ENZYME entry: EC 22.214.171.124
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|plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase.
|24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O|
- This plant enzyme catalyzes a step in the biosynthesis of sterols.
- It acts on the 4alpha-methyl group of the 4,4-dimethylated
intermediate 24-methylenecycloartanol and catalyzes three successive
oxidations, turning it into a carboxyl group.
- The carboxylate is subsequently removed by EC 126.96.36.1998, which also
catalyzes the epimerization of the remaining 4beta-methyl into the
- Unlike the fungal/animal enzyme EC 188.8.131.52, this enzyme is not able
to remove the methyl group from C-4-monomethylated substrates.
- That activity is performed in plants by a second enzyme,
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
|Rhea expert-curated reactions||126.96.36.199|
entries corresponding to 1.14.18.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-