Expasy logo

ENZYME

ENZYME entry: EC 2.5.1.41

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.41
Accepted Name
phosphoglycerol geranylgeranyltransferase
Alternative Name(s)
(S)-3-O-geranylgeranylglyceryl phosphate synthase
GGGPS
GGGP synthase
Reaction catalysed
sn-glycerol 1-phosphate + (2E,6E,10E)-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate
Comment(s)
  • Catalyzes the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria.
  • It catalyzes the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate.
  • The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 1.1.1.261, EC 2.5.1.42 and EC 2.7.7.67, which lead to the formation of CDP-unsaturated archaeol.
  • The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.
Cross-references
BRENDA2.5.1.41
EC2PDB2.5.1.41
ExplorEnz2.5.1.41
KEGG Ligand Database for Enzyme Nomenclature2.5.1.41
IUBMB Enzyme Nomenclature2.5.1.41
MEDLINEFind literature relating to 2.5.1.41
MetaCyc2.5.1.41
Rhea expert-curated reactions2.5.1.41
UniProtKB/Swiss-Prot
Q9YEF5, GGGPS_AERPEO29844, GGGPS_ARCFUA8MDA4, GGGPS_CALMQ
A0RYM1, GGGPS_CENSYC7PEQ0, GGGPS_CHIPDA5FJK8, GGGPS_FLAJ1
Q5V1N9, GGGPS_HALMAB0R2Z3, GGGPS_HALS3Q9HSF8, GGGPS_HALSA
Q18KP6, GGGPS_HALWDA2BIS8, GGGPS_HYPBUA8A9K6, GGGPS_IGNH4
B1L6Q8, GGGPS_KORCOA6UW70, GGGPS_META3Q8TJ20, GGGPS_METAC
Q0W6K5, GGGPS_METARA7I6L7, GGGPS_METB6Q46EN8, GGGPS_METBF
Q12VH4, GGGPS_METBUQ2FQM4, GGGPS_METHJQ58647, GGGPS_METJA
Q8TXM0, GGGPS_METKAA2SSK1, GGGPS_METLZA4G0J0, GGGPS_METM5
A9A8T4, GGGPS_METM6A6VHZ5, GGGPS_METM7Q8PYC0, GGGPS_METMA
A3CTK2, GGGPS_METMJQ6M1A9, GGGPS_METMPB8GHM9, GGGPS_METPE
A5UJF1, GGGPS_METS3A4YJ26, GGGPS_METS5Q2NET5, GGGPS_METST
O26652, GGGPS_METTHP0C882, GGGPS_METTMA0B8J3, GGGPS_METTP
A6URI9, GGGPS_METVSQ3IT31, GGGPS_NATPDA9A3Z1, GGGPS_NITMS
Q6L2N4, GGGPS_PICTOQ9UZN7, GGGPS_PYRABQ8ZTX5, GGGPS_PYRAE
A4WLS7, GGGPS_PYRARA3MUU3, GGGPS_PYRCJQ8U213, GGGPS_PYRFU
O58851, GGGPS_PYRHOA1RRN9, GGGPS_PYRILB1YAF0, GGGPS_PYRNV
C3NFV6, GGGPS_SACI1C3MRH0, GGGPS_SACI2C3MZJ5, GGGPS_SACI3
C3MY66, GGGPS_SACI4C4KIS5, GGGPS_SACI6C3N7L7, GGGPS_SACI7
Q980N1, GGGPS_SACS2D2QS27, GGGPS_SPILDA3DN81, GGGPS_STAMF
Q4JAS3, GGGPS_SULACQ975W8, GGGPS_SULTOQ9HJH3, GGGPS_THEAC
C5A615, GGGPS_THEGJQ5JDY1, GGGPS_THEKOA1RXV6, GGGPS_THEPD
C6A2A3, GGGPS_THESMQ97AR4, GGGPS_THEVOD5BCE4, GGGPS_ZUNPS

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-