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ENZYME

ENZYME entry: EC 1.14.14.18

Accepted Name
heme oxygenase (biliverdin-producing)
Alternative Name(s)
heme oxidase
heme oxygenase
heme oxygenase (decyclizing)
Reaction catalysed
heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • This mammalian enzyme participates in the degradation of heme.
  • The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules.
  • The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO.
  • The enzyme requires NAD(P)H and EC 1.6.2.4. cf. EC 1.14.15.20.
  • Formerly EC 1.14.99.3.
Cross-references
BRENDA1.14.14.18
EC2PDB1.14.14.18
ExplorEnz1.14.14.18
PRIAM enzyme-specific profiles1.14.14.18
KEGG Ligand Database for Enzyme Nomenclature1.14.14.18
IUBMB Enzyme Nomenclature1.14.14.18
IntEnz1.14.14.18
MEDLINEFind literature relating to 1.14.14.18
MetaCyc1.14.14.18
Rhea expert-curated reactions1.14.14.18
UniProtKB/Swiss-Prot
C3PAD1, HDOX_BACAAC3L7Z8, HDOX_BACACA0RJE3, HDOX_BACAH
Q81L50, HDOX_BACANB7JR48, HDOX_BACC0Q72ZK2, HDOX_BACC1
B7IJU1, HDOX_BACC2C1ETY1, HDOX_BACC3B7HF56, HDOX_BACC4
B7HRI4, HDOX_BACC7B9J044, HDOX_BACCQQ812Q3, HDOX_BACCR
Q633Q1, HDOX_BACCZQ6HCY5, HDOX_BACHKA9VJK2, HDOX_BACMK
Q9K7R6, HDOX_HALH5Q7AP29, HDOX_LISINC1KZZ5, HDOX_LISMC
Q723G7, HDOX_LISMFB8DCJ3, HDOX_LISMHQ92EH3, HDOX_LISMO
A0AFT8, HDOX_LISW6Q5WCF2, HDOX_SHOC1O31534, HMOA_BACSU
P38049, HMOB_BACSUO48782, HMOX1_ARATHQ5E9F2, HMOX1_BOVIN
P14791, HMOX1_CHICKP09601, HMOX1_HUMANP14901, HMOX1_MOUSE
Q69XJ4, HMOX1_ORYSJP32394, HMOX1_PIGQ5R7E3, HMOX1_PONAB
P06762, HMOX1_RATP30519, HMOX2_HUMANQ2PG53, HMOX2_MACFA
O70252, HMOX2_MOUSEP43242, HMOX2_RABITP23711, HMOX2_RAT
Q9C9L4, HMOX3_ARATHO70453, HMOX3_RATQ9LQC0, HMOX4_ARATH
O73688, HMOX_TAKRUP71119, HMUO_CORDII3SL57, HO1_LOTJA
Q8YVS7, HO1_NOSS1P72849, HO1_SYNY3P74133, HO2_SYNY3
O78497, HO_GUITHQ1XDL5, HO_NEOYEP51271, HO_PORPU
O19998, HO_RHOVLA0A0H2XEA6, HO_XANC8

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