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ENZYME entry: EC 4.1.2.25

Accepted Name
Dihydroneopterin aldolase.
Alternative Name(s)
2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine glycolaldehyde-lyase.
7,8-dihydroneopterin aldolase.
Reaction catalysed
7,8-dihydroneopterin <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
Comment(s)
  • The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis.
  • The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyze the epimerisation of the 2' hydroxy-group (EC 5.1.99.8).
  • The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyzes EC 5.1.99.8 and EC 1.13.11.81.
  • The enzyme from the yeast Saccharomyces cerevisiae also catalyzes the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3 and EC 2.5.1.15.
Cross-references
BRENDA4.1.2.25
EC2PDB4.1.2.25
ExplorEnz4.1.2.25
PRIAM enzyme-specific profiles4.1.2.25
KEGG Ligand Database for Enzyme Nomenclature4.1.2.25
IUBMB Enzyme Nomenclature4.1.2.25
IntEnz4.1.2.25
MEDLINEFind literature relating to 4.1.2.25
MetaCyc4.1.2.25
UniProtKB/Swiss-Prot
Q54YD9, FOL1_DICDI;  P29251, FOL1_PNECA;  Q4LB35, FOL1_SCHPO;  
P53848, FOL1_YEAST;  Q9SF23, FOLB1_ARATH;  Q9FM54, FOLB2_ARATH;  
Q6GKX5, FOLB3_ARATH;  P28823, FOLB_BACSU;  Q9PJC6, FOLB_CHLMU;  
Q9Z7E9, FOLB_CHLPN;  O84620, FOLB_CHLTR;  P0AC17, FOLB_ECOL6;  
P0AC16, FOLB_ECOLI;  P46362, FOLB_HAEIN;  P71513, FOLB_METEA;  
P0A581, FOLB_MYCBO;  O69529, FOLB_MYCLE;  P9WNC4, FOLB_MYCTO;  
P9WNC5, FOLB_MYCTU;  P0AC18, FOLB_SHIFL;  Q5HIG0, FOLB_STAAC;  
P64145, FOLB_STAAM;  P64146, FOLB_STAAN;  Q6GJF6, FOLB_STAAR;  
Q6GBX3, FOLB_STAAS;  P56740, FOLB_STAAU;  P64147, FOLB_STAAW;  
Q5HRN9, FOLB_STAEQ;  Q8CMT8, FOLB_STAES;  Q59920, FOLB_STAHA;  
Q9X8I0, FOLB_STRCO;  P0C0G5, FOLB_STRP1;  P0DB12, FOLB_STRP3;  
Q5XCA7, FOLB_STRP6;  P0A3E2, FOLB_STRP8;  P0DB13, FOLB_STRPQ;  
P0C0G4, FOLB_STRPY;  P74342, FOLB_SYNY3;  Q57851, MPTD_METJA;  
Q8TX89, MPTD_METKA;  Q6L2J9, MPTD_PICTO;  P22291, SULD_STRPN;  
P59657, SULD_STRR6;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
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