ENZYME entry: EC 1.14.19.59
Accepted Name |
Tryptophan 6-halogenase.
|
Reaction catalysed |
- L-tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 6-chloro-L-tryptophan + FAD + 2 H(2)O
- D-tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 6-chloro-D-tryptophan + FAD + 2 H(2)O
|
Comment(s) |
- The enzyme is a flavin-dependent halogenase that has been described
from several bacterial species.
- It utilizes molecular oxygen to oxidize the FADH(2) cofactor, giving
C4a-hydroperoxyflavin, which then reacts with chloride to produce a
hypochlorite ion.
- The latter reacts with an active site lysine to generate a
chloramine, which chlorinates the substrate.
- Cf. EC 1.14.19.58 and EC 1.14.19.9.
|
Cross-references |
BRENDA | 1.14.19.59 |
EC2PDB | 1.14.19.59 |
ExplorEnz | 1.14.19.59 |
PRIAM enzyme-specific profiles | 1.14.19.59 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.59 |
IUBMB Enzyme Nomenclature | 1.14.19.59 |
IntEnz | 1.14.19.59 |
MEDLINE | Find literature relating to 1.14.19.59 |
MetaCyc | 1.14.19.59 |
Rhea expert-curated reactions | 1.14.19.59 |
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