ENZYME entry: EC 1.14.19.58
| Accepted Name |
|---|
| Tryptophan 5-halogenase.
|
| Reaction catalysed |
|---|
| L-tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 5-chloro-L-tryptophan + FAD + 2 H(2)O |
| Comment(s) |
|---|
- A flavin-dependent halogenase.
- The enzyme from the bacterium Streptomyces rugosporus catalyzes
halogenation of the C-5 position of tryptophan during the
biosynthesis of the antibiotic compound pyrroindomycin B.
- It utilizes molecular oxygen to oxidize the FADH(2) cofactor, giving
C4a-hydroperoxyflavin, which then reacts with chloride to produce a
hypochlorite ion.
- The latter reacts with an active site lysine to generate a
chloramine, which chlorinates the substrate.
- cf. EC 1.14.19.59 and EC 1.14.19.9.
|
| Cross-references |
|---|
| BRENDA | 1.14.19.58 |
| EC2PDB | 1.14.19.58 |
| ExplorEnz | 1.14.19.58 |
| PRIAM enzyme-specific profiles | 1.14.19.58 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.58 |
| IUBMB Enzyme Nomenclature | 1.14.19.58 |
| IntEnz | 1.14.19.58 |
| MEDLINE | Find literature relating to 1.14.19.58 |
| MetaCyc | 1.14.19.58 |
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-