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ENZYME entry: EC 2.5.1.41

Accepted Name
Phosphoglycerol geranylgeranyltransferase.
Alternative Name(s)
(S)-3-O-geranylgeranylglyceryl phosphate synthase.
GGGP synthase.
GGGPS.
Reaction catalysed
Geranylgeranyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • Catalyzes the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria.
  • It catalyzes the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate.
  • The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 1.1.1.261, EC 2.5.1.42 and EC 2.7.7.67, which lead to the formation of CDP-unsaturated archaeol.
  • The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.
Cross-references
BRENDA2.5.1.41
EC2PDB2.5.1.41
ExplorEnz2.5.1.41
PRIAM enzyme-specific profiles2.5.1.41
KEGG Ligand Database for Enzyme Nomenclature2.5.1.41
IUBMB Enzyme Nomenclature2.5.1.41
IntEnz2.5.1.41
MEDLINEFind literature relating to 2.5.1.41
MetaCyc2.5.1.41
Rhea expert-curated reactions2.5.1.41
UniProtKB/Swiss-Prot
Q9YEF5, GGGPS_AERPE;  O29844, GGGPS_ARCFU;  A8MDA4, GGGPS_CALMQ;  
A0RYM1, GGGPS_CENSY;  C7PEQ0, GGGPS_CHIPD;  A5FJK8, GGGPS_FLAJ1;  
Q5V1N9, GGGPS_HALMA;  B0R2Z3, GGGPS_HALS3;  Q9HSF8, GGGPS_HALSA;  
Q18KP6, GGGPS_HALWD;  A2BIS8, GGGPS_HYPBU;  A8A9K6, GGGPS_IGNH4;  
B1L6Q8, GGGPS_KORCO;  A6UW70, GGGPS_META3;  Q8TJ20, GGGPS_METAC;  
Q0W6K5, GGGPS_METAR;  A7I6L7, GGGPS_METB6;  Q46EN8, GGGPS_METBF;  
Q12VH4, GGGPS_METBU;  Q2FQM4, GGGPS_METHJ;  Q58647, GGGPS_METJA;  
Q8TXM0, GGGPS_METKA;  A2SSK1, GGGPS_METLZ;  A4G0J0, GGGPS_METM5;  
A9A8T4, GGGPS_METM6;  A6VHZ5, GGGPS_METM7;  Q8PYC0, GGGPS_METMA;  
A3CTK2, GGGPS_METMJ;  Q6M1A9, GGGPS_METMP;  B8GHM9, GGGPS_METPE;  
A5UJF1, GGGPS_METS3;  A4YJ26, GGGPS_METS5;  Q2NET5, GGGPS_METST;  
O26652, GGGPS_METTH;  P0C882, GGGPS_METTM;  A0B8J3, GGGPS_METTP;  
A6URI9, GGGPS_METVS;  Q3IT31, GGGPS_NATPD;  A9A3Z1, GGGPS_NITMS;  
Q6L2N4, GGGPS_PICTO;  Q9UZN7, GGGPS_PYRAB;  Q8ZTX5, GGGPS_PYRAE;  
A4WLS7, GGGPS_PYRAR;  A3MUU3, GGGPS_PYRCJ;  Q8U213, GGGPS_PYRFU;  
O58851, GGGPS_PYRHO;  A1RRN9, GGGPS_PYRIL;  B1YAF0, GGGPS_PYRNV;  
Q980N1, GGGPS_SACS2;  D2QS27, GGGPS_SPILD;  A3DN81, GGGPS_STAMF;  
Q4JAS3, GGGPS_SULAC;  C3MZJ5, GGGPS_SULIA;  C4KIS5, GGGPS_SULIK;  
C3MRH0, GGGPS_SULIL;  C3MY66, GGGPS_SULIM;  C3NFV6, GGGPS_SULIN;  
C3N7L7, GGGPS_SULIY;  Q975W8, GGGPS_SULTO;  Q9HJH3, GGGPS_THEAC;  
C5A615, GGGPS_THEGJ;  Q5JDY1, GGGPS_THEKO;  A1RXV6, GGGPS_THEPD;  
C6A2A3, GGGPS_THESM;  Q97AR4, GGGPS_THEVO;  D5BCE4, GGGPS_ZUNPS;  

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