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ENZYME

ENZYME entry: EC 1.14.14.29

Accepted Name
25/26-hydroxycholesterol 7alpha-hydroxylase
Alternative Name(s)
25-hydroxycholesterol 7alpha-hydroxylase
25-hydroxycholesterol 7alpha-monooxygenase
27-hydroxycholesterol 7alpha-hydroxylase
27-hydroxycholesterol 7-monooxygenase
Reaction catalysed
  • 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
  • (25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] = (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • Unlike EC 1.14.14.26, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25- epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.60 and EC 1.14.13.100.
Cross-references
BRENDA1.14.14.29
EC2PDB1.14.14.29
ExplorEnz1.14.14.29
PRIAM enzyme-specific profiles1.14.14.29
KEGG Ligand Database for Enzyme Nomenclature1.14.14.29
IUBMB Enzyme Nomenclature1.14.14.29
IntEnz1.14.14.29
MEDLINEFind literature relating to 1.14.14.29
MetaCyc1.14.14.29
Rhea expert-curated reactions1.14.14.29
UniProtKB/Swiss-Prot
O75881, CP7B1_HUMANQ60991, CP7B1_MOUSEQ63688, CP7B1_RAT

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