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ENZYME entry: EC 2.3.1.199

Accepted Name
very-long-chain 3-oxoacyl-CoA synthase.
Alternative Name(s)
condensing enzyme.
very-long-chain 3-ketoacyl-CoA synthase.
very-long-chain beta-ketoacyl-CoA synthase.
Reaction catalysed
a very-long-chain acyl-CoA + H(+) + malonyl-CoA <=> a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
Comment(s)
  • This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.
  • Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids.
  • For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate, while CER6 from the same plant prefers substrates with chain length of C22 to C32.
  • Cf. EC 1.1.1.330, EC 4.2.1.134 and EC 1.3.1.93.
  • Formerly EC 2.3.1.119 and EC 2.3.1.n8.
Cross-references
BRENDA2.3.1.199
EC2PDB2.3.1.199
ExplorEnz2.3.1.199
PRIAM enzyme-specific profiles2.3.1.199
KEGG Ligand Database for Enzyme Nomenclature2.3.1.199
IUBMB Enzyme Nomenclature2.3.1.199
IntEnz2.3.1.199
MEDLINEFind literature relating to 2.3.1.199
MetaCyc2.3.1.199
Rhea expert-curated reactions2.3.1.199
UniProtKB/Swiss-Prot
P39540, ELO1_YEAST;  P25358, ELO2_YEAST;  P49191, ELO3_CAEEL;  
P40319, ELO3_YEAST;  Q03574, ELO4_CAEEL;  Q54CJ4, ELOA_DICDI;  
Q9VH58, ELOF_DROME;  B4QVX4, ELOF_DROSI;  Q9UTF7, ELOH1_SCHPO;  
Q7LKX0, ELOH2_SCHPO;  Q9BW60, ELOV1_HUMAN;  Q9JLJ5, ELOV1_MOUSE;  
Q9NXB9, ELOV2_HUMAN;  Q9JLJ4, ELOV2_MOUSE;  D4A612, ELOV2_RAT;  
Q9HB03, ELOV3_HUMAN;  O35949, ELOV3_MOUSE;  Q9GZR5, ELOV4_HUMAN;  
Q95K73, ELOV4_MACFA;  Q3S8M4, ELOV4_MACMU;  Q9EQC4, ELOV4_MOUSE;  
Q2KJD9, ELOV5_BOVIN;  Q9NYP7, ELOV5_HUMAN;  Q4R516, ELOV5_MACFA;  
Q8BHI7, ELOV5_MOUSE;  Q5RFL5, ELOV5_PONAB;  Q920L7, ELOV5_RAT;  
A0A0C5PHQ7, ELOV5_TACFU;  Q32NI8, ELOV5_XENLA;  Q5M8U1, ELOV5_XENTR;  
Q5ZJR8, ELOV6_CHICK;  Q6PC64, ELOV6_DANRE;  Q9VV87, ELOV6_DROME;  
Q9H5J4, ELOV6_HUMAN;  Q920L5, ELOV6_MOUSE;  Q920L6, ELOV6_RAT;  
A0JNC4, ELOV7_BOVIN;  A1L3X0, ELOV7_HUMAN;  Q9D2Y9, ELOV7_MOUSE;  
D4ADY9, ELOV7_RAT;  Q9VHX7, ELOVL_DROME;  Q1HRV8, ELVL1_AEDAE;  
Q570B4, KCS10_ARATH;  O48780, KCS11_ARATH;  Q9SIB2, KCS12_ARATH;  
Q9ZUZ0, KCS13_ARATH;  Q9SS39, KCS14_ARATH;  Q9SUY9, KCS15_ARATH;  
Q9SYZ0, KCS16_ARATH;  O65677, KCS17_ARATH;  Q38860, KCS18_ARATH;  
Q9LZ72, KCS19_ARATH;  Q9MAM3, KCS1_ARATH;  Q9FG87, KCS20_ARATH;  
Q7XEM4, KCS20_ORYSJ;  Q9FH27, KCS21_ARATH;  Q5XEP9, KCS2_ARATH;  
Q9LQP8, KCS3_ARATH;  Q9LN49, KCS4_ARATH;  Q9C6L5, KCS5_ARATH;  
Q9XF43, KCS6_ARATH;  Q9C992, KCS7_ARATH;  Q4V3C9, KCS8_ARATH;  
Q9SIX1, KCS9_ARATH;  Q54TC9, SRE1_DICDI;  Q86JM5, Y2012_DICDI;  
Q555E8, Y4669_DICDI;  

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