ENZYME entry: EC 2.7.1.69

Accepted Name
Protein-N(pi)-phosphohistidine--sugar phosphotransferase.
Alternative Name(s)
Enzyme II of the phosphotransferase system.
PEP--sugar phosphotransferase enzyme II.
PTS permease.
Reaction catalysed
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar <=> protein EIIB + sugar phosphate
Comment(s)
  • Comprises a group of related enzymes.
  • The protein substrate is a phosphocarrier protein of low molecular mass (9.5 kDa).
  • The protein is phosphorylated in a reaction catalyzed by EC 2.7.3.9 and this acts as the phosphate donor for the above reaction.
  • The enzyme translocates the sugar it phosphorylates into bacteria.
  • Aldohexoses and their glycosides and alditols are phosphorylated on O-6; fructose and sorbose on O-1.
  • Glycerone and disaccharides are also substrates.
Cross-references
PROSITEPDOC00795
BRENDA2.7.1.69
EC2PDB2.7.1.69
ExplorEnz2.7.1.69
PRIAM enzyme-specific profiles2.7.1.69
KEGG Ligand Database for Enzyme Nomenclature2.7.1.69
IUBMB Enzyme Nomenclature2.7.1.69
IntEnz2.7.1.69
MEDLINEFind literature relating to 2.7.1.69
MetaCyc2.7.1.69
UniProtKB/Swiss-Prot
P54745, HRSA_ECOLI;  P46321, LICR_BACSU;  O31644, MANR_BACSU;  
P96574, MTLR_BACSU;  P55901, PTEB_AERHY;  O05505, PTEB_BACSU;  
Q45399, PTEB_GEOSE;  P71012, PTF3A_BACSU;  P47308, PTF3A_MYCGE;  
P75039, PTF3A_MYCPN;  P23387, PTF3E_RHOCA;  P69810, PTFB1_ECO57;  
P69809, PTFB1_ECOL6;  P69808, PTFB1_ECOLI;  Q821A9, PTFB1_SHIFL;  
P69818, PTFB2_ECO57;  P69817, PTFB2_ECOL6;  P69816, PTFB2_ECOLI;  
P69819, PTFB2_SHIFL;  P32676, PTFB3_ECOLI;  P20966, PTFBC_ECOLI;  
P44714, PTFBC_HAEIN;  P23355, PTFBC_XANCP;  P26380, PTFB_BACSU;  
P32154, PTFLB_ECOLI;  Q45298, PTG3B_CORGT;  P20166, PTG3C_BACSU;  
P42015, PTG3C_GEOSE;  P47315, PTG3C_MYCGE;  P75569, PTG3C_MYCPN;  
A7WXI2, PTG3C_STAA1;  A6TXX3, PTG3C_STAA2;  Q2FK73, PTG3C_STAA3;  
Q2G1G8, PTG3C_STAA8;  A5IP58, PTG3C_STAA9;  Q2YUZ1, PTG3C_STAAB;  
Q5HJI3, PTG3C_STAAC;  A6QDH3, PTG3C_STAAE;  Q99X32, PTG3C_STAAM;  
Q7A807, PTG3C_STAAN;  Q6GKB7, PTG3C_STAAR;  Q6GCT7, PTG3C_STAAS;  
A8Z0F5, PTG3C_STAAT;  Q8NYM1, PTG3C_STAAW;  Q57071, PTG3C_STACT;  
Q8VRH0, PTG3C_STAEP;  Q5HL73, PTG3C_STAEQ;  Q7CCJ4, PTG3C_STAES;  
Q4L945, PTG3C_STAHJ;  Q4A0C4, PTG3C_STAS1;  P35595, PTG3C_STRPN;  
P57437, PTGCB_BUCAI;  Q8K9J0, PTGCB_BUCAP;  Q89AG6, PTGCB_BUCBP;  
P69788, PTGCB_ECO57;  P69787, PTGCB_ECOL6;  P69786, PTGCB_ECOLI;  
P37439, PTGCB_SALTY;  O32333, PTHB_CLOB8;  P56580, PTHB_ECOLI;  
O32522, PTHB_ERWAM;  P24241, PTIBC_ECOLI;  P46318, PTJB_BACSU;  
P0A436, PTKB_ECO57;  P0A435, PTKB_ECOL6;  P37188, PTKB_ECOLI;  
P0A437, PTKB_SHIFL;  P24400, PTLCB_LACCA;  P23531, PTLCB_LACLL;  
Q5HE15, PTLCB_STAAC;  Q931G6, PTLCB_STAAM;  Q99S77, PTLCB_STAAN;  
Q6GEN9, PTLCB_STAAR;  Q6G7C4, PTLCB_STAAS;  P11162, PTLCB_STAAU;  
Q7A092, PTLCB_STAAW;  Q5HM40, PTLCB_STAEQ;  Q8CNF7, PTLCB_STAES;  
Q4L869, PTLCB_STAHJ;  P50976, PTLCB_STRMU;  P57635, PTM3C_BUCAI;  
Q8K911, PTM3C_BUCAP;  Q89A36, PTM3C_BUCBP;  P00550, PTM3C_ECOLI;  
Q9XBM7, PTM3C_KLEPN;  Q9CLY8, PTM3C_PASMU;  Q9KKQ7, PTM3C_VIBCH;  
Q9K678, PTMCB_BACHD;  P42956, PTMCB_BACSU;  O65989, PTMCB_CLOAB;  
P69827, PTMCB_ECO57;  P69826, PTMCB_ECOLI;  P50852, PTMCB_GEOSE;  
P75146, PTMCB_MYCPN;  Q5HE48, PTMCB_STAAC;  Q99SA3, PTMCB_STAAM;  
Q7A4B3, PTMCB_STAAN;  Q6GES1, PTMCB_STAAR;  Q6G7F6, PTMCB_STAAS;  
Q7A0A4, PTMCB_STAAW;  P28008, PTMCB_STACA;  Q4L9Y1, PTMCB_STAHJ;  
Q49ZA3, PTMCB_STAS1;  Q9KJ75, PTMCB_STRMU;  Q97SH4, PTMCB_STRPN;  
Q8DR34, PTMCB_STRR6;  O31645, PTN3B_BACSU;  Q46072, PTN3B_CORGL;  
P69799, PTNAB_ECO57;  P69798, PTNAB_ECOL6;  P69797, PTNAB_ECOLI;  
P69800, PTNAB_SHIFL;  Q5XAF5, PTNAB_STRP6;  P54715, PTOCB_BACSU;  
P19642, PTOCB_ECOLI;  P42909, PTPB1_ECOLI;  P42904, PTPB2_ECOLI;  
P69830, PTQB_ECO57;  P69796, PTQB_ECOL6;  P69795, PTQB_ECOLI;  
P37081, PTRB_KLEPN;  P43470, PTS3B_PEDPE;  P12655, PTS3B_STRMU;  
P05306, PTSBC_BACSU;  P27219, PTSBC_KLEPN;  Q9CJZ2, PTSBC_PASMU;  
P08470, PTSBC_SALTM;  P51184, PTSBC_STAXY;  P22825, PTSBC_VIBAL;  
Q04938, PTSB_LACLL;  P39794, PTTBC_BACSU;  P36672, PTTBC_ECOLI;  
A7X6P1, PTU3C_STAA1;  A6U4R9, PTU3C_STAA2;  Q2FDW8, PTU3C_STAA3;  
Q2FV87, PTU3C_STAA8;  A5IVW5, PTU3C_STAA9;  Q2YWC1, PTU3C_STAAB;  
Q5HD13, PTU3C_STAAC;  A6QK27, PTU3C_STAAE;  Q99R97, PTU3C_STAAM;  
Q7A3G4, PTU3C_STAAN;  Q6GDR0, PTU3C_STAAR;  Q6G6D6, PTU3C_STAAS;  
A8Z3D6, PTU3C_STAAT;  Q8NUS2, PTU3C_STAAW;  Q53922, PTU3C_STACT;  
O06900, PTUCB_FUSMR;  Q9AGA7, PTUCB_KLEPN;  C7NB69, PTUCB_LEPBD;  
Q9KF90, PTV3B_BACHD;  P40739, PTV3B_BACSU;  P08722, PTV3B_ECOLI;  
P26207, PTV3B_ERWCH;  P39816, PTW3C_BACSU;  P09323, PTW3C_ECOLI;  
P45604, PTW3C_KLEPN;  O34521, PTWCB_BACSU;  Q797S1, PTXBC_BACSU;  
Q2FK70, PTXBC_STAA3;  Q2G1G5, PTXBC_STAA8;  Q2YV12, PTXBC_STAAB;  
Q5HJI0, PTXBC_STAAC;  Q99X29, PTXBC_STAAM;  Q7A804, PTXBC_STAAN;  
Q6GKB4, PTXBC_STAAR;  Q6GCT4, PTXBC_STAAS;  Q7A1Y1, PTXBC_STAAW;  
Q5HLT2, PTXBC_STAEQ;  Q8CNB2, PTXBC_STAES;  Q4L8H5, PTXBC_STAHJ;  
Q49ZN7, PTXBC_STAS1;  P69789, PTXB_ECOLI;  P69790, PTXB_SHIFL;  
Q8XBJ1, PTYBC_ECO57;  Q8FFA9, PTYBC_ECOL6;  P77272, PTYBC_ECOLI;  
Q1R8U3, PTYBC_ECOUT;  Q9CKN5, PTYBC_PASMU;  Q7N9D9, PTYBC_PHOLL;  
Q31Y50, PTYBC_SHIBS;  Q32DC5, PTYBC_SHIDS;  Q83QN3, PTYBC_SHIFL;  
Q9KVD9, PTYBC_VIBCH;  Q5E5T6, PTYBC_VIBF1;  Q87FD5, PTYBC_VIBPA;  
Q8D4Z3, PTYBC_VIBVU;  Q7MBS2, PTYBC_VIBVY;  P15400, SACX_BACSU;  
P58035, SGCB_ECOLI;  P69823, ULAB_ECO57;  Q8FAJ1, ULAB_ECOL6;  
P69822, ULAB_ECOLI;  Q9EXD8, ULAB_MYCPN;  Q57GJ8, ULAB_SALCH;  
Q5PJ47, ULAB_SALPA;  Q8Z171, ULAB_SALTI;  Q8ZK89, ULAB_SALTY;  
Q31TC5, ULAB_SHIBS;  Q328K3, ULAB_SHIDS;  Q83P29, ULAB_SHIFL;  
Q3YUF4, ULAB_SHISS;  Q49397, Y129_MYCGE;  Q9PQW5, Y178_UREPA;  
P75507, Y268_MYCPN;  O51340, Y367_BORBU;  Q5XCC7, Y801_STRP6;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
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