ENZYME entry: EC 1.1.1.286
| Accepted Name |
|---|
| Isocitrate--homoisocitrate dehydrogenase.
|
| Alternative Name(s) |
|---|
| Homoisocitrate--isocitrate dehydrogenase. |
| Reaction catalysed |
|---|
- Isocitrate + NAD(+) <=> 2-oxoglutarate + CO(2) + NADH
- (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) <=> 2-oxoadipate + CO(2) + NADH
|
| Cofactor(s) |
|---|
| Mn(2+); NH(4)(+) or K(+).
|
| Comment(s) |
|---|
- Unlike EC 1.1.1.41 and EC 1.1.1.87, this enzyme, from Pyrococcus
horikoshii, can use both isocitrate and homoisocitrate as substrate.
- May play a role in both the lysine and glutamate biosynthesis
pathways.
|
| Cross-references |
|---|
| PROSITE | PDOC00389 |
| BRENDA | 1.1.1.286 |
| EC2PDB | 1.1.1.286 |
| ExplorEnz | 1.1.1.286 |
| PRIAM enzyme-specific profiles | 1.1.1.286 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.286 |
| IUBMB Enzyme Nomenclature | 1.1.1.286 |
| IntEnz | 1.1.1.286 |
| MEDLINE | Find literature relating to 1.1.1.286 |
| MetaCyc | 1.1.1.286 |
| UniProtKB/Swiss-Prot |
|
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