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ENZYME entry: EC 1.1.1.330

Accepted Name
very-long-chain 3-oxoacyl-CoA reductase.
Alternative Name(s)
very-long-chain 3-ketoacyl-CoA reductase.
very-long-chain beta-ketoacyl-CoA reductase.
Reaction catalysed
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH
Comment(s)
  • The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.
  • The enzyme is active with substrates with chain length of C16 to C34, depending on the species.
  • Cf. EC 2.3.1.199, EC 4.2.1.134 and EC 1.3.1.93.
  • Formerly EC 1.1.1.n13 and EC 2.3.1.119.
Cross-references
BRENDA1.1.1.330
EC2PDB1.1.1.330
ExplorEnz1.1.1.330
PRIAM enzyme-specific profiles1.1.1.330
KEGG Ligand Database for Enzyme Nomenclature1.1.1.330
IUBMB Enzyme Nomenclature1.1.1.330
IntEnz1.1.1.330
MEDLINEFind literature relating to 1.1.1.330
MetaCyc1.1.1.330
Rhea expert-curated reactions1.1.1.330
UniProtKB/Swiss-Prot
Q6P3L6, DH12A_DANRE;  Q5XG41, DH12A_XENLA;  Q6QA33, DH12B_DANRE;  
Q8AVY8, DH12B_XENLA;  O57314, DHB12_ANAPL;  Q5E9H7, DHB12_BOVIN;  
Q53GQ0, DHB12_HUMAN;  Q4R5G7, DHB12_MACFA;  O70503, DHB12_MOUSE;  
Q6P7R8, DHB12_RAT;  Q28IU1, DHB12_XENTR;  Q8L9C4, KCR1_ARATH;  
Q60V51, LE767_CAEBR;  Q09517, LE767_CAEEL;  A6RBW9, MKAR_AJECN;  
Q75A60, MKAR_ASHGO;  A1C6J8, MKAR_ASPCL;  B0XSI3, MKAR_ASPFC;  
Q4X117, MKAR_ASPFU;  A2QCH3, MKAR_ASPNC;  Q2UET3, MKAR_ASPOR;  
Q0CY11, MKAR_ASPTN;  A6SG70, MKAR_BOTFB;  Q59V93, MKAR_CANAL;  
Q6FRM0, MKAR_CANGA;  Q2H1V7, MKAR_CHAGB;  Q1DNC5, MKAR_COCIM;  
A8N6B4, MKAR_COPC7;  P0CR35, MKAR_CRYNB;  P0CR34, MKAR_CRYNJ;  
Q6BIG0, MKAR_DEBHA;  Q5B0R9, MKAR_EMENI;  Q6CVS4, MKAR_KLULA;  
B0D8R3, MKAR_LACBS;  A5E0R1, MKAR_LODEL;  A4QTE3, MKAR_MAGO7;  
A8Q1U2, MKAR_MALGO;  A1DH66, MKAR_NEOFI;  Q7RYE5, MKAR_NEUCR;  
Q0U3N7, MKAR_PHANO;  A5DND6, MKAR_PICGU;  A3LXZ3, MKAR_PICST;  
B2B3L4, MKAR_PODAN;  B2WMJ3, MKAR_PYRTR;  Q10245, MKAR_SCHPO;  
A7F8T1, MKAR_SCLS1;  Q4P622, MKAR_USTMA;  A7TMJ2, MKAR_VANPO;  
Q6CHP1, MKAR_YARLI;  B3LN00, MKAR_YEAS1;  A6ZLA1, MKAR_YEAS7;  
P38286, MKAR_YEAST;  

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