ENZYME entry: EC 1.1.1.286
Accepted Name |
isocitrate--homoisocitrate dehydrogenase.
|
Alternative Name(s) |
homoisocitrate--isocitrate dehydrogenase. |
Reaction catalysed |
- D-threo-isocitrate + NAD(+) <=> 2-oxoglutarate + CO2 + NADH
- (2R,3S)-homoisocitrate + NAD(+) <=> 2-oxoadipate + CO2 + NADH
|
Comment(s) |
- Unlike EC 1.1.1.41 and EC 1.1.1.87, this enzyme, from Pyrococcus
horikoshii, can use both isocitrate and homoisocitrate as substrate.
- May play a role in both the lysine and glutamate biosynthesis
pathways.
|
Cross-references |
BRENDA | 1.1.1.286 |
EC2PDB | 1.1.1.286 |
ExplorEnz | 1.1.1.286 |
PRIAM enzyme-specific profiles | 1.1.1.286 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.286 |
IUBMB Enzyme Nomenclature | 1.1.1.286 |
IntEnz | 1.1.1.286 |
MEDLINE | Find literature relating to 1.1.1.286 |
MetaCyc | 1.1.1.286 |
Rhea expert-curated reactions | 1.1.1.286 |
UniProtKB/Swiss-Prot |
|
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