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ENZYME entry: EC 4.2.1.134

Accepted Name
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase.
Reaction catalysed
a very-long-chain (3R)-3-hydroxyacyl-CoA <=> a very-long-chain (2E)-enoyl-CoA + H2O
Comment(s)
  • This is the third component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long chain acyl CoAs.
  • Cf. EC 2.3.1.199, EC 1.1.1.330 and EC 1.3.1.93.
  • Formerly EC 2.3.1.119 and EC 4.2.1.n2.
Cross-references
BRENDA4.2.1.134
EC2PDB4.2.1.134
ExplorEnz4.2.1.134
PRIAM enzyme-specific profiles4.2.1.134
KEGG Ligand Database for Enzyme Nomenclature4.2.1.134
IUBMB Enzyme Nomenclature4.2.1.134
IntEnz4.2.1.134
MEDLINEFind literature relating to 4.2.1.134
MetaCyc4.2.1.134
Rhea expert-curated reactions4.2.1.134
UniProtKB/Swiss-Prot
Q4W1W1, HACD1_CANLF;  B0YJ81, HACD1_HUMAN;  Q9QY80, HACD1_MOUSE;  
Q9N1R5, HACD1_SHEEP;  Q2KIP8, HACD2_BOVIN;  Q6Y1H2, HACD2_HUMAN;  
Q9D3B1, HACD2_MOUSE;  Q5RBK3, HACD2_PONAB;  A7YY55, HACD3_BOVIN;  
Q5ZM57, HACD3_CHICK;  Q7SY06, HACD3_DANRE;  Q9P035, HACD3_HUMAN;  
Q8K2C9, HACD3_MOUSE;  Q5NVQ2, HACD3_PONAB;  Q0P5C7, HACD4_BOVIN;  
Q5VWC8, HACD4_HUMAN;  A2AKM2, HACD4_MOUSE;  Q6GNB5, HACD4_XENLA;  
Q7XSZ4, HACDA_ORYSJ;  Q5ZEJ0, HACDB_ORYSJ;  Q8VZB2, HACD_ARATH;  
O17040, HACD_CAEEL;  O14346, HACD_SCHPO;  P40857, HACD_YEAST;  

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