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ENZYME

ENZYME entry: EC 1.14.18.11

PURL: https://purl.expasy.org/enzyme/EC/1.14.18.11
Accepted Name
plant 4alpha-monomethylsterol monooxygenase
Reaction catalysed
24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H(+) = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
Comment(s)
  • This plant enzyme catalyzes a step in the biosynthesis of sterols.
  • It acts on the methyl group of the 4alpha-methylated intermediates 24-ethylidenelophenol and 24-methylidenelophenol and catalyzes three successive oxidations, turning it into a carboxyl group.
  • The carboxylate is subsequently removed by EC 1.1.1.418.
  • Unlike the fungal/animal enzyme EC 1.14.18.9, this enzyme is not able to act on 4,4-dimethylated substrates.
  • That activity, which occurs earlier in the pathway, is performed in plants by a second enzyme, EC 1.14.18.10.
Cross-references
BRENDA1.14.18.11
EC2PDB1.14.18.11
ExplorEnz1.14.18.11
KEGG Ligand Database for Enzyme Nomenclature1.14.18.11
IUBMB Enzyme Nomenclature1.14.18.11
MEDLINEFind literature relating to 1.14.18.11
MetaCyc1.14.18.11
Rhea expert-curated reactions1.14.18.11
UniProtKB/Swiss-Prot
F4JLZ6, SMO13_ARATHQ9ZW22, SMO21_ARATHQ8VWZ8, SMO22_ARATH

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