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ENZYME

ENZYME entry: EC 4.2.1.134

PURL: https://purl.expasy.org/enzyme/EC/4.2.1.134
Accepted Name
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Reaction catalysed
a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O
Comment(s)
  • This is the third component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long chain acyl CoAs. cf. EC 1.1.1.330, EC 1.3.1.93 and EC 2.3.1.199.
  • Formerly EC 2.3.1.119 and EC 4.2.1.n2.
Cross-references
BRENDA4.2.1.134
EC2PDB4.2.1.134
ExplorEnz4.2.1.134
KEGG Ligand Database for Enzyme Nomenclature4.2.1.134
IUBMB Enzyme Nomenclature4.2.1.134
MEDLINEFind literature relating to 4.2.1.134
MetaCyc4.2.1.134
Rhea expert-curated reactions4.2.1.134
UniProtKB/Swiss-Prot
Q4W1W1, HACD1_CANLFB0YJ81, HACD1_HUMANQ9QY80, HACD1_MOUSE
Q9N1R5, HACD1_SHEEPQ2KIP8, HACD2_BOVINQ6Y1H2, HACD2_HUMAN
Q9D3B1, HACD2_MOUSEQ5RBK3, HACD2_PONABA7YY55, HACD3_BOVIN
Q5ZM57, HACD3_CHICKQ7SY06, HACD3_DANREQ9P035, HACD3_HUMAN
Q8K2C9, HACD3_MOUSEQ5NVQ2, HACD3_PONABQ0P5C7, HACD4_BOVIN
Q5VWC8, HACD4_HUMANA2AKM2, HACD4_MOUSEQ6GNB5, HACD4_XENLA
Q7XSZ4, HACDA_ORYSJQ5ZEJ0, HACDB_ORYSJQ8VZB2, HACD_ARATH
O17040, HACD_CAEELO14346, HACD_SCHPOP40857, HACD_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-