ENZYME entry: EC 1.14.14.29

Accepted Name
25/26-hydroxycholesterol 7-alpha-hydroxylase.
Alternative Name(s)
25-hydroxycholesterol 7-alpha-hydroxylase.
25-hydroxycholesterol 7-alpha-monooxygenase.
27-hydroxycholesterol 7-alpha-hydroxylase.
27-hydroxycholesterol 7-monooxygenase.
Reaction catalysed
  • Cholest-5-ene-3-beta,25-diol + [reduced NADPH--hemoprotein reductase] + O(2) <=> cholest-5-ene-3-beta,7-alpha,25-triol + [oxidized NADPH--hemoprotein reductase] + H(2)O
  • (25R)-cholest-5-ene-3-beta,26-diol + [reduced NADPH--hemoprotein reductase] + O(2) <=> (25R)-cholest-5-ene-3-beta,7-alpha,26-triol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Unlike EC 1.14.14.26, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25- epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.60 and EC 1.14.13.100.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.29
EC2PDB1.14.14.29
ExplorEnz1.14.14.29
PRIAM enzyme-specific profiles1.14.14.29
KEGG Ligand Database for Enzyme Nomenclature1.14.14.29
IUBMB Enzyme Nomenclature1.14.14.29
IntEnz1.14.14.29
MEDLINEFind literature relating to 1.14.14.29
MetaCyc1.14.14.29
UniProtKB/Swiss-Prot
O75881, CP7B1_HUMAN;  Q60991, CP7B1_MOUSE;  Q63688, CP7B1_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-