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ENZYME

ENZYME entry: EC 1.14.18.10

PURL: https://purl.expasy.org/enzyme/EC/1.14.18.10
Accepted Name
plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase
Reaction catalysed
24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H(+) = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
Comment(s)
  • This plant enzyme catalyzes a step in the biosynthesis of sterols.
  • It acts on the 4alpha-methyl group of the 4,4-dimethylated intermediate 24-methylenecycloartanol and catalyzes three successive oxidations, turning it into a carboxyl group.
  • The carboxylate is subsequently removed by EC 1.1.1.418, which also catalyzes the epimerization of the remaining 4beta-methyl into the 4alpha position.
  • Unlike the fungal/animal enzyme EC 1.14.18.9, this enzyme is not able to remove the methyl group from C-4-monomethylated substrates.
  • That activity is performed in plants by a second enzyme, EC 1.14.18.11.
Cross-references
BRENDA1.14.18.10
EC2PDB1.14.18.10
ExplorEnz1.14.18.10
KEGG Ligand Database for Enzyme Nomenclature1.14.18.10
IUBMB Enzyme Nomenclature1.14.18.10
MEDLINEFind literature relating to 1.14.18.10
MetaCyc1.14.18.10
Rhea expert-curated reactions1.14.18.10
UniProtKB/Swiss-Prot
Q8L7W5, SMO11_ARATHQ1EC69, SMO12_ARATH

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