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ENZYME entry: EC 1.14.18.11

Accepted Name
Plant 4-alpha-monomethylsterol monooxygenase.
Reaction catalysed
24-methylidenelophenol + 6 ferrocytochrome b5 + 3 O(2) + 6 H(+) <=> 4-alpha-carboxy-ergosta-7,24(24(1))-dien-3-beta-ol + 6 ferricytochrome b5 + 4 H(2)O
Comment(s)
  • This plant enzyme catalyzes a step in the biosynthesis of sterols.
  • It acts on the methyl group of the 4-alpha-methylated intermediates 24-ethylidenelophenol and 24-methylidenelophenol and catalyzes three successive oxidations, turning it into a carboxyl group.
  • The carboxylate is subsequently removed by EC 1.1.1.418.
  • Unlike the fungal/animal enzyme EC 1.14.18.9, this enzyme is not able to act on 4,4-dimethylated substrates.
  • That activity, which occurs earlier in the pathway, is performed in plants by a second enzyme, EC 1.14.18.10.
Cross-references
BRENDA1.14.18.11
EC2PDB1.14.18.11
ExplorEnz1.14.18.11
PRIAM enzyme-specific profiles1.14.18.11
KEGG Ligand Database for Enzyme Nomenclature1.14.18.11
IUBMB Enzyme Nomenclature1.14.18.11
IntEnz1.14.18.11
MEDLINEFind literature relating to 1.14.18.11
MetaCyc1.14.18.11
Rhea expert-curated reactions1.14.18.11

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.18.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-