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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Tryptophan 6-halogenase.
Reaction catalysed
  • L-tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 6-chloro-L-tryptophan + FAD + 2 H(2)O
  • D-tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 6-chloro-D-tryptophan + FAD + 2 H(2)O
  • The enzyme is a flavin-dependent halogenase that has been described from several bacterial species.
  • It utilizes molecular oxygen to oxidize the FADH(2) cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion.
  • The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate.
  • Cf. EC and EC
PRIAM enzyme-specific profiles1.14.19.59
KEGG Ligand Database for Enzyme Nomenclature1.14.19.59
IUBMB Enzyme Nomenclature1.14.19.59
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