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ENZYME entry: EC 1.1.1.286

Accepted Name
Isocitrate--homoisocitrate dehydrogenase.
Alternative Name(s)
Homoisocitrate--isocitrate dehydrogenase.
Reaction catalysed
  • Isocitrate + NAD(+) <=> 2-oxoglutarate + CO(2) + NADH
  • (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) <=> 2-oxoadipate + CO(2) + NADH
Cofactor(s)
Mn(2+); NH(4)(+) or K(+).
Comment(s)
  • Unlike EC 1.1.1.41 and EC 1.1.1.87, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrate.
  • May play a role in both the lysine and glutamate biosynthesis pathways.
Cross-references
PROSITEPDOC00389
BRENDA1.1.1.286
EC2PDB1.1.1.286
ExplorEnz1.1.1.286
PRIAM enzyme-specific profiles1.1.1.286
KEGG Ligand Database for Enzyme Nomenclature1.1.1.286
IUBMB Enzyme Nomenclature1.1.1.286
IntEnz1.1.1.286
MEDLINEFind literature relating to 1.1.1.286
MetaCyc1.1.1.286
Rhea expert-curated reactions1.1.1.286
UniProtKB/Swiss-Prot
O59394, HICDH_PYRHO;  Q72IW9, HICDH_THET2;  Q5SIJ1, HICDH_THET8;  

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