ENZYME entry: EC 6.3.5.7

Accepted Name
Glutaminyl-tRNA synthase (glutamine-hydrolyzing).
Alternative Name(s)
Glu-AdT.
Glu-tRNA(Gln) amidotransferase.
Glutamyl-tRNA(Gln) amidotransferase.
Reaction catalysed
ATP + glutamyl-tRNA(Gln) + L-glutamine <=> ADP + phosphate + glutaminyl-tRNA(Gln) + L-glutamate
Comment(s)
  • In systems lacking discernible EC 6.1.1.18, glutaminyl-tRNA(Gln) is formed by a two-enzyme system.
  • In the first step, a nondiscriminating ligase (EC 6.1.1.24) mischarges tRNA(Gln) with glutamate, forming glutamyl-tRNA(Gln).
  • The glutamyl-tRNA(Gln) is not used in protein synthesis until the present enzyme converts it into glutaminyl-tRNA(Gln) (glutamyl- tRNA(Glu) is not a substrate for this reaction).
  • Ammonia or asparagine can substitute for the preferred substrate glutamine.
Cross-references
PROSITEPDOC00948
BRENDA6.3.5.7
EC2PDB6.3.5.7
ExplorEnz6.3.5.7
PRIAM enzyme-specific profiles6.3.5.7
KEGG Ligand Database for Enzyme Nomenclature6.3.5.7
IUBMB Enzyme Nomenclature6.3.5.7
IntEnz6.3.5.7
MEDLINEFind literature relating to 6.3.5.7
MetaCyc6.3.5.7

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-