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ENZYME entry: EC

Accepted Name
Alkyl sulfatase.
Alternative Name(s)
2-oxoglutarate-dependent sulfate ester dioxygenase.
Alpha-ketoglutarate-dependent sulfate ester dioxygenase.
Type II alkyl sulfatase.
Reaction catalysed
A primary alkyl sulfate ester + 2-oxoglutarate + O(2) <=> an aldehyde + succinate + CO(2) + sulfate
  • Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors.
  • The type II sulfatases oxidize the C-H bond of the carbon next to the sulfate ester, using 2-oxoglutarate and oxygen as substrates.
  • The resulting hemiacetal sulfate ester collapses, liberating inorganic sulfate and an alkyl aldehyde along with carbon dioxide and succinate.
  • The enzymes often desulfate a broad spectrum of linear and branched- chain sulfate esters.
  • The enzyme from Pseudomonas putida acts on a range of medium-chain alkyl sulfate esters, with chain lengths ranging from C(4) to C(12).
  • cf. EC, EC, EC, and linear primary- alkylsulfatase.
PRIAM enzyme-specific profiles1.14.11.77
KEGG Ligand Database for Enzyme Nomenclature1.14.11.77
IUBMB Enzyme Nomenclature1.14.11.77
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.11.77

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