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ENZYME entry: EC 1.1.1.269

Accepted Name
2-(S)-hydroxypropyl-CoM dehydrogenase.
Alternative Name(s)
2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase.
Reaction catalysed
(2S)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH
Comment(s)
  • Highly specific for (S)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.268, which is highly specific for the (R)-enantiomer.
  • Forms component IV of a four-component enzyme system (comprising EC 4.4.1.23 (component I), EC 1.8.1.5 (component II), EC 1.1.1.268 (component III) and EC 1.1.1.269 (component IV)) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
Cross-references
BRENDA1.1.1.269
EC2PDB1.1.1.269
ExplorEnz1.1.1.269
PRIAM enzyme-specific profiles1.1.1.269
KEGG Ligand Database for Enzyme Nomenclature1.1.1.269
IUBMB Enzyme Nomenclature1.1.1.269
IntEnz1.1.1.269
MEDLINEFind literature relating to 1.1.1.269
MetaCyc1.1.1.269
Rhea expert-curated reactions1.1.1.269
UniProtKB/Swiss-Prot
Q56841, HCDS1_XANP2;  A7IQH5, HCDS3_XANP2;  

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