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ENZYME

ENZYME entry: EC 1.1.1.330

Accepted Name
very-long-chain 3-oxoacyl-CoA reductase
Alternative Name(s)
very-long-chain 3-ketoacyl-CoA reductase
very-long-chain beta-ketoacyl-CoA reductase
Reaction catalysed
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH
Comment(s)
  • The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.
  • The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, EC 4.2.1.134 and EC 1.3.1.93.
  • Formerly EC 1.1.1.n13 and EC 2.3.1.119.
Cross-references
BRENDA1.1.1.330
EC2PDB1.1.1.330
ExplorEnz1.1.1.330
PRIAM enzyme-specific profiles1.1.1.330
KEGG Ligand Database for Enzyme Nomenclature1.1.1.330
IUBMB Enzyme Nomenclature1.1.1.330
IntEnz1.1.1.330
MEDLINEFind literature relating to 1.1.1.330
MetaCyc1.1.1.330
Rhea expert-curated reactions1.1.1.330
UniProtKB/Swiss-Prot
Q6P3L6, DH12A_DANREQ5XG41, DH12A_XENLAQ6QA33, DH12B_DANRE
Q8AVY8, DH12B_XENLAO57314, DHB12_ANAPLQ5E9H7, DHB12_BOVIN
Q53GQ0, DHB12_HUMANQ4R5G7, DHB12_MACFAO70503, DHB12_MOUSE
Q6P7R8, DHB12_RATQ28IU1, DHB12_XENTRQ8L9C4, KCR1_ARATH
Q60V51, LE767_CAEBRQ09517, LE767_CAEELA6RBW9, MKAR_AJECN
Q75A60, MKAR_ASHGOA1C6J8, MKAR_ASPCLB0XSI3, MKAR_ASPFC
Q4X117, MKAR_ASPFUA2QCH3, MKAR_ASPNCQ2UET3, MKAR_ASPOR
Q0CY11, MKAR_ASPTNA6SG70, MKAR_BOTFBQ59V93, MKAR_CANAL
Q6FRM0, MKAR_CANGBQ2H1V7, MKAR_CHAGBQ1DNC5, MKAR_COCIM
A8N6B4, MKAR_COPC7P0CR35, MKAR_CRYNBP0CR34, MKAR_CRYNJ
Q6BIG0, MKAR_DEBHAQ5B0R9, MKAR_EMENIQ6CVS4, MKAR_KLULC
B0D8R3, MKAR_LACBSA5E0R1, MKAR_LODELA4QTE3, MKAR_MAGO7
A8Q1U2, MKAR_MALGOA1DH66, MKAR_NEOFIQ7RYE5, MKAR_NEUCR
Q0U3N7, MKAR_PHANOA5DND6, MKAR_PICGUA3LXZ3, MKAR_PICST
B2B3L4, MKAR_PODANB2WMJ3, MKAR_PYRTRQ10245, MKAR_SCHPO
A7F8T1, MKAR_SCLS1Q4P622, MKAR_USTMAA7TMJ2, MKAR_VANPO
Q6CHP1, MKAR_YARLIB3LN00, MKAR_YEAS1A6ZLA1, MKAR_YEAS7
P38286, MKAR_YEAST

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