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ENZYME

ENZYME entry: EC 2.3.1.199

Accepted Name
very-long-chain 3-oxoacyl-CoA synthase
Alternative Name(s)
condensing enzyme
very-long-chain 3-ketoacyl-CoA synthase
very-long-chain beta-ketoacyl-CoA synthase
Reaction catalysed
a very-long-chain acyl-CoA + H(+) + malonyl-CoA <=> a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
Comment(s)
  • This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.
  • Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids.
  • For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate, while CER6 from the same plant prefers substrates with chain length of C22 to C32. cf. EC 1.1.1.330, EC 1.3.1.93 and EC 4.2.1.134.
  • Formerly EC 2.3.1.119 and EC 2.3.1.n8.
Cross-references
BRENDA2.3.1.199
EC2PDB2.3.1.199
ExplorEnz2.3.1.199
PRIAM enzyme-specific profiles2.3.1.199
KEGG Ligand Database for Enzyme Nomenclature2.3.1.199
IUBMB Enzyme Nomenclature2.3.1.199
IntEnz2.3.1.199
MEDLINEFind literature relating to 2.3.1.199
MetaCyc2.3.1.199
Rhea expert-curated reactions2.3.1.199
UniProtKB/Swiss-Prot
P39540, ELO1_YEASTP25358, ELO2_YEASTP49191, ELO3_CAEEL
P40319, ELO3_YEASTQ03574, ELO4_CAEELQ54CJ4, ELOA_DICDI
Q9VH58, ELOF_DROMEB4QVX4, ELOF_DROSIQ9UTF7, ELOH1_SCHPO
Q7LKX0, ELOH2_SCHPOQ9BW60, ELOV1_HUMANQ9JLJ5, ELOV1_MOUSE
Q9NXB9, ELOV2_HUMANQ9JLJ4, ELOV2_MOUSED4A612, ELOV2_RAT
Q9HB03, ELOV3_HUMANO35949, ELOV3_MOUSEQ9GZR5, ELOV4_HUMAN
Q95K73, ELOV4_MACFAQ3S8M4, ELOV4_MACMUQ9EQC4, ELOV4_MOUSE
Q2KJD9, ELOV5_BOVINQ9NYP7, ELOV5_HUMANQ4R516, ELOV5_MACFA
Q8BHI7, ELOV5_MOUSEQ5RFL5, ELOV5_PONABQ920L7, ELOV5_RAT
A0A0C5PHQ7, ELOV5_TACFUQ32NI8, ELOV5_XENLAQ5M8U1, ELOV5_XENTR
Q5ZJR8, ELOV6_CHICKQ6PC64, ELOV6_DANREQ9VV87, ELOV6_DROME
Q9H5J4, ELOV6_HUMANQ920L5, ELOV6_MOUSEQ920L6, ELOV6_RAT
A0JNC4, ELOV7_BOVINQ9VHX7, ELOV7_DROMEA1L3X0, ELOV7_HUMAN
Q9D2Y9, ELOV7_MOUSED4ADY9, ELOV7_RATQ1HRV8, ELVL1_AEDAE
Q570B4, KCS10_ARATHO48780, KCS11_ARATHQ9SIB2, KCS12_ARATH
Q9ZUZ0, KCS13_ARATHQ9SS39, KCS14_ARATHQ9SUY9, KCS15_ARATH
Q9SYZ0, KCS16_ARATHO65677, KCS17_ARATHQ38860, KCS18_ARATH
Q9LZ72, KCS19_ARATHQ9MAM3, KCS1_ARATHQ9FG87, KCS20_ARATH
Q7XEM4, KCS20_ORYSJQ9FH27, KCS21_ARATHQ5XEP9, KCS2_ARATH
Q9LQP8, KCS3_ARATHQ9LN49, KCS4_ARATHQ9C6L5, KCS5_ARATH
Q9XF43, KCS6_ARATHQ9C992, KCS7_ARATHQ4V3C9, KCS8_ARATH
Q9SIX1, KCS9_ARATHQ54TC9, SRE1_DICDIQ86JM5, Y2012_DICDI
Q555E8, Y4669_DICDI

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