ENZYME entry: EC 1.14.14.18

Accepted Name

heme oxygenase (biliverdin-producing)

Alternative Name(s)

heme oxidase

heme oxygenase

heme oxygenase (decyclizing)

Reaction catalysed

heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]

Comment(s)

This mammalian enzyme participates in the degradation of heme.
The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules.
The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO.
The enzyme requires NAD(P)H and EC 1.6.2.4. cf. EC 1.14.15.20.
Formerly EC 1.14.99.3.

Cross-references

BRENDA

1.14.14.18

EC2PDB

1.14.14.18

ExplorEnz

1.14.14.18

PRIAM enzyme-specific profiles

1.14.14.18

KEGG Ligand Database for Enzyme Nomenclature

1.14.14.18

IUBMB Enzyme Nomenclature

1.14.14.18

IntEnz

1.14.14.18

MEDLINE

Find literature relating to 1.14.14.18

MetaCyc

1.14.14.18

Rhea expert-curated reactions

1.14.14.18

UniProtKB/Swiss-Prot

C3PAD1, HDOX_BACAA	C3L7Z8, HDOX_BACAC	A0RJE3, HDOX_BACAH
Q81L50, HDOX_BACAN	B7JR48, HDOX_BACC0	Q72ZK2, HDOX_BACC1
B7IJU1, HDOX_BACC2	C1ETY1, HDOX_BACC3	B7HF56, HDOX_BACC4
B7HRI4, HDOX_BACC7	B9J044, HDOX_BACCQ	Q812Q3, HDOX_BACCR
Q633Q1, HDOX_BACCZ	Q6HCY5, HDOX_BACHK	A9VJK2, HDOX_BACMK
Q9K7R6, HDOX_HALH5	Q7AP29, HDOX_LISIN	C1KZZ5, HDOX_LISMC
Q723G7, HDOX_LISMF	B8DCJ3, HDOX_LISMH	Q92EH3, HDOX_LISMO
A0AFT8, HDOX_LISW6	Q5WCF2, HDOX_SHOC1	O31534, HMOA_BACSU
P38049, HMOB_BACSU	O48782, HMOX1_ARATH	Q5E9F2, HMOX1_BOVIN
P14791, HMOX1_CHICK	P09601, HMOX1_HUMAN	P14901, HMOX1_MOUSE
Q69XJ4, HMOX1_ORYSJ	P32394, HMOX1_PIG	Q5R7E3, HMOX1_PONAB
P06762, HMOX1_RAT	P30519, HMOX2_HUMAN	Q2PG53, HMOX2_MACFA
O70252, HMOX2_MOUSE	P43242, HMOX2_RABIT	P23711, HMOX2_RAT
Q9C9L4, HMOX3_ARATH	O70453, HMOX3_RAT	Q9LQC0, HMOX4_ARATH
O73688, HMOX_TAKRU	P71119, HMUO_CORDI	I3SL57, HO1_LOTJA
Q8YVS7, HO1_NOSS1	P72849, HO1_SYNY3	P74133, HO2_SYNY3
O78497, HO_GUITH	Q1XDL5, HO_NEOYE	P51271, HO_PORPU
O19998, HO_RHOVL	A0A0H2XEA6, HO_XANC8

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