A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.17.1.4
Accepted Name |
Xanthine dehydrogenase.
|
Alternative Name(s) |
NAD-xanthine dehydrogenase. |
Xanthine oxidoreductase. |
Xanthine-NAD oxidoreductase. |
Xanthine/NAD(+) oxidoreductase. |
Reaction catalysed |
Xanthine + NAD(+) + H(2)O <=> urate + NADH |
Cofactor(s) |
FAD; Iron-sulfur; Mo cation.
|
Comment(s) |
- Acts on a variety of purines and aldehydes, including hypoxanthine.
- The mammalian enzyme can also convert all-trans retinol to all-trans-
retinoate, while the substrate is bound to a retinoid-binding
protein.
- The enzyme from eukaryotes contains [2Fe-2S], FAD and a molybdenum
center.
- The mammallian enzyme predominantly exists as the NAD-dependent
dehydrogenase (EC 1.17.1.4).
- During purification the enzyme is largely converted to an O(2)-
dependent form, EC 1.17.3.2.
- The conversion can be triggered by several mechanisms, including the
oxidation of cysteine thiols to form disulfide bonds (which can be
catalyzed by EC 1.8.4.7 in the presence of glutathione disulfide) or
limited proteolysis, which results in irreversible conversion.
- The conversion can also occur in vivo.
- Formerly EC 1.2.1.37 and EC 1.1.1.204.
|
Cross-references |
PROSITE | PDOC00484 |
BRENDA | 1.17.1.4 |
EC2PDB | 1.17.1.4 |
ExplorEnz | 1.17.1.4 |
PRIAM enzyme-specific profiles | 1.17.1.4 |
KEGG Ligand Database for Enzyme Nomenclature | 1.17.1.4 |
IUBMB Enzyme Nomenclature | 1.17.1.4 |
IntEnz | 1.17.1.4 |
MEDLINE | Find literature relating to 1.17.1.4 |
MetaCyc | 1.17.1.4 |
UniProtKB/Swiss-Prot |
Q8GUQ8, XDH1_ARATH; | F4JLI5, XDH2_ARATH; | O32147, XDHA_BACSU; |
Q8X6C7, XDHA_ECO57; | Q46799, XDHA_ECOLI; | Q8X6C5, XDHB_ECO57; |
Q46800, XDHB_ECOLI; | O32145, XDHC_BACSU; | O32144, XDHD_BACSU; |
O32143, XDHE_BACSU; | R4ZGN4, XDH_BLAAD; | P80457, XDH_BOVIN; |
P08793, XDH_CALVI; | P47990, XDH_CHICK; | Q54FB7, XDH_DICDI; |
P10351, XDH_DROME; | P22811, XDH_DROPS; | P91711, XDH_DROSU; |
Q12553, XDH_EMENI; | Q9MYW6, XDH_FELCA; | P47989, XDH_HUMAN; |
Q00519, XDH_MOUSE; | Q6AUV1, XDH_ORYSJ; | P22985, XDH_RAT; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.17.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-