| Accepted Name |
|---|
| Geranylgeranylglycerol-phosphate geranylgeranyltransferase.
|
| Alternative Name(s) |
|---|
| (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. |
| DGGGP synthase. |
| DGGGPS. |
| Reaction catalysed |
|---|
| Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate <=> diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate |
| Cofactor(s) |
|---|
| Mg(2+).
|
| Comment(s) |
|---|
- Carries out the second prenyltransfer reaction involved in the
formation of polar membrane lipids in archaea.
- 4-hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and
alpha-glycerophosphate cannot act as prenyl-acceptor substrates.
- The other enzymes involved in the biosynthesis of polar lipids in
archaea are EC 1.1.1.261, EC 2.5.1.41, which, together with this
enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield
unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 to
form CDP-unsaturated archaeol.
- The final step in the pathway involves the addition of L-serine, with
concomitant removal of CMP, leading to the production of unsaturated
archaetidylserine.
|
| Cross-references |
|---|
| BRENDA | 2.5.1.42 |
| EC2PDB | 2.5.1.42 |
| ExplorEnz | 2.5.1.42 |
| PRIAM enzyme-specific profiles | 2.5.1.42 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.42 |
| IUBMB Enzyme Nomenclature | 2.5.1.42 |
| IntEnz | 2.5.1.42 |
| MEDLINE | Find literature relating to 2.5.1.42 |
| MetaCyc | 2.5.1.42 |
| Rhea expert-curated reactions | 2.5.1.42 |
| UniProtKB/Swiss-Prot |
| O29843, DGGGP_ARCFU; | B0R3S1, DGGGP_HALS3; | Q9HRP0, DGGGP_HALSA; |
| Q18J00, DGGGP_HALWD; | A2BIU7, DGGGP_HYPBU; | A8A9J7, DGGGP_IGNH4; |
| B1L6Z7, DGGGP_KORCO; | A6UVU6, DGGGP_META3; | Q8TS44, DGGGP_METAC; |
| A7I9E7, DGGGP_METB6; | Q46BD9, DGGGP_METBF; | Q12VF3, DGGGP_METBU; |
| Q2FN44, DGGGP_METHJ; | Q57727, DGGGP_METJA; | Q8TWS9, DGGGP_METKA; |
| A2SRL0, DGGGP_METLZ; | A4G0P3, DGGGP_METM5; | A9A8Y7, DGGGP_METM6; |
| A6VHU1, DGGGP_METM7; | Q8PV96, DGGGP_METMA; | A3CW74, DGGGP_METMJ; |
| Q6LWN2, DGGGP_METMP; | A5ULR8, DGGGP_METS3; | A4YI21, DGGGP_METS5; |
| Q2NGM1, DGGGP_METST; | O27170, DGGGP_METTH; | A0B8A0, DGGGP_METTP; |
| A6UQV8, DGGGP_METVS; | Q3INH7, DGGGP_NATPD; | Q9V2P5, DGGGP_PYRAB; |
| Q8TZM7, DGGGP_PYRFU; | O57753, DGGGP_PYRHO; | Q9UWY6, DGGGP_SACS2; |
| Q4J8K2, DGGGP_SULAC; | Q971A3, DGGGP_SULTO; | C5A1J7, DGGGP_THEGJ; |
| Q5JDN5, DGGGP_THEKO; | B6YW76, DGGGP_THEON; | A1S066, DGGGP_THEPD; |
| C6A2C9, DGGGP_THESM; |
|