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ENZYME

ENZYME entry: EC 1.14.19.59

Accepted Name
tryptophan 6-halogenase
Reaction catalysed
  • chloride + FADH2 + L-tryptophan + O2 = 6-chloro-L-tryptophan + FAD + 2 H2O
  • chloride + D-tryptophan + FADH2 + O2 = 6-chloro-D-tryptophan + FAD + 2 H2O
Comment(s)
  • The enzyme is a flavin-dependent halogenase that has been described from several bacterial species.
  • It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion.
  • The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. Cf. EC 1.14.19.9 and EC 1.14.19.58.
Cross-references
BRENDA1.14.19.59
EC2PDB1.14.19.59
ExplorEnz1.14.19.59
PRIAM enzyme-specific profiles1.14.19.59
KEGG Ligand Database for Enzyme Nomenclature1.14.19.59
IUBMB Enzyme Nomenclature1.14.19.59
IntEnz1.14.19.59
MEDLINEFind literature relating to 1.14.19.59
MetaCyc1.14.19.59
Rhea expert-curated reactions1.14.19.59
UniProtKB/Swiss-Prot
A1E280, TRP6H_STRAOE9P162, TRP6H_STRT5

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