ENZYME entry: EC 1.14.19.58
| Accepted Name |
|---|
| tryptophan 5-halogenase.
|
| Reaction catalysed |
|---|
| chloride + FADH2 + L-tryptophan + O2 <=> 5-chloro-L-tryptophan + FAD + 2 H2O |
| Comment(s) |
|---|
- A flavin-dependent halogenase.
- The enzyme from the bacterium Streptomyces rugosporus catalyzes
halogenation of the C-5 position of tryptophan during the
biosynthesis of the antibiotic compound pyrroindomycin B.
- It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving
C4a-hydroperoxyflavin, which then reacts with chloride to produce a
hypochlorite ion.
- The latter reacts with an active site lysine to generate a
chloramine, which chlorinates the substrate.
- cf. EC 1.14.19.59 and EC 1.14.19.9.
|
| Cross-references |
|---|
| BRENDA | 1.14.19.58 |
| EC2PDB | 1.14.19.58 |
| ExplorEnz | 1.14.19.58 |
| PRIAM enzyme-specific profiles | 1.14.19.58 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.58 |
| IUBMB Enzyme Nomenclature | 1.14.19.58 |
| IntEnz | 1.14.19.58 |
| MEDLINE | Find literature relating to 1.14.19.58 |
| MetaCyc | 1.14.19.58 |
| Rhea expert-curated reactions | 1.14.19.58 |
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