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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
2-oxopropyl-CoM reductase (carboxylating).
Alternative Name(s)
NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase.
NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase.
Reaction catalysed
2-mercaptoethanesulfonate + acetoacetate + NADP(+) <=> 2-(2-oxopropylthio)ethanesulfonate + CO(2) + NADPH
  • Also acts on thioethers longer in chain length on the oxo side, e.g. 2-oxobutyl-CoM, but this portion must be attached to CoM (2-mercaptoethanesulfonate); no CoM analogs will substitute.
  • Forms component II of a four-component enzyme system (comprising EC (component I), EC (component II), EC (component III) and EC (component IV)) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
PRIAM enzyme-specific profiles1.8.1.5
KEGG Ligand Database for Enzyme Nomenclature1.8.1.5
IUBMB Enzyme Nomenclature1.8.1.5
MEDLINEFind literature relating to
Q56839, XECC_XANP2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.1.-
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