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ENZYME

ENZYME entry: EC 2.5.1.42

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.42
Accepted Name
geranylgeranylglycerol-phosphate geranylgeranyltransferase
Alternative Name(s)
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase
DGGGPS
DGGGP synthase
Reaction catalysed
sn-3-O-(geranylgeranyl)glycerol 1-phosphate + (2E,6E,10E)-geranylgeranyl diphosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate
Comment(s)
  • Carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in archaea.
  • 4-Hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and alpha-glycerophosphate cannot act as prenyl-acceptor substrates.
  • The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 1.1.1.261, EC 2.5.1.41, which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 to form CDP-unsaturated archaeol.
  • The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.
Cross-references
BRENDA2.5.1.42
EC2PDB2.5.1.42
ExplorEnz2.5.1.42
KEGG Ligand Database for Enzyme Nomenclature2.5.1.42
IUBMB Enzyme Nomenclature2.5.1.42
MEDLINEFind literature relating to 2.5.1.42
MetaCyc2.5.1.42
Rhea expert-curated reactions2.5.1.42
UniProtKB/Swiss-Prot
O29843, DGGGP_ARCFUB0R3S1, DGGGP_HALS3Q9HRP0, DGGGP_HALSA
Q18J00, DGGGP_HALWDA2BIU7, DGGGP_HYPBUA8A9J7, DGGGP_IGNH4
B1L6Z7, DGGGP_KORCOA6UVU6, DGGGP_META3Q8TS44, DGGGP_METAC
A7I9E7, DGGGP_METB6Q46BD9, DGGGP_METBFQ12VF3, DGGGP_METBU
Q2FN44, DGGGP_METHJQ57727, DGGGP_METJAQ8TWS9, DGGGP_METKA
A2SRL0, DGGGP_METLZA4G0P3, DGGGP_METM5A9A8Y7, DGGGP_METM6
A6VHU1, DGGGP_METM7Q8PV96, DGGGP_METMAA3CW74, DGGGP_METMJ
Q6LWN2, DGGGP_METMPA5ULR8, DGGGP_METS3A4YI21, DGGGP_METS5
Q2NGM1, DGGGP_METSTO27170, DGGGP_METTHA0B8A0, DGGGP_METTP
A6UQV8, DGGGP_METVSQ3INH7, DGGGP_NATPDQ9V2P5, DGGGP_PYRAB
Q8TZM7, DGGGP_PYRFUO57753, DGGGP_PYRHOQ9UWY6, DGGGP_SACS2
Q4J8K2, DGGGP_SULACQ971A3, DGGGP_SULTOC5A1J7, DGGGP_THEGJ
Q5JDN5, DGGGP_THEKOB6YW76, DGGGP_THEONA1S066, DGGGP_THEPD
C6A2C9, DGGGP_THESM

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