_MYCTO;  P9WP91, COBS_MYCTU;  
A0PTP3, COBS_MYCUA;  A1TB16, COBS_MYCVP;  A1SJN0, COBS_NOCSJ;  
Q8YZS8, COBS_NOSS1;  Q2GBJ9, COBS_NOVAD;  A6X1H1, COBS_OCHA4;  
B4SH93, COBS_PELPB;  Q180T5, COBS_PEPD6;  Q6L174, COBS_PICTO;  
A1VJY2, COBS_POLNA;  Q12FJ6, COBS_POLSJ;  B4S891, COBS_PROA2;  
A2CCL0, COBS_PROM3;  Q7VDR6, COBS_PROMA;  Q7V4T2, COBS_PROMM;  
Q48FK1, COBS_PSE14;  Q15WS4, COBS_PSEA6;  A6V8S8, COBS_PSEA7;  
Q02JC2, COBS_PSEAB;  Q9I463, COBS_PSEAE;  Q1IDJ5, COBS_PSEE4;  
Q4K8C3, COBS_PSEF5;  C3K0Y6, COBS_PSEFS;  A4XT57, COBS_PSEMY;  
A5W7Q2, COBS_PSEP1;  Q3KFR3, COBS_PSEPF;  B0KT69, COBS_PSEPG;  
Q88M93, COBS_PSEPK;  B1J1P0, COBS_PSEPW;  Q885W4, COBS_PSESM;  
Q4ZQ68, COBS_PSEU2;  A4VJ44, COBS_PSEU5;  Q9V2N1, COBS_PYRAB;  
Q8ZZ89, COBS_PYRAE;  A3MWD7, COBS_PYRCJ;  Q8U400, COBS_PYRFU;  
O58111, COBS_PYRHO;  A1RUA0, COBS_PYRIL;  B2UAJ1, COBS_RALPJ;  
Q8XWS4, COBS_RALSO;  B3PQS4, COBS_RHIE6;  Q2K7G5, COBS_RHIEC;  
Q1MFK3, COBS_RHIL3;  Q98KP0, COBS_RHILO;  B5ZSC5, COBS_RHILW;  
Q92P97, COBS_RHIME;  Q21V77, COBS_RHOFT;  A5V212, COBS_ROSS1;  
A9MLS7, COBS_SALAR;  Q57MY0, COBS_SALCH;  B5FLY5, COBS_SALDC;  
B5QYX4, COBS_SALEP;  B5RBK7, COBS_SALG2;  B4T8W9, COBS_SALHS;  
B4SWC6, COBS_SALNS;  Q5PDU1, COBS_SALPA;  C0Q1Q9, COBS_SALPC;  
B5BG59, COBS_SALPK;  B4TZP6, COBS_SALSV;  Q8Z5N8, COBS_SALTI;  
Q05602, COBS_SALTY;  A1S3L4, COBS_SHEAM;  A3D7X7, COBS_SHEB5;  
A6WJZ2, COBS_SHEB8;  A9L3D9, COBS_SHEB9;  Q12Q70, COBS_SHEDO;  
Q086T5, COBS_SHEFN;  B0TSP8, COBS_SHEHH;  Q8EI17, COBS_SHEON;  
A8H806, COBS_SHEPA;  A4Y9P2, COBS_SHEPC;  B8CJ38, COBS_SHEPW;  
A0L0D2, COBS_SHESA;  Q0HLZ4, COBS_SHESM;  Q0HRU2, COBS_SHESR;  
A1RGP2, COBS_SHESW;  B1KH27, COBS_SHEWM;  B2TWQ9, COBS_SHIB3;  
Q322B3, COBS_SHIBS;  Q32ED1, COBS_SHIDS;  Q0T3C3, COBS_SHIF8;  
Q83R13, COBS_SHIFL;  Q3Z0K3, COBS_SHISS;  A6U9W5, COBS_SINMW;  
Q4JBK2, COBS_SULAC;  C3N0R7, COBS_SULIA;  C4KJU4, COBS_SULIK;  
C3MJX7, COBS_SULIL;  C3MRS8, COBS_SULIM;  C3NMG6, COBS_SULIN;  
C3N903, COBS_SULIY;  Q97TZ6, COBS_SULSO;  Q96Y25, COBS_SULTO;  
Q8GMS2, COBS_SYNE7;  A0LLI5, COBS_SYNFM;  Q5N366, COBS_SYNP6;  
Q55714, COBS_SYNY3;  B7IHD7, COBS_THEAB;  Q9HJ91, COBS_THEAC;  
Q8DJ91, COBS_THEEB;  C5A478, COBS_THEGJ;  Q52454, COBS_THEKO;  
A6LLB7, COBS_THEM4;  B6YV94, COBS_THEON;  B0KCS0, COBS_THEP3;  
B0K2K2, COBS_THEPX;  Q97BG1, COBS_THEVO;  B5YL84, COBS_THEYD;  
Q3SFE7, COBS_THIDA;  Q73K39, COBS_TREDE;  A5F1U5, COBS_VIBC3;  
Q9KSL8, COBS_VIBCH;  C3LLT4, COBS_VIBCM;  Q87Q45, COBS_VIBPA;  
Q8D922, COBS_VIBVU;  Q7MLF2, COBS_VIBVY;  A7IB66, COBS_XANP2;  
P29936, COBV_PSEDE;  

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