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ENZYME entry: EC 4.4.1.23

Accepted Name
2-hydroxypropyl-CoM lyase.
Alternative Name(s)
Coenzyme M-epoxyalkane ligase.
EaCoMT.
Reaction catalysed
  • (R)-2-hydroxypropyl-CoM <=> (R)-1,2-epoxypropane + HS-CoM
  • (S)-2-hydroxypropyl-CoM <=> (S)-1,2-epoxypropane + HS-CoM
Cofactor(s)
Zn(2+).
Comment(s)
  • Acts on both enantiomers of chiral epoxyalkanes to form the corresponding (R)- and (S)-2-hydroxyalkyl-CoM adducts.
  • The enzyme will function with some other thiols (e.g., 2-sulfanylethanol) as the nucleophile.
  • Uses short-chain epoxyalkanes from C(2) (epoxyethane) to C(6) (1,2- epoxyhexane).
  • This enzyme forms component I of a four-component enzyme system (comprising EC 4.4.1.23 (component I), EC 1.8.1.5 (component II), EC 1.1.1.268 (component III) and EC 1.1.1.269 (component IV)) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
  • Formerly EC 4.2.99.19.
Cross-references
BRENDA4.4.1.23
EC2PDB4.4.1.23
ExplorEnz4.4.1.23
PRIAM enzyme-specific profiles4.4.1.23
KEGG Ligand Database for Enzyme Nomenclature4.4.1.23
IUBMB Enzyme Nomenclature4.4.1.23
IntEnz4.4.1.23
MEDLINEFind literature relating to 4.4.1.23
MetaCyc4.4.1.23
Rhea expert-curated reactions4.4.1.23
UniProtKB/Swiss-Prot
Q56837, XECA_XANP2

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