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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.14.18

Accepted Name
Heme oxygenase (biliverdin-producing).
Alternative Name(s)
Heme oxidase.
Heme oxygenase.
Heme oxygenase (decyclizing).
Reaction catalysed
Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) <=> biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O
Comment(s)
  • This mammalian enzyme participates in the degradation of heme.
  • The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules.
  • The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO.
  • The enzyme requires NAD(P)H and EC 1.6.2.4.
  • Cf. EC 1.14.15.20.
  • Formerly EC 1.14.99.3.
Cross-references
PROSITEPDOC00512
BRENDA1.14.14.18
EC2PDB1.14.14.18
ExplorEnz1.14.14.18
PRIAM enzyme-specific profiles1.14.14.18
KEGG Ligand Database for Enzyme Nomenclature1.14.14.18
IUBMB Enzyme Nomenclature1.14.14.18
IntEnz1.14.14.18
MEDLINEFind literature relating to 1.14.14.18
MetaCyc1.14.14.18
UniProtKB/Swiss-Prot
C3PAD1, HDOX_BACAA;  C3L7Z8, HDOX_BACAC;  A0RJE3, HDOX_BACAH;  
Q81L50, HDOX_BACAN;  B7JR48, HDOX_BACC0;  Q72ZK2, HDOX_BACC1;  
B7IJU1, HDOX_BACC2;  C1ETY1, HDOX_BACC3;  B7HF56, HDOX_BACC4;  
B7HRI4, HDOX_BACC7;  B9J044, HDOX_BACCQ;  Q812Q3, HDOX_BACCR;  
Q633Q1, HDOX_BACCZ;  Q9K7R6, HDOX_BACHD;  Q6HCY5, HDOX_BACHK;  
Q5WCF2, HDOX_BACSK;  A9VJK2, HDOX_BACWK;  Q7AP29, HDOX_LISIN;  
C1KZZ5, HDOX_LISMC;  Q723G7, HDOX_LISMF;  B8DCJ3, HDOX_LISMH;  
Q92EH3, HDOX_LISMO;  A0AFT8, HDOX_LISW6;  O31534, HMOA_BACSU;  
P38049, HMOB_BACSU;  O48782, HMOX1_ARATH;  Q5E9F2, HMOX1_BOVIN;  
P14791, HMOX1_CHICK;  P09601, HMOX1_HUMAN;  P14901, HMOX1_MOUSE;  
Q69XJ4, HMOX1_ORYSJ;  P32394, HMOX1_PIG;  Q5R7E3, HMOX1_PONAB;  
P06762, HMOX1_RAT;  P30519, HMOX2_HUMAN;  Q2PG53, HMOX2_MACFA;  
O70252, HMOX2_MOUSE;  P43242, HMOX2_RABIT;  P23711, HMOX2_RAT;  
Q9C9L4, HMOX3_ARATH;  O70453, HMOX3_RAT;  Q9LQC0, HMOX4_ARATH;  
O73688, HMOX_TAKRU;  P71119, HMUO_CORDI;  Q8YVS7, HO1_NOSS1;  
P72849, HO1_SYNY3;  P74133, HO2_SYNY3;  O78497, HO_GUITH;  
P51271, HO_PORPU;  Q1XDL5, HO_PYRYE;  O19998, HO_RHOVL;  
A0A0H2XEA6, HO_XANC8;  P9WKH2, MHUD_MYCTO;  P9WKH3, MHUD_MYCTU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
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