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ENZYME

ENZYME entry: EC 2.3.1.199

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.199
Accepted Name
very-long-chain 3-oxoacyl-CoA synthase
Alternative Name(s)
condensing enzyme
very-long-chain 3-ketoacyl-CoA synthase
very-long-chain beta-ketoacyl-CoA synthase
Reaction catalysed
a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
Comment(s)
  • This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.
  • Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids.
  • For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate, while CER6 from the same plant prefers substrates with chain length of C22 to C32. cf. EC 1.1.1.330, EC 1.3.1.93 and EC 4.2.1.134.
  • Formerly EC 2.3.1.119 and EC 2.3.1.n8.
Cross-references
BRENDA2.3.1.199
EC2PDB2.3.1.199
ExplorEnz2.3.1.199
KEGG Ligand Database for Enzyme Nomenclature2.3.1.199
IUBMB Enzyme Nomenclature2.3.1.199
MEDLINEFind literature relating to 2.3.1.199
MetaCyc2.3.1.199
Rhea expert-curated reactions2.3.1.199
UniProtKB/Swiss-Prot
P39540, ELO1_YEASTP25358, ELO2_YEASTP49191, ELO3_CAEEL
P40319, ELO3_YEASTQ4D5J7, ELO4A_TRYCCQ4DUK4, ELO4B_TRYCC
Q03574, ELO4_CAEELQ54CJ4, ELOA_DICDIQ9VH58, ELOF_DROME
B4QVX4, ELOF_DROSIQ9UTF7, ELOH1_SCHPOQ7LKX0, ELOH2_SCHPO
Q9BW60, ELOV1_HUMANQ9JLJ5, ELOV1_MOUSEQ9NXB9, ELOV2_HUMAN
Q9JLJ4, ELOV2_MOUSED4A612, ELOV2_RATQ9HB03, ELOV3_HUMAN
O35949, ELOV3_MOUSEQ9GZR5, ELOV4_HUMANQ95K73, ELOV4_MACFA
Q3S8M4, ELOV4_MACMUQ9EQC4, ELOV4_MOUSEQ2KJD9, ELOV5_BOVIN
Q9NYP7, ELOV5_HUMANQ4R516, ELOV5_MACFAQ8BHI7, ELOV5_MOUSE
Q5RFL5, ELOV5_PONABQ920L7, ELOV5_RATA0A0C5PHQ7, ELOV5_TACFU
Q32NI8, ELOV5_XENLAQ5M8U1, ELOV5_XENTRQ5ZJR8, ELOV6_CHICK
Q6PC64, ELOV6_DANREQ9VV87, ELOV6_DROMEQ9H5J4, ELOV6_HUMAN
Q920L5, ELOV6_MOUSEQ920L6, ELOV6_RATA0JNC4, ELOV7_BOVIN
Q9VHX7, ELOV7_DROMEA1L3X0, ELOV7_HUMANQ9D2Y9, ELOV7_MOUSE
D4ADY9, ELOV7_RATQ1HRV8, ELVL1_AEDAEQ570B4, KCS10_ARATH
O48780, KCS11_ARATHQ9SIB2, KCS12_ARATHQ9ZUZ0, KCS13_ARATH
Q9SS39, KCS14_ARATHQ9SUY9, KCS15_ARATHQ9SYZ0, KCS16_ARATH
O65677, KCS17_ARATHQ38860, KCS18_ARATHQ9LZ72, KCS19_ARATH
Q9MAM3, KCS1_ARATHQ9FG87, KCS20_ARATHQ7XEM4, KCS20_ORYSJ
Q9FH27, KCS21_ARATHQ5XEP9, KCS2_ARATHQ9LQP8, KCS3_ARATH
Q9LN49, KCS4_ARATHQ9C6L5, KCS5_ARATHQ9XF43, KCS6_ARATH
Q9C992, KCS7_ARATHQ4V3C9, KCS8_ARATHQ9SIX1, KCS9_ARATH
Q54TC9, SRE1_DICDIQ86JM5, Y2012_DICDIQ555E8, Y4669_DICDI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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