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ENZYME entry: EC

Accepted Name
alkyl sulfatase
Alternative Name(s)
2-oxoglutarate-dependent sulfate ester dioxygenase
alpha-ketoglutarate-dependent sulfate ester dioxygenase
type II alkyl sulfatase
Reaction catalysed
2-oxoglutarate + a primary linear alkyl sulfate ester + O2 <=> an aldehyde + CO2 + H(+) + succinate + sulfate
  • Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors.
  • The type II sulfatases oxidize the C-H bond of the carbon next to the sulfate ester, using 2-oxoglutarate and oxygen as substrates.
  • The resulting hemiacetal sulfate ester collapses, liberating inorganic sulfate and an alkyl aldehyde along with carbon dioxide and succinate.
  • The enzymes often desulfate a broad spectrum of linear and branched- chain sulfate esters.
  • The enzyme from Pseudomonas putida acts on a range of medium-chain alkyl sulfate esters, with chain lengths ranging from C4 to C12. cf. sulfatase EC, EC, and EC
PRIAM enzyme-specific profiles1.14.11.77
KEGG Ligand Database for Enzyme Nomenclature1.14.11.77
IUBMB Enzyme Nomenclature1.14.11.77
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.11.77

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