ENZYME entry: EC 1.14.19.59
| Accepted Name |
|---|
| Tryptophan 6-halogenase.
|
| Reaction catalysed |
|---|
- L-tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 6-chloro-L-tryptophan + FAD + 2 H(2)O
- D-tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 6-chloro-D-tryptophan + FAD + 2 H(2)O
|
| Comment(s) |
|---|
- The enzyme is a flavin-dependent halogenase that has been described
from several bacterial species.
- It utilizes molecular oxygen to oxidize the FADH(2) cofactor, giving
C4a-hydroperoxyflavin, which then reacts with chloride to produce a
hypochlorite ion.
- The latter reacts with an active site lysine to generate a
chloramine, which chlorinates the substrate.
- Cf. EC 1.14.19.58 and EC 1.14.19.9.
|
| Cross-references |
|---|
| BRENDA | 1.14.19.59 |
| EC2PDB | 1.14.19.59 |
| ExplorEnz | 1.14.19.59 |
| PRIAM enzyme-specific profiles | 1.14.19.59 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.59 |
| IUBMB Enzyme Nomenclature | 1.14.19.59 |
| IntEnz | 1.14.19.59 |
| MEDLINE | Find literature relating to 1.14.19.59 |
| MetaCyc | 1.14.19.59 |
| Rhea expert-curated reactions | 1.14.19.59 |
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