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ENZYME

ENZYME entry: EC 1.1.1.261

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.261
Accepted Name
sn-glycerol-1-phosphate dehydrogenase
Alternative Name(s)
glycerol-1-phosphate dehydrogenase [NAD(P)(+)]
Gro1PDH
Reaction catalysed
  • sn-glycerol 1-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  • sn-glycerol 1-phosphate + NADP(+) = dihydroxyacetone phosphate + NADPH + H(+)
Comment(s)
  • Responsible for the formation of archaea-specific sn-glycerol-1- phosphate, the first step in the biosynthesis of polar lipids in archaea.
  • It is the enantiomer of sn-glycerol 3-phosphate, the form of glycerophosphate found in bacteria and eukaryotes.
  • The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 2.5.1.41 and EC 2.5.1.42, which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 to form CDP- unsaturated archaeol.
  • The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.
  • Activity of the enzyme is stimulated by K(+).
Cross-references
BRENDA1.1.1.261
EC2PDB1.1.1.261
ExplorEnz1.1.1.261
KEGG Ligand Database for Enzyme Nomenclature1.1.1.261
IUBMB Enzyme Nomenclature1.1.1.261
MEDLINEFind literature relating to 1.1.1.261
MetaCyc1.1.1.261
Rhea expert-curated reactions1.1.1.261
UniProtKB/Swiss-Prot
Q9YER2, G1PDH_AERPEO28599, G1PDH_ARCFUQ65GC3, G1PDH_BACLD
P94527, G1PDH_BACSUA7Z7G4, G1PDH_BACVZA8MC03, G1PDH_CALMQ
A0RXV2, G1PDH_CENSYB3EYN8, G1PDH_GEOSEA4IP94, G1PDH_GEOTN
Q9KBR3, G1PDH_HALH5B9LUA0, G1PDH_HALLTQ5V5G2, G1PDH_HALMA
B0R3A6, G1PDH_HALS3Q9HS49, G1PDH_HALSAQ18JW6, G1PDH_HALWD
A2BN26, G1PDH_HYPBUA8ABP9, G1PDH_IGNH4B1L7K1, G1PDH_KORCO
A6UUD2, G1PDH_META3Q8TJU1, G1PDH_METACQ0W4M8, G1PDH_METAR
A7I9R4, G1PDH_METB6Q46FR7, G1PDH_METBFQ12X59, G1PDH_METBU
Q2FPC7, G1PDH_METHJQ58122, G1PDH_METJAQ8TW08, G1PDH_METKA
A2ST19, G1PDH_METLZA4FZY2, G1PDH_METM5A9A874, G1PDH_METM6
A6VIL2, G1PDH_METM7Q8PZA4, G1PDH_METMAA3CX71, G1PDH_METMJ
Q6M0P4, G1PDH_METMPB8GGP5, G1PDH_METPEA5UJW3, G1PDH_METS3
A4YIZ1, G1PDH_METS5Q2NFL8, G1PDH_METSTP72010, G1PDH_METTH
A0B5P3, G1PDH_METTPA6URL4, G1PDH_METVSQ3ING6, G1PDH_NATPD
A9A2U8, G1PDH_NITMSQ6L0R7, G1PDH_PICTOQ9V0V0, G1PDH_PYRAB
Q8ZWP5, G1PDH_PYRAEA4WLW1, G1PDH_PYRARA3MTM6, G1PDH_PYRCJ
Q8U147, G1PDH_PYRFUO59144, G1PDH_PYRHOA1RV58, G1PDH_PYRIL
B1YCY7, G1PDH_PYRNVC3NHE5, G1PDH_SACI1C3MQ22, G1PDH_SACI2
C3N5P0, G1PDH_SACI3C3MVE1, G1PDH_SACI4C4KHB6, G1PDH_SACI6
C3NEA4, G1PDH_SACI7Q9UXE7, G1PDH_SACS2Q5WL08, G1PDH_SHOC1
A3DN28, G1PDH_STAMFQ4JB01, G1PDH_SULACP58460, G1PDH_SULTO
Q9HJ16, G1PDH_THEACQ5JH91, G1PDH_THEKOA1RZJ9, G1PDH_THEPD
C6A2E4, G1PDH_THESMQ979B1, G1PDH_THEVO

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