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ENZYME

ENZYME entry: EC 1.14.11.77

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.77
Accepted Name
alkyl sulfatase
Alternative Name(s)
2-oxoglutarate-dependent sulfate ester dioxygenase
alpha-ketoglutarate-dependent sulfate ester dioxygenase
type II alkyl sulfatase
Reaction catalysed
a primary linear alkyl sulfate ester + 2-oxoglutarate + O2 = an aldehyde + sulfate + succinate + CO2 + H(+)
Comment(s)
  • Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors.
  • The type II sulfatases oxidize the C-H bond of the carbon next to the sulfate ester, using 2-oxoglutarate and oxygen as substrates.
  • The resulting hemiacetal sulfate ester collapses, liberating inorganic sulfate and an alkyl aldehyde along with carbon dioxide and succinate.
  • The enzymes often desulfate a broad spectrum of linear and branched- chain sulfate esters.
  • The enzyme from Pseudomonas putida acts on a range of medium-chain alkyl sulfate esters, with chain lengths ranging from C4 to C12. cf. sulfatase EC 3.1.6.1, EC 3.1.6.21, and EC 3.1.6.22.
Cross-references
BRENDA1.14.11.77
EC2PDB1.14.11.77
ExplorEnz1.14.11.77
KEGG Ligand Database for Enzyme Nomenclature1.14.11.77
IUBMB Enzyme Nomenclature1.14.11.77
MEDLINEFind literature relating to 1.14.11.77
MetaCyc1.14.11.77
Rhea expert-curated reactions1.14.11.77
UniProtKB/Swiss-Prot
P65076, ATSK_MYCBOP9WKZ0, ATSK_MYCTOP9WKZ1, ATSK_MYCTU
Q9WWU5, ATSK_PSEPU

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